lysosome Gene Set

Dataset GO Cellular Component Annotations
Category structural or functional annotations
Type cellular component
Description A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. (Gene Ontology, GO_0005764)
External Link http://amigo.geneontology.org/amigo/term/GO:0005764
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Genes

232 proteins localized to the lysosome cellular component from the curated GO Cellular Component Annotations dataset.

Symbol Name
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ACE angiotensin I converting enzyme
ACP2 acid phosphatase 2, lysosomal
ACP5 acid phosphatase 5, tartrate resistant
ADA adenosine deaminase
ADAM8 ADAM metallopeptidase domain 8
ADORA3 adenosine A3 receptor
ADRB2 adrenoceptor beta 2, surface
AGA aspartylglucosaminidase
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANKRD27 ankyrin repeat domain 27 (VPS9 domain)
ANXA1 annexin A1
ANXA11 annexin A11
AP3M1 adaptor-related protein complex 3, mu 1 subunit
AP5M1 adaptor-related protein complex 5, mu 1 subunit
AP5S1 adaptor-related protein complex 5, sigma 1 subunit
APOE apolipoprotein E
AQP2 aquaporin 2 (collecting duct)
ARSA arylsulfatase A
ARSB arylsulfatase B
ARSD arylsulfatase D
ARSG arylsulfatase G
ASS1 argininosuccinate synthase 1
ATP13A2 ATPase type 13A2
AZU1 azurocidin 1
BCL10 B-cell CLL/lymphoma 10
BTK Bruton agammaglobulinemia tyrosine kinase
C9ORF72 chromosome 9 open reading frame 72
CALCRL calcitonin receptor-like
CAT catalase
CCDC115 coiled-coil domain containing 115
CD164 CD164 molecule, sialomucin
CD34 CD34 molecule
CHGA chromogranin A
CHID1 chitinase domain containing 1
CHIT1 chitinase 1 (chitotriosidase)
CHMP2B charged multivesicular body protein 2B
CLN3 ceroid-lipofuscinosis, neuronal 3
CLN5 ceroid-lipofuscinosis, neuronal 5
CPLX2 complexin 2
CPQ carboxypeptidase Q
CRHBP corticotropin releasing hormone binding protein
CTBS chitobiase, di-N-acetyl-
CTNS cystinosin, lysosomal cystine transporter
CTSA cathepsin A
CTSB cathepsin B
CTSC cathepsin C
CTSD cathepsin D
CTSF cathepsin F
CTSH cathepsin H
CTSL cathepsin L
CTSO cathepsin O
CTSS cathepsin S
CTSZ cathepsin Z
CXCR2 chemokine (C-X-C motif) receptor 2
CXCR4 chemokine (C-X-C motif) receptor 4
DNASE2 deoxyribonuclease II, lysosomal
DNASE2B deoxyribonuclease II beta
DOC2A double C2-like domains, alpha
DPP7 dipeptidyl-peptidase 7
DRAM1 DNA-damage regulated autophagy modulator 1
DRAM2 DNA-damage regulated autophagy modulator 2
EPDR1 ependymin related 1
FGFR3 fibroblast growth factor receptor 3
FNBP1 formin binding protein 1
FUCA1 fucosidase, alpha-L- 1, tissue
FUCA2 fucosidase, alpha-L- 2, plasma
FYCO1 FYVE and coiled-coil domain containing 1
GAA glucosidase, alpha; acid
GABARAP GABA(A) receptor-associated protein
GALC galactosylceramidase
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GIMAP5 GTPase, IMAP family member 5
GJA1 gap junction protein, alpha 1, 43kDa
GLA galactosidase, alpha
GLMP glycosylated lysosomal membrane protein
GOT1 glutamic-oxaloacetic transaminase 1, soluble
HAP1 huntingtin-associated protein 1
HCK HCK proto-oncogene, Src family tyrosine kinase
HLA-DOB major histocompatibility complex, class II, DO beta
HLA-DRA major histocompatibility complex, class II, DR alpha
HPS1 Hermansky-Pudlak syndrome 1
HPS4 Hermansky-Pudlak syndrome 4
HPSE heparanase
HRG histidine-rich glycoprotein
HYAL1 hyaluronoglucosaminidase 1
HYAL2 hyaluronoglucosaminidase 2
HYAL3 hyaluronoglucosaminidase 3
IFI30 interferon, gamma-inducible protein 30
IL4I1 interleukin 4 induced 1
ITM2C integral membrane protein 2C
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KIAA0226 KIAA0226
KIAA1324 KIAA1324
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LAMP1 lysosomal-associated membrane protein 1
LAMP2 lysosomal-associated membrane protein 2
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
LAMTOR4 late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
LAPTM5 lysosomal protein transmembrane 5
LAT linker for activation of T cells
LAT2 linker for activation of T cells family, member 2
LDLR low density lipoprotein receptor
LGMN legumain
LIPA lipase A, lysosomal acid, cholesterol esterase
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LRP2 low density lipoprotein receptor-related protein 2
LRRK2 leucine-rich repeat kinase 2
LYN LYN proto-oncogene, Src family tyrosine kinase
MAN2B1 mannosidase, alpha, class 2B, member 1
MANBA mannosidase, beta A, lysosomal
MARCH1 membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
MARCH3 membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
MILR1 mast cell immunoglobulin-like receptor 1
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1
MPO myeloperoxidase
MRGPRX2 MAS-related GPR, member X2
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYO5A myosin VA (heavy chain 12, myoxin)
NAAA N-acylethanolamine acid amidase
NAGA N-acetylgalactosaminidase, alpha-
NAGLU N-acetylglucosaminidase, alpha
NAPSA napsin A aspartic peptidase
NBR1 neighbor of BRCA1 gene 1
NCF1 neutrophil cytosolic factor 1
NCF2 neutrophil cytosolic factor 2
NCF4 neutrophil cytosolic factor 4, 40kDa
NEU1 sialidase 1 (lysosomal sialidase)
NEU4 sialidase 4
NPC1 Niemann-Pick disease, type C1
NPC2 Niemann-Pick disease, type C2
NPPA natriuretic peptide A
OLFM4 olfactomedin 4
PAX2 paired box 2
PCSK9 proprotein convertase subtilisin/kexin type 9
PCYOX1 prenylcysteine oxidase 1
PEBP4 phosphatidylethanolamine-binding protein 4
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLA2G15 phospholipase A2, group XV
PLA2G3 phospholipase A2, group III
PLBD1 phospholipase B domain containing 1
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PON2 paraoxonase 2
PPT1 palmitoyl-protein thioesterase 1
PPT2 palmitoyl-protein thioesterase 2
PRCP prolylcarboxypeptidase (angiotensinase C)
PRDX6 peroxiredoxin 6
PRF1 perforin 1 (pore forming protein)
PRSS16 protease, serine, 16 (thymus)
PSAPL1 prosaposin-like 1 (gene/pseudogene)
RAB12 RAB12, member RAS oncogene family
RAB14 RAB14, member RAS oncogene family
RAB27A RAB27A, member RAS oncogene family
RAB7A RAB7A, member RAS oncogene family
RAB7B RAB7B, member RAS oncogene family
RAB9A RAB9A, member RAS oncogene family
RAB9B RAB9B, member RAS oncogene family
RAMP2 receptor (G protein-coupled) activity modifying protein 2
RAMP3 receptor (G protein-coupled) activity modifying protein 3
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
RILP Rab interacting lysosomal protein
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RNASET2 ribonuclease T2
RNF152 ring finger protein 152
RNF19B ring finger protein 19B
RPTOR regulatory associated protein of MTOR, complex 1
RRAGA Ras-related GTP binding A
RRAGB Ras-related GTP binding B
RRAGC Ras-related GTP binding C
RRAGD Ras-related GTP binding D
S100A13 S100 calcium binding protein A13
SFTPB surfactant protein B
SFTPD surfactant protein D
SIAE sialic acid acetylesterase
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC38A9 solute carrier family 38, member 9
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SNAP23 synaptosomal-associated protein, 23kDa
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNX16 sorting nexin 16
SPACA3 sperm acrosome associated 3
SQSTM1 sequestosome 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRGN serglycin
STS steroid sulfatase (microsomal), isozyme S
STX3 syntaxin 3
STX7 syntaxin 7
STXBP2 syntaxin binding protein 2
SYT7 synaptotagmin VII
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1
TLR7 toll-like receptor 7
TLR9 toll-like receptor 9
TMEM150A transmembrane protein 150A
TMEM150B transmembrane protein 150B
TMEM150C transmembrane protein 150C
TMEM192 transmembrane protein 192
TMEM59 transmembrane protein 59
TMEM9 transmembrane protein 9
TMEM97 transmembrane protein 97
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TOM1L1 target of myb1 (chicken)-like 1
TPP1 tripeptidyl peptidase I
TRIP10 thyroid hormone receptor interactor 10
TYR tyrosinase
UNC13D unc-13 homolog D (C. elegans)
UNC93B1 unc-93 homolog B1 (C. elegans)
USE1 unconventional SNARE in the ER 1 homolog (S. cerevisiae)
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
USP4 ubiquitin specific peptidase 4 (proto-oncogene)
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
USP6 ubiquitin specific peptidase 6
UVRAG UV radiation resistance associated
VAMP4 vesicle-associated membrane protein 4
VMA21 VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae)
VPS16 vacuolar protein sorting 16 homolog (S. cerevisiae)
VPS18 vacuolar protein sorting 18 homolog (S. cerevisiae)
VPS33B vacuolar protein sorting 33 homolog B (yeast)
VPS36 vacuolar protein sorting 36 homolog (S. cerevisiae)
VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae)
WDR48 WD repeat domain 48
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase