map-kinase-signaling-system Gene Set

Dataset Phosphosite Textmining Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

423 proteins co-occuring with the biological term map-kinase-signaling-system in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

Symbol Name
ACACA acetyl-CoA carboxylase alpha
ACTN4 actinin, alpha 4
ADAM17 ADAM metallopeptidase domain 17
ADD1 adducin 1 (alpha)
ADRB2 adrenoceptor beta 2, surface
AKAP12 A kinase (PRKA) anchor protein 12
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
APP amyloid beta (A4) precursor protein
AQP2 aquaporin 2 (collecting duct)
AR androgen receptor
ARHGAP5 Rho GTPase activating protein 5
ARRB1 arrestin, beta 1
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
ATF1 activating transcription factor 1
ATF2 activating transcription factor 2
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
ATXN1 ataxin 1
AURKA aurora kinase A
BAD BCL2-associated agonist of cell death
BAG2 BCL2-associated athanogene 2
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BCL2 B-cell CLL/lymphoma 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BIK BCL2-interacting killer (apoptosis-inducing)
BLVRA biliverdin reductase A
BMI1 BMI1 proto-oncogene, polycomb ring finger
BMPR1A bone morphogenetic protein receptor, type IA
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
BMX BMX non-receptor tyrosine kinase
BRAF B-Raf proto-oncogene, serine/threonine kinase
BTK Bruton agammaglobulinemia tyrosine kinase
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CALD1 caldesmon 1
CAMK1 calcium/calmodulin-dependent protein kinase I
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAPN2 calpain 2, (m/II) large subunit
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCND1 cyclin D1
CD19 CD19 molecule
CD34 CD34 molecule
CD79A CD79a molecule, immunoglobulin-associated alpha
CDCA5 cell division cycle associated 5
CDH5 cadherin 5, type 2 (vascular endothelium)
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDK5 cyclin-dependent kinase 5
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDX2 caudal type homeobox 2
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CFL1 cofilin 1 (non-muscle)
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CHUK conserved helix-loop-helix ubiquitous kinase
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
CREB1 cAMP responsive element binding protein 1
CREBBP CREB binding protein
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CROCC ciliary rootlet coiled-coil, rootletin
CRYAB crystallin, alpha B
CSF1R colony stimulating factor 1 receptor
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CXCR4 chemokine (C-X-C motif) receptor 4
DAB2IP DAB2 interacting protein
DAPK1 death-associated protein kinase 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DAXX death-domain associated protein
DISC1 disrupted in schizophrenia 1
DIXDC1 DIX domain containing 1
DLG2 discs, large homolog 2 (Drosophila)
DLG4 discs, large homolog 4 (Drosophila)
DNM1L dynamin 1-like
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DOK2 docking protein 2, 56kDa
DUPD1 dual specificity phosphatase and pro isomerase domain containing 1
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EEF2 eukaryotic translation elongation factor 2
EEF2K eukaryotic elongation factor 2 kinase
EGFR epidermal growth factor receptor
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EIF4B eukaryotic translation initiation factor 4B
EIF4E eukaryotic translation initiation factor 4E
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3
ELAVL1 ELAV like RNA binding protein 1
ELF4 E74-like factor 4 (ets domain transcription factor)
ELK1 ELK1, member of ETS oncogene family
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)
EP300 E1A binding protein p300
EPOR erythropoietin receptor
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
ETV1 ets variant 1
ETV6 ets variant 6
EWSR1 EWS RNA-binding protein 1
EXOC7 exocyst complex component 7
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
EZR ezrin
F3 coagulation factor III (thromboplastin, tissue factor)
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FLNA filamin A, alpha
FLRT1 fibronectin leucine rich transmembrane protein 1
FLT3 fms-related tyrosine kinase 3
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXC1 forkhead box C1
FOXM1 forkhead box M1
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FOXO4 forkhead box O4
FSCN1 fascin actin-bundling protein 1
FTH1 ferritin, heavy polypeptide 1
FYB FYN binding protein
FYN FYN proto-oncogene, Src family tyrosine kinase
GAB1 GRB2-associated binding protein 1
GAB2 GRB2-associated binding protein 2
GAP43 growth associated protein 43
GATA1 GATA binding protein 1 (globin transcription factor 1)
GATA4 GATA binding protein 4
GFAP glial fibrillary acidic protein
GJA1 gap junction protein, alpha 1, 43kDa
GRB2 growth factor receptor-bound protein 2
GRIA1 glutamate receptor, ionotropic, AMPA 1
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
H2AFX H2A histone family, member X
H3F3A H3 histone, family 3A
H3F3B H3 histone, family 3B (H3.3B)
HAND1 heart and neural crest derivatives expressed 1
HBP1 HMG-box transcription factor 1
HDAC5 histone deacetylase 5
HIST1H3A histone cluster 1, H3a
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HSPB1 heat shock 27kDa protein 1
IGF1R insulin-like growth factor 1 receptor
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL22RA1 interleukin 22 receptor, alpha 1
IL6ST interleukin 6 signal transducer
IL7R interleukin 7 receptor
INSR insulin receptor
IP6K2 inositol hexakisphosphate kinase 2
IQGAP1 IQ motif containing GTPase activating protein 1
IRAK1 interleukin-1 receptor-associated kinase 1
IRF3 interferon regulatory factor 3
IRS1 insulin receptor substrate 1
IRX2 iroquois homeobox 2
ITGB4 integrin, beta 4
JAK2 Janus kinase 2
JDP2 Jun dimerization protein 2
JUN jun proto-oncogene
KALRN kalirin, RhoGEF kinase
KARS lysyl-tRNA synthetase
KAT5 K(lysine) acetyltransferase 5
KAT7 K(lysine) acetyltransferase 7
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2
KDR kinase insert domain receptor
KIDINS220 kinase D-interacting substrate, 220kDa
KIRREL kin of IRRE like (Drosophila)
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLC2 kinesin light chain 2
KLF4 Kruppel-like factor 4 (gut)
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT8 keratin 8, type II
KSR1 kinase suppressor of ras 1
KSR2 kinase suppressor of ras 2
L1CAM L1 cell adhesion molecule
LAT linker for activation of T cells
LAT2 linker for activation of T cells family, member 2
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LEPR leptin receptor
LGALS3 lectin, galactoside-binding, soluble, 3
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LIMK1 LIM domain kinase 1
LIPE lipase, hormone-sensitive
LPCAT2 lysophosphatidylcholine acyltransferase 2
LRP6 low density lipoprotein receptor-related protein 6
LYN LYN proto-oncogene, Src family tyrosine kinase
MACF1 microtubule-actin crosslinking factor 1
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAP2K3 mitogen-activated protein kinase kinase 3
MAP2K4 mitogen-activated protein kinase kinase 4
MAP2K6 mitogen-activated protein kinase kinase 6
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MAP3K3 mitogen-activated protein kinase kinase kinase 3
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAPK1 mitogen-activated protein kinase 1
MAPK10 mitogen-activated protein kinase 10
MAPK12 mitogen-activated protein kinase 12
MAPK14 mitogen-activated protein kinase 14
MAPK15 mitogen-activated protein kinase 15
MAPK3 mitogen-activated protein kinase 3
MAPK4 mitogen-activated protein kinase 4
MAPK6 mitogen-activated protein kinase 6
MAPK7 mitogen-activated protein kinase 7
MAPK8 mitogen-activated protein kinase 8
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MAPK9 mitogen-activated protein kinase 9
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MAPT microtubule-associated protein tau
MARCKS myristoylated alanine-rich protein kinase C substrate
MAZ MYC-associated zinc finger protein (purine-binding transcription factor)
MCL1 myeloid cell leukemia 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEF2A myocyte enhancer factor 2A
MEF2C myocyte enhancer factor 2C
MELK maternal embryonic leucine zipper kinase
METTL1 methyltransferase like 1
MITF microphthalmia-associated transcription factor
MKNK1 MAP kinase interacting serine/threonine kinase 1
MKNK2 MAP kinase interacting serine/threonine kinase 2
MME membrane metallo-endopeptidase
MPL MPL proto-oncogene, thrombopoietin receptor
MST1R macrophage stimulating 1 receptor
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH9 myosin, heavy chain 9, non-muscle
MYL12B myosin, light chain 12B, regulatory
MYL9 myosin, light chain 9, regulatory
MYLK myosin light chain kinase
MYOD1 myogenic differentiation 1
MZF1 myeloid zinc finger 1
NBN nibrin
NCOA1 nuclear receptor coactivator 1
NCOA3 nuclear receptor coactivator 3
NDFIP2 Nedd4 family interacting protein 2
NDRG1 N-myc downstream regulated 1
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEUROD1 neuronal differentiation 1
NEUROG1 neurogenin 1
NEUROG2 neurogenin 2
NF2 neurofibromin 2 (merlin)
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX3-1 NK3 homeobox 1
NOS3 nitric oxide synthase 3 (endothelial cell)
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NR2C1 nuclear receptor subfamily 2, group C, member 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A1 nuclear receptor subfamily 4, group A, member 1
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OLIG2 oligodendrocyte lineage transcription factor 2
OPRK1 opioid receptor, kappa 1
OSMR oncostatin M receptor
OXSR1 oxidative stress responsive 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
PARP1 poly (ADP-ribose) polymerase 1
PBK PDZ binding kinase
PDE6G phosphodiesterase 6G, cGMP-specific, rod, gamma
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1
PEA15 phosphoprotein enriched in astrocytes 15
PELP1 proline, glutamate and leucine rich protein 1
PGR progesterone receptor
PIAS2 protein inhibitor of activated STAT, 2
PITPNB phosphatidylinositol transfer protein, beta
PKDCC protein kinase domain containing, cytoplasmic
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLK1 polo-like kinase 1
PML promyelocytic leukemia
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
POU4F1 POU class 4 homeobox 1
POU5F1 POU class 5 homeobox 1
PPARA peroxisome proliferator-activated receptor alpha
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP1R12C protein phosphatase 1, regulatory subunit 12C
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PRKCE protein kinase C, epsilon
PRKCZ protein kinase C, zeta
PRKD1 protein kinase D1
PRL prolactin
PRLR prolactin receptor
PROM1 prominin 1
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTPN3 protein tyrosine phosphatase, non-receptor type 3
PTPN5 protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTTG1 pituitary tumor-transforming 1
PXN paxillin
RAD9A RAD9 homolog A (S. pombe)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1
RARA retinoic acid receptor, alpha
RB1 retinoblastoma 1
RBM4 RNA binding motif protein 4
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RET ret proto-oncogene
RGS19 regulator of G-protein signaling 19
RNF2 ring finger protein 2
RPA2 replication protein A2, 32kDa
RPS6 ribosomal protein S6
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RPTOR regulatory associated protein of MTOR, complex 1
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
RUNX1 runt-related transcription factor 1
RUNX2 runt-related transcription factor 2
RXRA retinoid X receptor, alpha
S100A9 S100 calcium binding protein A9
SCNN1B sodium channel, non voltage gated 1 beta subunit
SCNN1G sodium channel, non voltage gated 1 gamma subunit
SETDB1 SET domain, bifurcated 1
SFN stratifin
SGK1 serum/glucocorticoid regulated kinase 1
SH2B3 SH2B adaptor protein 3
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SH3GL1 SH3-domain GRB2-like 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHC3 SHC (Src homology 2 domain containing) transforming protein 3
SIK1 salt-inducible kinase 1
SIRT1 sirtuin 1
SKAP1 src kinase associated phosphoprotein 1
SKAP2 src kinase associated phosphoprotein 2
SLAMF1 signaling lymphocytic activation molecule family member 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SMAD1 SMAD family member 1
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SMAD5 SMAD family member 5
SMAD7 SMAD family member 7
SMAD9 SMAD family member 9
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SNAI1 snail family zinc finger 1
SOS1 son of sevenless homolog 1 (Drosophila)
SOX2 SRY (sex determining region Y)-box 2
SOX9 SRY (sex determining region Y)-box 9
SP1 Sp1 transcription factor
SP3 Sp3 transcription factor
SPI1 Spi-1 proto-oncogene
SPRED1 sprouty-related, EVH1 domain containing 1
SPRY2 sprouty homolog 2 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SREBF1 sterol regulatory element binding transcription factor 1
SREBF2 sterol regulatory element binding transcription factor 2
SRF serum response factor (c-fos serum response element-binding transcription factor)
SRPK1 SRSF protein kinase 1
SSB Sjogren syndrome antigen B (autoantigen La)
STAP2 signal transducing adaptor family member 2
STAR steroidogenic acute regulatory protein
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STIM1 stromal interaction molecule 1
STK11 serine/threonine kinase 11
STK24 serine/threonine kinase 24
STK39 serine threonine kinase 39
STMN1 stathmin 1
STMN2 stathmin 2
STRAP serine/threonine kinase receptor associated protein
SYK spleen tyrosine kinase
SYN1 synapsin I
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAL1 T-cell acute lymphocytic leukemia 1
TAOK2 TAO kinase 2
TBX2 T-box 2
TCP1 t-complex 1
TEK TEK tyrosine kinase, endothelial
TFEB transcription factor EB
TFRC transferrin receptor
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THOC5 THO complex 5
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLR8 toll-like receptor 8
TP53 tumor protein p53
TP63 tumor protein p63
TPM1 tropomyosin 1 (alpha)
TSC2 tuberous sclerosis 2
TWIST1 twist family bHLH transcription factor 1
WASF2 WAS protein family, member 2
WNK1 WNK lysine deficient protein kinase 1
WWC1 WW and C2 domain containing 1
WWTR1 WW domain containing transcription regulator 1
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
YAP1 Yes-associated protein 1
YBX1 Y box binding protein 1
YES1 YES proto-oncogene 1, Src family tyrosine kinase
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZBTB16 zinc finger and BTB domain containing 16
ZFP36 ZFP36 ring finger protein
ZFYVE16 zinc finger, FYVE domain containing 16