meclozine-5244 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the meclozine-5244 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AMACR alpha-methylacyl-CoA racemase
ANGPT4 angiopoietin 4
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATM ATM serine/threonine kinase
BCAM basal cell adhesion molecule (Lutheran blood group)
BGN biglycan
C10ORF95 chromosome 10 open reading frame 95
C22ORF46 chromosome 22 open reading frame 46
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CD101 CD101 molecule
CD6 CD6 molecule
CDHR2 cadherin-related family member 2
CFHR2 complement factor H-related 2
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLEC4M C-type lectin domain family 4, member M
CLGN calmegin
COL21A1 collagen, type XXI, alpha 1
CSNK1G1 casein kinase 1, gamma 1
CTNS cystinosin, lysosomal cystine transporter
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34
DIAPH2-AS1 DIAPH2 antisense RNA 1
DOK5 docking protein 5
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EPN1 epsin 1
FBXO41 F-box protein 41
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
GJA4 gap junction protein, alpha 4, 37kDa
GM2A GM2 ganglioside activator
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GPR137 G protein-coupled receptor 137
GRIK1 glutamate receptor, ionotropic, kainate 1
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4
IHH indian hedgehog
INHBE inhibin, beta E
IRAK3 interleukin-1 receptor-associated kinase 3
IRS2 insulin receptor substrate 2
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2
KLHL3 kelch-like family member 3
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT16 keratin 16, type I
LARP7 La ribonucleoprotein domain family, member 7
LINC00341 long intergenic non-protein coding RNA 341
LOXL3 lysyl oxidase-like 3
LPL lipoprotein lipase
MAP2K5 mitogen-activated protein kinase kinase 5
MARK2 MAP/microtubule affinity-regulating kinase 2
MOBP myelin-associated oligodendrocyte basic protein
MUC3B mucin 3B, cell surface associated
MYOZ1 myozenin 1
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NPY neuropeptide Y
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUPR1 nuclear protein, transcriptional regulator, 1
PCDH11Y protocadherin 11 Y-linked
PCDH9 protocadherin 9
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLCD1 phospholipase C, delta 1
PLK3 polo-like kinase 3
PNMAL1 paraneoplastic Ma antigen family-like 1
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPP1R2P9 protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 9
PRB1 proline-rich protein BstNI subfamily 1
PRPH2 peripherin 2 (retinal degeneration, slow)
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic)
RPL35A ribosomal protein L35a
RUNDC3B RUN domain containing 3B
RUNX1 runt-related transcription factor 1
SDC3 syndecan 3
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STAT2 signal transducer and activator of transcription 2, 113kDa
STS steroid sulfatase (microsomal), isozyme S
TBC1D22A TBC1 domain family, member 22A
TBCD tubulin folding cofactor D
TM4SF20 transmembrane 4 L six family member 20
TMCC2 transmembrane and coiled-coil domain family 2
TREX1 three prime repair exonuclease 1
TRIM38 tripartite motif containing 38
TRPC4 transient receptor potential cation channel, subfamily C, member 4
TSC22D3 TSC22 domain family, member 3
UBE2H ubiquitin-conjugating enzyme E2H
UNC119 unc-119 homolog (C. elegans)
VEGFA vascular endothelial growth factor A
ZSCAN18 zinc finger and SCAN domain containing 18
ZXDB zinc finger, X-linked, duplicated B

decreased expression

Symbol Name
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ADCY7 adenylate cyclase 7
ADGRE5 adhesion G protein-coupled receptor E5
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ARMC6 armadillo repeat containing 6
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BCL9 B-cell CLL/lymphoma 9
C22ORF29 chromosome 22 open reading frame 29
C5ORF45 chromosome 5 open reading frame 45
CAMK4 calcium/calmodulin-dependent protein kinase IV
CAPN15 calpain 15
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBX8 chromobox homolog 8
CEMIP cell migration inducing protein, hyaluronan binding
CEP85 centrosomal protein 85kDa
CHRM3 cholinergic receptor, muscarinic 3
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DNAH17 dynein, axonemal, heavy chain 17
DVL1 dishevelled segment polarity protein 1
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EFNA3 ephrin-A3
ERMAP erythroblast membrane-associated protein (Scianna blood group)
FAM155B family with sequence similarity 155, member B
FBXL6 F-box and leucine-rich repeat protein 6
FBXO31 F-box protein 31
FIG4 FIG4 phosphoinositide 5-phosphatase
FOSL1 FOS-like antigen 1
FRMD1 FERM domain containing 1
FURIN furin (paired basic amino acid cleaving enzyme)
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GNL1 guanine nucleotide binding protein-like 1
GPX2 glutathione peroxidase 2
GRB7 growth factor receptor-bound protein 7
HDAC11 histone deacetylase 11
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HOXC10 homeobox C10
HOXC8 homeobox C8
HPS6 Hermansky-Pudlak syndrome 6
IFI27 interferon, alpha-inducible protein 27
IL4R interleukin 4 receptor
INPP1 inositol polyphosphate-1-phosphatase
IRF2BP1 interferon regulatory factor 2 binding protein 1
IRF9 interferon regulatory factor 9
KIAA0319L KIAA0319-like
KLC2 kinesin light chain 2
KREMEN2 kringle containing transmembrane protein 2
KRI1 KRI1 homolog (S. cerevisiae)
LINC00597 long intergenic non-protein coding RNA 597
LMNB1 lamin B1
LY6G6C lymphocyte antigen 6 complex, locus G6C
MEFV Mediterranean fever
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MTA2 metastasis associated 1 family, member 2
MUC3A mucin 3A, cell surface associated
MVP major vault protein
MYO1E myosin IE
NCALD neurocalcin delta
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
NPIPB3 nuclear pore complex interacting protein family, member B3
NXPH4 neurexophilin 4
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)
PGBD5 piggyBac transposable element derived 5
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PIPOX pipecolic acid oxidase
PODXL2 podocalyxin-like 2
POMT2 protein-O-mannosyltransferase 2
PRSS53 protease, serine, 53
PTPN9 protein tyrosine phosphatase, non-receptor type 9
RAB30 RAB30, member RAS oncogene family
RAB3A RAB3A, member RAS oncogene family
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RFPL3 ret finger protein-like 3
S100A7 S100 calcium binding protein A7
SCGB2A2 secretoglobin, family 2A, member 2
SLC12A9 solute carrier family 12, member 9
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
STRA6 stimulated by retinoic acid 6
TMEM104 transmembrane protein 104
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TSPAN5 tetraspanin 5
TUBA3C tubulin, alpha 3c
VASH1 vasohibin 1
VPS9D1 VPS9 domain containing 1
XYLT1 xylosyltransferase I
XYLT2 xylosyltransferase II
YBX2 Y box binding protein 2
ZFHX4 zinc finger homeobox 4
ZMYM3 zinc finger, MYM-type 3
ZNF574 zinc finger protein 574
ZNF747 zinc finger protein 747