lubac complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A ubiquitin ligase complex that catalyzes linear head-to-tail polyubiquitin conjugation on its targets. In human the complex consists of RBCK1, RNF31 and SHARPIN, and has an MW of approximately 600 kDa, suggesting a heteromultimeric assembly of its subunits. LUBAC stands for Linear Ubiquitin Chain Assembly Complex. (Gene Ontology, GO_0071797)
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Genes

44 proteins co-occuring with the lubac complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
RNF31 ring finger protein 31 2.8698
SHARPIN SHANK-associated RH domain interactor 2.74145
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 2.36174
OTULIN OTU deubiquitinase with linear linkage specificity 1.76303
GZMM granzyme M (lymphocyte met-ase 1) 1.4125
CYLD cylindromatosis (turban tumor syndrome) 1.19314
UBD ubiquitin D 1.16901
TRIM25 tripartite motif containing 25 1.13114
RNF125 ring finger protein 125, E3 ubiquitin protein ligase 1.10664
RIPK2 receptor-interacting serine-threonine kinase 2 1.01784
RNF135 ring finger protein 135 0.97565
UBE2N ubiquitin-conjugating enzyme E2N 0.869046
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.846532
PHF20 PHD finger protein 20 0.844237
RING1 ring finger protein 1 0.841482
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.804772
SH2D1A SH2 domain containing 1A 0.748641
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) 0.739614
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.690326
NOD2 nucleotide-binding oligomerization domain containing 2 0.67463
USP15 ubiquitin specific peptidase 15 0.668992
CARD11 caspase recruitment domain family, member 11 0.654741
MALT1 MALT1 paracaspase 0.645287
TNF tumor necrosis factor 0.604017
BCL10 B-cell CLL/lymphoma 10 0.565092
BIRC2 baculoviral IAP repeat containing 2 0.500258
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.460401
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 0.440124
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.419252
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.336241
PARK2 parkin RBR E3 ubiquitin protein ligase 0.334356
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 0.285876
UBC ubiquitin C 0.282926
RPS27A ribosomal protein S27a 0.260566
UBB ubiquitin B 0.246407
NOD1 nucleotide-binding oligomerization domain containing 1 0.241356
SUMO3 small ubiquitin-like modifier 3 0.231672
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.218914
SUMO2 small ubiquitin-like modifier 2 0.21716
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.212974
MAVS mitochondrial antiviral signaling protein 0.20574
UBE2K ubiquitin-conjugating enzyme E2K 0.188905
TRAF3 TNF receptor-associated factor 3 0.184547
UBE2S ubiquitin-conjugating enzyme E2S 0.171937