lymphoblastic Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description An immature lymphocyte that has enlarged in response to antigenic stimulation.|Often referred to as a blast cell. Unlike other usages of the suffix -blast a lymphoblast is a further differentiation of a lymphocyte, T- or B-, occasioned by an antigenic stimulus. The lymphoblast usually develops by enlargement of a lymphocyte, active re-entry to the S phase of the cell cycle, mitogenesis and production of much m-RNA and ribosomes. (Experimental Factor Ontology, EFO_0000572)
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Genes

423 genes co-occuring with the biological term lymphoblastic in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACHE acetylcholinesterase (Yt blood group)
ADRB2 adrenoceptor beta 2, surface
AFF1 AF4/FMR2 family, member 1
AFF3 AF4/FMR2 family, member 3
AFF4 AF4/FMR2 family, member 4
AICDA activation-induced cytidine deaminase
AKT1 v-akt murine thymoma viral oncogene homolog 1
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B
ANPEP alanyl (membrane) aminopeptidase
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ARID5B AT rich interactive domain 5B (MRF1-like)
ARNT aryl hydrocarbon receptor nuclear translocator
ARRB1 arrestin, beta 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF5 activating transcription factor 5
ATM ATM serine/threonine kinase
AUTS2 autism susceptibility candidate 2
B3GAT1 beta-1,3-glucuronyltransferase 1
BAALC brain and acute leukemia, cytoplasmic
BCL2 B-cell CLL/lymphoma 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL2L14 BCL2-like 14 (apoptosis facilitator)
BCR breakpoint cluster region
BDNF brain-derived neurotrophic factor
BIRC2 baculoviral IAP repeat containing 2
BIRC5 baculoviral IAP repeat containing 5
BIRC7 baculoviral IAP repeat containing 7
BLACE B-cell acute lymphoblastic leukemia expressed
BLID BH3-like motif containing, cell death inducer
BLK BLK proto-oncogene, Src family tyrosine kinase
BLNK B-cell linker
BMI1 BMI1 proto-oncogene, polycomb ring finger
BMP4 bone morphogenetic protein 4
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA2 breast cancer 2, early onset
BTG1 B-cell translocation gene 1, anti-proliferative
BTK Bruton agammaglobulinemia tyrosine kinase
CA12 carbonic anhydrase XII
CALCA calcitonin-related polypeptide alpha
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP8AP2 caspase 8 associated protein 2
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCAR1 cell division cycle and apoptosis regulator 1
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCND1 cyclin D1
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR9 chemokine (C-C motif) receptor 9
CD14 CD14 molecule
CD19 CD19 molecule
CD1D CD1d molecule
CD24 CD24 molecule
CD27 CD27 molecule
CD33 CD33 molecule
CD34 CD34 molecule
CD3G CD3g molecule, gamma (CD3-TCR complex)
CD44 CD44 molecule (Indian blood group)
CD70 CD70 molecule
CD81 CD81 molecule
CD8A CD8a molecule
CD9 CD9 molecule
CDK6 cyclin-dependent kinase 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CDKN2B-AS1 CDKN2B antisense RNA 1
CDX2 caudal type homeobox 2
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon
CEP85L centrosomal protein 85kDa-like
CHST4 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
CLECL1 C-type lectin-like 1
CNOT3 CCR4-NOT transcription complex, subunit 3
COL18A1 collagen, type XVIII, alpha 1
CREBBP CREB binding protein
CREBL2 cAMP responsive element binding protein-like 2
CRLF2 cytokine receptor-like factor 2
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CSPG4 chondroitin sulfate proteoglycan 4
CTCF CCCTC-binding factor (zinc finger protein)
CTGF connective tissue growth factor
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR3 chemokine (C-X-C motif) receptor 3
CXCR4 chemokine (C-X-C motif) receptor 4
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP3A cytochrome P450, family 3, subfamily A
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DBN1 drebrin 1
DCX doublecortin
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DHFR dihydrofolate reductase
DHX32 DEAH (Asp-Glu-Ala-His) box polypeptide 32
DLL4 delta-like 4 (Drosophila)
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DNTT DNA nucleotidylexotransferase
DPH1 diphthamide biosynthesis 1
DUSP16 dual specificity phosphatase 16
EBF1 early B-cell factor 1
EED embryonic ectoderm development
EFNA5 ephrin-A5
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
ENG endoglin
ENO2 enolase 2 (gamma, neuronal)
EP300 E1A binding protein p300
EPHA3 EPH receptor A3
EPHB4 EPH receptor B4
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EPOR erythropoietin receptor
ERCC2 excision repair cross-complementation group 2
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
ETV6 ets variant 6
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F13A1 coagulation factor XIII, A1 polypeptide
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FCRL1 Fc receptor-like 1
FCRL2 Fc receptor-like 2
FCRL4 Fc receptor-like 4
FCRL5 Fc receptor-like 5
FHOD3 formin homology 2 domain containing 3
FIP1L1 factor interacting with PAPOLA and CPSF1
FLT1 fms-related tyrosine kinase 1
FLT3 fms-related tyrosine kinase 3
FLT4 fms-related tyrosine kinase 4
FOXO3 forkhead box O3
FOXO4 forkhead box O4
FOXP1 forkhead box P1
FOXP3 forkhead box P3
FPGS folylpolyglutamate synthase
FTO fat mass and obesity associated
FUS FUS RNA binding protein
GADD45A growth arrest and DNA-damage-inducible, alpha
GAS6 growth arrest-specific 6
GATA3 GATA binding protein 3
GFI1 growth factor independent 1 transcription repressor
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GIF gastric intrinsic factor (vitamin B synthesis)
GSK3B glycogen synthase kinase 3 beta
GSTM1 glutathione S-transferase mu 1
GSTO2 glutathione S-transferase omega 2
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HDAC4 histone deacetylase 4
HES1 hes family bHLH transcription factor 1
HES5 hes family bHLH transcription factor 5
HFE hemochromatosis
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-G major histocompatibility complex, class I, G
HLF hepatic leukemia factor
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HOXA11 homeobox A11
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
HSPA1A heat shock 70kDa protein 1A
HSPA1B heat shock 70kDa protein 1B
HSPA1L heat shock 70kDa protein 1-like
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGF1R insulin-like growth factor 1 receptor
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGH immunoglobulin heavy locus
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IKZF2 IKAROS family zinc finger 2 (Helios)
IL10 interleukin 10
IL15 interleukin 15
IL1RN interleukin 1 receptor antagonist
IL2RA interleukin 2 receptor, alpha
IL7 interleukin 7
IL7R interleukin 7 receptor
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
IRF4 interferon regulatory factor 4
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
JAK1 Janus kinase 1
JAK2 Janus kinase 2
JAK3 Janus kinase 3
JUN jun proto-oncogene
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNK18 potassium channel, two pore domain subfamily K, member 18
KDM6A lysine (K)-specific demethylase 6A
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLRC1 killer cell lectin-like receptor subfamily C, member 1
KMT2A lysine (K)-specific methyltransferase 2A
KRAS Kirsten rat sarcoma viral oncogene homolog
LAT2 linker for activation of T cells family, member 2
LCK LCK proto-oncogene, Src family tyrosine kinase
LEP leptin
LEPR leptin receptor
LIF leukemia inhibitory factor
LIG4 ligase IV, DNA, ATP-dependent
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
LIMS1 LIM and senescent cell antigen-like domains 1
LMO1 LIM domain only 1 (rhombotin 1)
LMO2 LIM domain only 2 (rhombotin-like 1)
LRP6 low density lipoprotein receptor-related protein 6
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPT microtubule-associated protein tau
MBL2 mannose-binding lectin (protein C) 2, soluble
MDK midkine (neurite growth-promoting factor 2)
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MECOM MDS1 and EVI1 complex locus
MEF2C myocyte enhancer factor 2C
MERTK MER proto-oncogene, tyrosine kinase
MET MET proto-oncogene, receptor tyrosine kinase
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MIR100 microRNA 100
MIR101-1 microRNA 101-1
MIR125B1 microRNA 125b-1
MIR125B2 microRNA 125b-2
MIR142 microRNA 142
MIR143 microRNA 143
MIR150 microRNA 150
MIR15A microRNA 15a
MIR16-1 microRNA 16-1
MIR182 microRNA 182
MIR196A2 microRNA 196a-2
MIR196B microRNA 196b
MIR210 microRNA 210
MIR223 microRNA 223
MIR335 microRNA 335
MIR451A microRNA 451a
MIR499A microRNA 499a
MIR502 microRNA 502
MIR612 microRNA 612
MIR9-1 microRNA 9-1
MIR9-2 microRNA 9-2
MIR9-3 microRNA 9-3
MIR99A microRNA 99a
MIRLET7B microRNA let-7b
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
MLXIP MLX interacting protein
MME membrane metallo-endopeptidase
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MNX1 motor neuron and pancreas homeobox 1
MPO myeloperoxidase
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MSI2 musashi RNA-binding protein 2
MTAP methylthioadenosine phosphorylase
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
MUTYH mutY homolog
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBN nibrin
NCAM1 neural cell adhesion molecule 1
NEWENTRY Record to support submission of GeneRIFs for a gene not in Gene (human; man).
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NKX2-1 NK2 homeobox 1
NKX2-2 NK2 homeobox 2
NKX2-5 NK2 homeobox 5
NKX3-1 NK3 homeobox 1
NNMT nicotinamide N-methyltransferase
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH1 notch 1
NOTCH3 notch 3
NQO1 NAD(P)H dehydrogenase, quinone 1
NR0B2 nuclear receptor subfamily 0, group B, member 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NRXN1 neurexin 1
NSRP1 nuclear speckle splicing regulatory protein 1
NT5C2 5'-nucleotidase, cytosolic II
NUP214 nucleoporin 214kDa
OGG1 8-oxoguanine DNA glycosylase
OPRK1 opioid receptor, kappa 1
P2RY8 purinergic receptor P2Y, G-protein coupled, 8
PARP1 poly (ADP-ribose) polymerase 1
PAWR PRKC, apoptosis, WT1, regulator
PAX2 paired box 2
PAX4 paired box 4
PAX5 paired box 5
PBX1 pre-B-cell leukemia homeobox 1
PCDH10 protocadherin 10
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PGF placental growth factor
PHB prohibitin
PHF6 PHD finger protein 6
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
PKM pyruvate kinase, muscle
PLK1 polo-like kinase 1
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PRAME preferentially expressed antigen in melanoma
PRDM2 PR domain containing 2, with ZNF domain
PRDM9 PR domain containing 9
PRF1 perforin 1 (pore forming protein)
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKCQ protein kinase C, theta
PRKCZ protein kinase C, zeta
PRL prolactin
PROM1 prominin 1
PTEN phosphatase and tensin homolog
PTK7 protein tyrosine kinase 7 (inactive)
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPRC protein tyrosine phosphatase, receptor type, C
PVR poliovirus receptor
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B)
RAD51 RAD51 recombinase
RAG1 recombination activating gene 1
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RASSF4 Ras association (RalGDS/AF-6) domain family member 4
RB1 retinoblastoma 1
RCSD1 RCSD domain containing 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RFC1 replication factor C (activator 1) 1, 145kDa
RHOU ras homolog family member U
ROR1 receptor tyrosine kinase-like orphan receptor 1
RPL10 ribosomal protein L10
RPL5 ribosomal protein L5
RUNX1 runt-related transcription factor 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SET SET nuclear proto-oncogene
SETD8 SET domain containing (lysine methyltransferase) 8
SH2B3 SH2B adaptor protein 3
SHH sonic hedgehog
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SIAE sialic acid acetylesterase
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLCO1B1 solute carrier organic anion transporter family, member 1B1
SLX4IP SLX4 interacting protein
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMYD2 SET and MYND domain containing 2
SOAT1 sterol O-acyltransferase 1
SOX11 SRY (sex determining region Y)-box 11
SP1 Sp1 transcription factor
SPRED1 sprouty-related, EVH1 domain containing 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
TACR1 tachykinin receptor 1
TAL1 T-cell acute lymphocytic leukemia 1
TARDBP TAR DNA binding protein
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TCF3 transcription factor 3
TCL1A T-cell leukemia/lymphoma 1A
TERC telomerase RNA component
TERT telomerase reverse transcriptase
TET1 tet methylcytosine dioxygenase 1
TGFB1 transforming growth factor, beta 1
THAP1 THAP domain containing, apoptosis associated protein 1
TLR6 toll-like receptor 6
TLR9 toll-like receptor 9
TLX1 T-cell leukemia homeobox 1
TLX3 T-cell leukemia homeobox 3
TNF tumor necrosis factor
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TP53 tumor protein p53
TP73 tumor protein p73
TPMT thiopurine S-methyltransferase
TRA T cell receptor alpha locus
TRD T cell receptor delta locus
TRDMT1 tRNA aspartic acid methyltransferase 1
TRG T cell receptor gamma locus
TRIB2 tribbles pseudokinase 2
TSGA10 testis specific, 10
TTC12 tetratricopeptide repeat domain 12
TWIST2 twist family bHLH transcription factor 2
TYK2 tyrosine kinase 2
TYMS thymidylate synthetase
UBE2Q2 ubiquitin-conjugating enzyme E2Q family member 2
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
UHMK1 U2AF homology motif (UHM) kinase 1
VEGFA vascular endothelial growth factor A
WT1 Wilms tumor 1
XBP1 X-box binding protein 1
XPA xeroderma pigmentosum, complementation group A
XPC xeroderma pigmentosum, complementation group C
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZFX zinc finger protein, X-linked
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF296 zinc finger protein 296
ZNF423 zinc finger protein 423