malignant neoplasm of the central nervous system Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0100836
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Genes

159 genes associated with the malignant neoplasm of the central nervous system phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
BARD1 BRCA1 associated RING domain 1 0.650124
TERT telomerase reverse transcriptase 0.622914
CASC15 cancer susceptibility candidate 15 (non-protein coding) 0.578849
LMO1 LIM domain only 1 (rhombotin 1) 0.539271
CDKN2B-AS1 CDKN2B antisense RNA 1 0.539271
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 0.506087
SLC25A24 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24 0.432007
RTEL1 regulator of telomere elongation helicase 1 0.41534
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 0.405929
PHLDB1 pleckstrin homology-like domain, family B, member 1 0.404013
LRP1B low density lipoprotein receptor-related protein 1B 0.389189
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.384933
KIF26B kinesin family member 26B 0.379389
DGKI diacylglycerol kinase, iota 0.378487
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.37786
MGMT O-6-methylguanine-DNA methyltransferase 0.376528
LIN28B lin-28 homolog B (C. elegans) 0.376528
SMYD3 SET and MYND domain containing 3 0.368614
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 0.368175
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 0.364866
EGFR epidermal growth factor receptor 0.363982
DBT dihydrolipoamide branched chain transacylase E2 0.358764
RSRC1 arginine/serine-rich coiled-coil 1 0.35273
TRAF5 TNF receptor-associated factor 5 0.350894
CPZ carboxypeptidase Z 0.349017
XPO4 exportin 4 0.348694
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 0.347908
ACOT11 acyl-CoA thioesterase 11 0.346242
SSBP2 single-stranded DNA binding protein 2 0.34437
IKZF1 IKAROS family zinc finger 1 (Ikaros) 0.341519
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.338083
MIR205HG MIR205 host gene 0.335319
CALCOCO2 calcium binding and coiled-coil domain 2 0.332032
KAZN kazrin, periplakin interacting protein 0.330552
IL31RA interleukin 31 receptor A 0.330552
DNAH7 dynein, axonemal, heavy chain 7 0.330473
LRRC69 leucine rich repeat containing 69 0.329828
TIAM1 T-cell lymphoma invasion and metastasis 1 0.329105
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 0.328755
USP10 ubiquitin specific peptidase 10 0.328434
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2 0.328434
KAT2B K(lysine) acetyltransferase 2B 0.326976
LINC00189 long intergenic non-protein coding RNA 189 0.325689
DCC DCC netrin 1 receptor 0.324368
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 0.323415
CCDC23 coiled-coil domain containing 23 0.323415
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 0.32254
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.322127
RLF rearranged L-myc fusion 0.322127
MORC3 MORC family CW-type zinc finger 3 0.321252
OGFRL1 opioid growth factor receptor-like 1 0.320705
FRMD8 FERM domain containing 8 0.320529
PCSK6 proprotein convertase subtilisin/kexin type 6 0.318539
IQSEC3 IQ motif and Sec7 domain 3 0.317304
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.317112
STIM2 stromal interaction molecule 2 0.316197
PLD5 phospholipase D family, member 5 0.316081
SLC39A10 solute carrier family 39 (zinc transporter), member 10 0.315628
MAN1B1 mannosidase, alpha, class 1B, member 1 0.315572
SHROOM3 shroom family member 3 0.315287
LOC146513 uncharacterized LOC146513 0.315287
ZMYND15 zinc finger, MYND-type containing 15 0.314499
TTYH1 tweety family member 1 0.313108
HIAT1 hippocampus abundant transcript 1 0.31305
LOC100507195 uncharacterized LOC100507195 0.31288
DRD1 dopamine receptor D1 0.312545
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae) 0.311953
SPHKAP SPHK1 interactor, AKAP domain containing 0.311286
BTNL2 butyrophilin-like 2 0.311087
JARID2 jumonji, AT rich interactive domain 2 0.31094
STK4 serine/threonine kinase 4 0.310794
ALKBH6 alkB, alkylation repair homolog 6 (E. coli) 0.310089
PEX14 peroxisomal biogenesis factor 14 0.309596
SASS6 spindle assembly 6 homolog (C. elegans) 0.309552
DOCK1 dedicator of cytokinesis 1 0.309421
RPRD2 regulation of nuclear pre-mRNA domain containing 2 0.308993
CLIP3 CAP-GLY domain containing linker protein 3 0.30866
NXPH1 neurexophilin 1 0.308619
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.308296
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.30686
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae) 0.30686
PNLIP pancreatic lipase 0.306753
SCARB1 scavenger receptor class B, member 1 0.306612
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 0.306507
GLCCI1 glucocorticoid induced 1 0.305598
PTPRO protein tyrosine phosphatase, receptor type, O 0.305598
PAQR5 progestin and adipoQ receptor family member V 0.305533
GPA33 glycoprotein A33 (transmembrane) 0.305501
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.305057
AIFM2 apoptosis-inducing factor, mitochondrion-associated, 2 0.304718
SP100 SP100 nuclear antigen 0.304537
ATF6 activating transcription factor 6 0.304537
NRSN1 neurensin 1 0.303922
NKAIN3 Na+/K+ transporting ATPase interacting 3 0.303894
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10 0.30378
GTSF1 gametocyte specific factor 1 0.303639
RNF168 ring finger protein 168, E3 ubiquitin protein ligase 0.303445
IRF4 interferon regulatory factor 4 0.303363
FAM13A family with sequence similarity 13, member A 0.303145
DPH6 diphthamine biosynthesis 6 0.302985
TOX thymocyte selection-associated high mobility group box 0.302905
MRPL23 mitochondrial ribosomal protein L23 0.302113
FOXP1 forkhead box P1 0.302113
SH3YL1 SH3 and SYLF domain containing 1 0.30202
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.301383
OR2M7 olfactory receptor, family 2, subfamily M, member 7 0.301353
ABCC13 ATP-binding cassette, sub-family C (CFTR/MRP), member 13, pseudogene 0.301059
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense 0.300972
MAMDC2 MAM domain containing 2 0.300885
LOC285768 uncharacterized LOC285768 0.300599
LEPR leptin receptor 0.300486
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.300124
SDK1 sidekick cell adhesion molecule 1 0.300015
KCTD10 potassium channel tetramerization domain containing 10 0.299987
MED13L mediator complex subunit 13-like 0.299798
PPA2 pyrophosphatase (inorganic) 2 0.299664
PARD3B par-3 family cell polarity regulator beta 0.299399
KCNK10 potassium channel, two pore domain subfamily K, member 10 0.299294
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.298932
ANKAR ankyrin and armadillo repeat containing 0.298381
SLC38A9 solute carrier family 38, member 9 0.298039
UBE3B ubiquitin protein ligase E3B 0.297823
ARHGAP26 Rho GTPase activating protein 26 0.2978
DLG2 discs, large homolog 2 (Drosophila) 0.29747
PARK2 parkin RBR E3 ubiquitin protein ligase 0.297262
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 0.297216
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 0.297102
PITPNM3 PITPNM family member 3 0.297034
DOCK5 dedicator of cytokinesis 5 0.29672
CDH23 cadherin-related 23 0.296434
TTLL6 tubulin tyrosine ligase-like family member 6 0.29626
TMEM222 transmembrane protein 222 0.295856
CEP128 centrosomal protein 128kDa 0.295523
SFTA3 surfactant associated 3 0.295502
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila) 0.294799
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive) 0.29472
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) 0.294661
VWA3B von Willebrand factor A domain containing 3B 0.294661
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 0.294603
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 0.294506
AADACL3 arylacetamide deacetylase-like 3 0.294353
SRBD1 S1 RNA binding domain 1 0.294087
PLSCR3 phospholipid scramblase 3 0.293789
ARID1A AT rich interactive domain 1A (SWI-like) 0.293642
INSC inscuteable homolog (Drosophila) 0.293425
MSRA methionine sulfoxide reductase A 0.293281
EXT1 exostosin glycosyltransferase 1 0.293192
SPP2 secreted phosphoprotein 2, 24kDa 0.293174
LOXHD1 lipoxygenase homology domains 1 0.293121
MARCH1 membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase 0.293086
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.292858
SLIT3 slit homolog 3 (Drosophila) 0.292737
MVK mevalonate kinase 0.292737
MROH2A maestro heat-like repeat family member 2A 0.292668
RAI1 retinoic acid induced 1 0.292599
MTUS1 microtubule associated tumor suppressor 1 0.292328
ADGRB3 adhesion G protein-coupled receptor B3 0.292311
SASH1 SAM and SH3 domain containing 1 0.291963
ONECUT2 one cut homeobox 2 0.291832