mediator complex Gene Set

Dataset COMPARTMENTS Curated Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. (Gene Ontology, GO_0016592)
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Genes

35 proteins localized to the mediator complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
MED30 mediator complex subunit 30 0.663342
MED16 mediator complex subunit 16 0.663342
MED17 mediator complex subunit 17 0.663342
MED18 mediator complex subunit 18 0.663342
THRAP3 thyroid hormone receptor associated protein 3 0.663342
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta 0.663342
MED29 mediator complex subunit 29 0.663342
MED21 mediator complex subunit 21 0.663342
MED20 mediator complex subunit 20 0.663342
MED22 mediator complex subunit 22 0.663342
MED24 mediator complex subunit 24 0.663342
RBM14 RNA binding motif protein 14 0.663342
CDK8 cyclin-dependent kinase 8 0.663342
MED14 mediator complex subunit 14 0.663342
MED13 mediator complex subunit 13 0.663342
MED12 mediator complex subunit 12 0.663342
MED1 mediator complex subunit 1 0.663342
MED26 mediator complex subunit 26 0.663342
MED4 mediator complex subunit 4 0.663342
MED8 mediator complex subunit 8 0.663342
RBM4 RNA binding motif protein 4 0.663342
MED11 mediator complex subunit 11 0.663342
MED6 mediator complex subunit 6 0.237908
MED19 mediator complex subunit 19 0.03318
MED31 mediator complex subunit 31 0.03318
MED13L mediator complex subunit 13-like 0.03318
MED23 mediator complex subunit 23 0.03318
MED27 mediator complex subunit 27 0.03318
CCNC cyclin C 0.03318
MED12L mediator complex subunit 12-like 0.03318
MED15 mediator complex subunit 15 0.03318
MED10 mediator complex subunit 10 0.03318
MED7 mediator complex subunit 7 0.03318
MED9 mediator complex subunit 9 0.03318
MED28 mediator complex subunit 28 0.03318