mapk cascade Gene Set

Dataset GO Biological Process Annotations
Category structural or functional annotations
Type biological process
Description An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. (Gene Ontology, GO_0000165)
External Link http://amigo.geneontology.org/amigo/term/GO:0000165
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Genes

167 genes participating in the mapk cascade biological process from the curated GO Biological Process Annotations dataset.

Symbol Name
ADORA2B adenosine A2b receptor
ADRA2B adrenoceptor alpha 2B
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
APOA1 apolipoprotein A-I
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ATF1 activating transcription factor 1
ATF2 activating transcription factor 2
AVP arginine vasopressin
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRAP BRCA1 associated protein
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CAV1 caveolin 1, caveolae protein, 22kDa
CCL11 chemokine (C-C motif) ligand 11
CCL2 chemokine (C-C motif) ligand 2
CCL3 chemokine (C-C motif) ligand 3
CCL5 chemokine (C-C motif) ligand 5
CCM2 cerebral cavernous malformation 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CDC42EP5 CDC42 effector protein (Rho GTPase binding) 5
CDK1 cyclin-dependent kinase 1
CREB1 cAMP responsive element binding protein 1
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CRYAB crystallin, alpha B
CTSH cathepsin H
DOK4 docking protein 4
DOK5 docking protein 5
DUSP10 dual specificity phosphatase 10
DUSP19 dual specificity phosphatase 19
DUSP28 dual specificity phosphatase 28
DUSP3 dual specificity phosphatase 3
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
DUSP9 dual specificity phosphatase 9
EGF epidermal growth factor
EGFR epidermal growth factor receptor
ELK1 ELK1, member of ETS oncogene family
EPGN epithelial mitogen
FGF10 fibroblast growth factor 10
FGF13 fibroblast growth factor 13
FGF8 fibroblast growth factor 8 (androgen-induced)
FGFR1 fibroblast growth factor receptor 1
FGFR3 fibroblast growth factor receptor 3
FOS FBJ murine osteosarcoma viral oncogene homolog
GPS1 G protein pathway suppressor 1
GPS2 G protein pathway suppressor 2
HRAS Harvey rat sarcoma viral oncogene homolog
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL18 interleukin 18
IL1B interleukin 1, beta
IL31RA interleukin 31 receptor A
INS insulin
IQGAP3 IQ motif containing GTPase activating protein 3
IRAK1 interleukin-1 receptor-associated kinase 1
IRAK2 interleukin-1 receptor-associated kinase 2
IRAK4 interleukin-1 receptor-associated kinase 4
ITGAV integrin, alpha V
ITPKB inositol-trisphosphate 3-kinase B
JUN jun proto-oncogene
KRAS Kirsten rat sarcoma viral oncogene homolog
LRRK2 leucine-rich repeat kinase 2
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAP2K3 mitogen-activated protein kinase kinase 3
MAP2K4 mitogen-activated protein kinase kinase 4
MAP2K5 mitogen-activated protein kinase kinase 5
MAP2K6 mitogen-activated protein kinase kinase 6
MAP2K7 mitogen-activated protein kinase kinase 7
MAP3K10 mitogen-activated protein kinase kinase kinase 10
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MAP3K13 mitogen-activated protein kinase kinase kinase 13
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAP3K15 mitogen-activated protein kinase kinase kinase 15
MAP3K19 mitogen-activated protein kinase kinase kinase 19
MAP3K3 mitogen-activated protein kinase kinase kinase 3
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MAPK1 mitogen-activated protein kinase 1
MAPK10 mitogen-activated protein kinase 10
MAPK11 mitogen-activated protein kinase 11
MAPK12 mitogen-activated protein kinase 12
MAPK13 mitogen-activated protein kinase 13
MAPK14 mitogen-activated protein kinase 14
MAPK15 mitogen-activated protein kinase 15
MAPK3 mitogen-activated protein kinase 3
MAPK4 mitogen-activated protein kinase 4
MAPK6 mitogen-activated protein kinase 6
MAPK7 mitogen-activated protein kinase 7
MAPK8 mitogen-activated protein kinase 8
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2
MAPK9 mitogen-activated protein kinase 9
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MED1 mediator complex subunit 1
MEF2A myocyte enhancer factor 2A
MEF2C myocyte enhancer factor 2C
MEN1 multiple endocrine neoplasia I
MINK1 misshapen-like kinase 1
MOS v-mos Moloney murine sarcoma viral oncogene homolog
MT3 metallothionein 3
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
NEK1 NIMA-related kinase 1
NF1 neurofibromin 1
NLK nemo-like kinase
NOD1 nucleotide-binding oligomerization domain containing 1
NOD2 nucleotide-binding oligomerization domain containing 2
NPHS1 nephrosis 1, congenital, Finnish type (nephrin)
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NRG1 neuregulin 1
NRTN neurturin
OXTR oxytocin receptor
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PLVAP plasmalemma vesicle associated protein
POU4F2 POU class 4 homeobox 2
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L
PPP2R5D protein phosphatase 2, regulatory subunit B', delta
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTK2B protein tyrosine kinase 2 beta
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
RB1CC1 RB1-inducible coiled-coil 1
RBM4 RNA binding motif protein 4
RET ret proto-oncogene
RHBDD3 rhomboid domain containing 3
RIPK2 receptor-interacting serine-threonine kinase 2
ROR2 receptor tyrosine kinase-like orphan receptor 2
RPS27A ribosomal protein S27a
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
SBK2 SH3 domain binding kinase family, member 2
SCG2 secretogranin II
SETX senataxin
SH2D3A SH2 domain containing 3A
SH2D3C SH2 domain containing 3C
SHANK3 SH3 and multiple ankyrin repeat domains 3
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SMAD1 SMAD family member 1
SOX9 SRY (sex determining region Y)-box 9
STRADB STE20-related kinase adaptor beta
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TAB3 TGF-beta activated kinase 1/MAP3K7 binding protein 3
TAOK1 TAO kinase 1
TAOK2 TAO kinase 2
TAOK3 TAO kinase 3
TGFB1 transforming growth factor, beta 1
TNF tumor necrosis factor
TNFRSF19 tumor necrosis factor receptor superfamily, member 19
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRIB1 tribbles pseudokinase 1
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBB ubiquitin B
UBC ubiquitin C
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta