low-density lipoprotein particle Gene Set

Dataset GO Cellular Component Annotations
Category structural or functional annotations
Type cellular component
Description A lipoprotein particle, rich in cholesterol esters and low in triglycerides that is typically composed of APOB100 and APOE and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. LDL particles are formed from VLDL particles (via IDL) by the loss of triglyceride and gain of cholesterol ester. They transport endogenous cholesterol (and to some extent triglycerides) from peripheral tissues back to the liver. (Gene Ontology, GO_0034362)
External Link http://amigo.geneontology.org/amigo/term/GO:0034362
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Genes

14 proteins localized to the low-density lipoprotein particle cellular component from the curated GO Cellular Component Annotations dataset.

Symbol Name
APOA5 apolipoprotein A-V
APOB apolipoprotein B
APOBR apolipoprotein B receptor
APOC2 apolipoprotein C-II
APOE apolipoprotein E
APOF apolipoprotein F
APOM apolipoprotein M
APOO apolipoprotein O
LDLR low density lipoprotein receptor
LSR lipolysis stimulated lipoprotein receptor
MSR1 macrophage scavenger receptor 1
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
VIMP VCP-interacting membrane selenoprotein