machinery Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

444 genes co-occuring with the biological term machinery in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11
ACKR2 atypical chemokine receptor 2
ACTR5 ARP5 actin-related protein 5 homolog (yeast)
ADA adenosine deaminase
AFG3L2 AFG3-like AAA ATPase 2
AGTR1 angiotensin II receptor, type 1
AICDA activation-induced cytidine deaminase
ALYREF Aly/REF export factor
AMBP alpha-1-microglobulin/bikunin precursor
AMBRA1 autophagy/beclin-1 regulator 1
ANO5 anoctamin 5
ANXA1 annexin A1
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
APAF1 apoptotic peptidase activating factor 1
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
APOB apolipoprotein B
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
APTX aprataxin
AQP2 aquaporin 2 (collecting duct)
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ATF4 activating transcription factor 4
ATG14 autophagy related 14
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
AUP1 ancient ubiquitous protein 1
AURKB aurora kinase B
AVPR2 arginine vasopressin receptor 2
BACE1 beta-site APP-cleaving enzyme 1
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BAD BCL2-associated agonist of cell death
BAK1 BCL2-antagonist/killer 1
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BECN1 beclin 1, autophagy related
BIRC2 baculoviral IAP repeat containing 2
BIRC5 baculoviral IAP repeat containing 5
BMF Bcl2 modifying factor
BMP2 bone morphogenetic protein 2
BRCA1 breast cancer 1, early onset
BRE brain and reproductive organ-expressed (TNFRSF1A modulator)
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
C6ORF89 chromosome 6 open reading frame 89
C9ORF142 chromosome 9 open reading frame 142
CA9 carbonic anhydrase IX
CASP8AP2 caspase 8 associated protein 2
CBX4 chromobox homolog 4
CCAR2 cell cycle and apoptosis regulator 2
CCS copper chaperone for superoxide dismutase
CD244 CD244 molecule, natural killer cell receptor 2B4
CD3G CD3g molecule, gamma (CD3-TCR complex)
CD40 CD40 molecule, TNF receptor superfamily member 5
CD44 CD44 molecule (Indian blood group)
CD63 CD63 molecule
CD83 CD83 molecule
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDK1 cyclin-dependent kinase 1
CDK11B cyclin-dependent kinase 11B
CDK2 cyclin-dependent kinase 2
CDK7 cyclin-dependent kinase 7
CDK9 cyclin-dependent kinase 9
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CEP164 centrosomal protein 164kDa
CEP63 centrosomal protein 63kDa
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CHGA chromogranin A
CHMP1A charged multivesicular body protein 1A
CLDN16 claudin 16
CLOCK clock circadian regulator
CLSPN claspin
CLTC clathrin, heavy chain (Hc)
COL1A1 collagen, type I, alpha 1
COL2A1 collagen, type II, alpha 1
CP ceruloplasmin (ferroxidase)
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2B casein kinase 2, beta polypeptide
CST7 cystatin F (leukocystatin)
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNND1 catenin (cadherin-associated protein), delta 1
CTSD cathepsin D
CTTN cortactin
CUL4A cullin 4A
CXCL8 chemokine (C-X-C motif) ligand 8
CXXC1 CXXC finger protein 1
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DCX doublecortin
DDB1 damage-specific DNA binding protein 1, 127kDa
DDR1 discoidin domain receptor tyrosine kinase 1
DDX20 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20
DEFB103B defensin, beta 103B
DGKZ diacylglycerol kinase, zeta
DICER1 dicer 1, ribonuclease type III
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10
DNM1 dynamin 1
DNM1L dynamin 1-like
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DNPEP aspartyl aminopeptidase
DPP4 dipeptidyl-peptidase 4
DPYD dihydropyrimidine dehydrogenase
DROSHA drosha, ribonuclease type III
DST dystonin
DYNLT1 dynein, light chain, Tctex-type 1
EDC3 enhancer of mRNA decapping 3
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EGFR epidermal growth factor receptor
EGLN1 egl-9 family hypoxia-inducible factor 1
EGR1 early growth response 1
EIF2A eukaryotic translation initiation factor 2A, 65kDa
EIF3E eukaryotic translation initiation factor 3, subunit E
EIF3G eukaryotic translation initiation factor 3, subunit G
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELAVL1 ELAV like RNA binding protein 1
ENKUR enkurin, TRPC channel interacting protein
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
EP300 E1A binding protein p300
EP400 E1A binding protein p400
EPOR erythropoietin receptor
ERBB2 erb-b2 receptor tyrosine kinase 2
ERCC1 excision repair cross-complementation group 1
ERCC6 excision repair cross-complementation group 6
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
ESRRB estrogen-related receptor beta
EVI5 ecotropic viral integration site 5
EXOC6 exocyst complex component 6
EXOSC5 exosome component 5
EZR ezrin
F3 coagulation factor III (thromboplastin, tissue factor)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
FAM103A1 family with sequence similarity 103, member A1
FBXW5 F-box and WD repeat domain containing 5
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FDX1L ferredoxin 1-like
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FKBP4 FK506 binding protein 4, 59kDa
FLNA filamin A, alpha
FOXO1 forkhead box O1
FXN frataxin
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2
GALNS galactosamine (N-acetyl)-6-sulfatase
GATA1 GATA binding protein 1 (globin transcription factor 1)
GCC1 GRIP and coiled-coil domain containing 1
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3
GLTSCR2 glioma tumor suppressor candidate region gene 2
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GRB10 growth factor receptor-bound protein 10
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GUCY2D guanylate cyclase 2D, membrane (retina-specific)
H2AFX H2A histone family, member X
H2AFZ H2A histone family, member Z
HDAC1 histone deacetylase 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIP1R huntingtin interacting protein 1 related
HLA-A major histocompatibility complex, class I, A
HMGA1 high mobility group AT-hook 1
HMGB1 high mobility group box 1
HMMR hyaluronan-mediated motility receptor (RHAMM)
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA4 heat shock 70kDa protein 4
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPH1 heat shock 105kDa/110kDa protein 1
HTT huntingtin
HUS1 HUS1 checkpoint homolog (S. pombe)
IFNG interferon, gamma
IGF2 insulin-like growth factor 2
IL15 interleukin 15
IL2RB interleukin 2 receptor, beta
IL6ST interleukin 6 signal transducer
IRAK2 interleukin-1 receptor-associated kinase 2
IRF3 interferon regulatory factor 3
ISG15 ISG15 ubiquitin-like modifier
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
JAK2 Janus kinase 2
JPH1 junctophilin 1
JPH2 junctophilin 2
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KDM1A lysine (K)-specific demethylase 1A
KHSRP KH-type splicing regulatory protein
KIN Kin17 DNA and RNA binding protein
KITLG KIT ligand
KMT2A lysine (K)-specific methyltransferase 2A
KMT2E lysine (K)-specific methyltransferase 2E
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KPNB1 karyopherin (importin) beta 1
KRTCAP2 keratinocyte associated protein 2
LAT linker for activation of T cells
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LDLR low density lipoprotein receptor
LDLRAP1 low density lipoprotein receptor adaptor protein 1
LEP leptin
LGALS1 lectin, galactoside-binding, soluble, 1
LIG1 ligase I, DNA, ATP-dependent
LIG4 ligase IV, DNA, ATP-dependent
LMAN1 lectin, mannose-binding, 1
LMNA lamin A/C
LPP LIM domain containing preferred translocation partner in lipoma
MAD2L1BP MAD2L1 binding protein
MAL mal, T-cell differentiation protein
MAP1LC3A microtubule-associated protein 1 light chain 3 alpha
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MBD2 methyl-CpG binding domain protein 2
MCFD2 multiple coagulation factor deficiency 2
MCL1 myeloid cell leukemia 1
MCM7 minichromosome maintenance complex component 7
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEN1 multiple endocrine neoplasia I
MICU1 mitochondrial calcium uptake 1
MIR30A microRNA 30a
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MTRF1 mitochondrial translational release factor 1
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYO5B myosin VB
MYOF myoferlin
NANOG Nanog homeobox
NBN nibrin
NCK1 NCK adaptor protein 1
NCL nucleolin
NCOA3 nuclear receptor coactivator 3
NDFIP2 Nedd4 family interacting protein 2
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NEXN nexilin (F actin binding protein)
NINL ninein-like
NME2 NME/NM23 nucleoside diphosphate kinase 2
NPHS1 nephrosis 1, congenital, Finnish type (nephrin)
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRXN1 neurexin 1
NSF N-ethylmaleimide-sensitive factor
NSUN2 NOP2/Sun RNA methyltransferase family, member 2
NT5E 5'-nucleotidase, ecto (CD73)
NUDT16 nudix (nucleoside diphosphate linked moiety X)-type motif 16
NUS1 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae)
OPA1 optic atrophy 1 (autosomal dominant)
ORC1 origin recognition complex, subunit 1
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin
OSBPL3 oxysterol binding protein-like 3
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
PALB2 partner and localizer of BRCA2
PARD6A par-6 family cell polarity regulator alpha
PARK2 parkin RBR E3 ubiquitin protein ligase
PARK7 parkinson protein 7
PARP1 poly (ADP-ribose) polymerase 1
PCDH10 protocadherin 10
PDCD6IP programmed cell death 6 interacting protein
PDX1 pancreatic and duodenal homeobox 1
PGR progesterone receptor
PGRMC1 progesterone receptor membrane component 1
PHB prohibitin
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PIAS4 protein inhibitor of activated STAT, 4
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PINK1 PTEN induced putative kinase 1
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLD2 phospholipase D2
PLEKHA3 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3
PLEKHA8 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8
PLK1 polo-like kinase 1
PML promyelocytic leukemia
PNN pinin, desmosome associated protein
PNPLA2 patatin-like phospholipase domain containing 2
PNPO pyridoxamine 5'-phosphate oxidase
PNRC2 proline-rich nuclear receptor coactivator 2
POLB polymerase (DNA directed), beta
POLH polymerase (DNA directed), eta
POLI polymerase (DNA directed) iota
POLK polymerase (DNA directed) kappa
POLL polymerase (DNA directed), lambda
POU2F1 POU class 2 homeobox 1
POU5F1 POU class 5 homeobox 1
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PPP1R14A protein phosphatase 1, regulatory (inhibitor) subunit 14A
PPP1R15B protein phosphatase 1, regulatory subunit 15B
PPP1R8 protein phosphatase 1, regulatory subunit 8
PRDM1 PR domain containing 1, with ZNF domain
PREP prolyl endopeptidase
PRF1 perforin 1 (pore forming protein)
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PSIP1 PC4 and SFRS1 interacting protein 1
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PTGES3 prostaglandin E synthase 3 (cytosolic)
PTP4A3 protein tyrosine phosphatase type IVA, member 3
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN21 protein tyrosine phosphatase, non-receptor type 21
PTPRC protein tyrosine phosphatase, receptor type, C
PUM2 pumilio RNA-binding family member 2
QDPR quinoid dihydropteridine reductase
QPCT glutaminyl-peptide cyclotransferase
RAB11A RAB11A, member RAS oncogene family
RAB27A RAB27A, member RAS oncogene family
RAB32 RAB32, member RAS oncogene family
RAB38 RAB38, member RAS oncogene family
RAB3A RAB3A, member RAS oncogene family
RAB5A RAB5A, member RAS oncogene family
RAB7A RAB7A, member RAS oncogene family
RAB8A RAB8A, member RAS oncogene family
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAD1 RAD1 checkpoint DNA exonuclease
RAD51 RAD51 recombinase
RAD9A RAD9 homolog A (S. pombe)
RAN RAN, member RAS oncogene family
RANBP9 RAN binding protein 9
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2
RASL10B RAS-like, family 10, member B
RB1 retinoblastoma 1
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1
RECQL RecQ helicase-like
RECQL5 RecQ protein-like 5
RHO rhodopsin
RPS19 ribosomal protein S19
RPS3 ribosomal protein S3
RUVBL1 RuvB-like AAA ATPase 1
SAFB scaffold attachment factor B
SALL4 spalt-like transcription factor 4
SCAMP5 secretory carrier membrane protein 5
SCYL1 SCY1-like 1 (S. cerevisiae)
SEC23B Sec23 homolog B (S. cerevisiae)
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SET SET nuclear proto-oncogene
SETD1A SET domain containing 1A
SFPQ splicing factor proline/glutamine-rich
SGK1 serum/glucocorticoid regulated kinase 1
SH2D1A SH2 domain containing 1A
SH3KBP1 SH3-domain kinase binding protein 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHH sonic hedgehog
SIRPA signal-regulatory protein alpha
SIRT7 sirtuin 7
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SMC2 structural maintenance of chromosomes 2
SNAP29 synaptosomal-associated protein, 29kDa
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SND1 staphylococcal nuclease and tudor domain containing 1
SOX7 SRY (sex determining region Y)-box 7
SP1 Sp1 transcription factor
SP110 SP110 nuclear body protein
SP3 Sp3 transcription factor
SPI1 Spi-1 proto-oncogene
SQSTM1 sequestosome 1
SRSF10 serine/arginine-rich splicing factor 10
SSRP1 structure specific recognition protein 1
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
STARD4 StAR-related lipid transfer (START) domain containing 4
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STIL SCL/TAL1 interrupting locus
STRA6 stimulated by retinoic acid 6
STX16 syntaxin 16
STX1B syntaxin 1B
STX8 syntaxin 8
STXBP2 syntaxin binding protein 2
SUMO1 small ubiquitin-like modifier 1
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae)
SYNPO synaptopodin
SYVN1 synovial apoptosis inhibitor 1, synoviolin
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TAPBP TAP binding protein (tapasin)
TBP TATA box binding protein
TCN2 transcobalamin II
TFAM transcription factor A, mitochondrial
TGFB1 transforming growth factor, beta 1
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TIMM23 translocase of inner mitochondrial membrane 23 homolog (yeast)
TIMP3 TIMP metallopeptidase inhibitor 3
TLR3 toll-like receptor 3
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast)
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast)
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TP53 tumor protein p53
TP53I3 tumor protein p53 inducible protein 3
TP73 tumor protein p73
TRAK1 trafficking protein, kinesin binding 1
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TSG101 tumor susceptibility 101
TXNDC16 thioredoxin domain containing 16
TYR tyrosinase
TYRP1 tyrosinase-related protein 1
UBD ubiquitin D
UBE2G2 ubiquitin-conjugating enzyme E2G 2
UBTF upstream binding transcription factor, RNA polymerase I
UHRF2 ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase
UNC13D unc-13 homolog D (C. elegans)
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast)
USF1 upstream transcription factor 1
USP17L2 ubiquitin specific peptidase 17-like family member 2
UVRAG UV radiation resistance associated
VAC14 Vac14 homolog (S. cerevisiae)
VAMP7 vesicle-associated membrane protein 7
VAV1 vav 1 guanine nucleotide exchange factor
VCP valosin containing protein
VPRBP Vpr (HIV-1) binding protein
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae)
VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae)
VSX2 visual system homeobox 2
WASF2 WAS protein family, member 2
WDR82 WD repeat domain 82
WIBG within bgcn homolog (Drosophila)
WTAP Wilms tumor 1 associated protein
XAF1 XIAP associated factor 1
XPO5 exportin 5
XPOT exportin, tRNA
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
ZBTB7B zinc finger and BTB domain containing 7B
ZC3HAV1 zinc finger CCCH-type, antiviral 1
ZFP36 ZFP36 ring finger protein
ZNF451 zinc finger protein 451