lobeline-6258 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the lobeline-6258 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AKAP9 A kinase (PRKA) anchor protein 9
ALOXE3 arachidonate lipoxygenase 3
ARMC4 armadillo repeat containing 4
ATG3 autophagy related 3
BMP6 bone morphogenetic protein 6
BSDC1 BSD domain containing 1
BTD biotinidase
CAMKMT calmodulin-lysine N-methyltransferase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CBX8 chromobox homolog 8
CCDC71 coiled-coil domain containing 71
CCDC93 coiled-coil domain containing 93
CLIC2 chloride intracellular channel 2
CLK1 CDC-like kinase 1
CUL4B cullin 4B
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYTH1 cytohesin 1
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
DOK4 docking protein 4
DRD2 dopamine receptor D2
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EFCAB11 EF-hand calcium binding domain 11
EGFR epidermal growth factor receptor
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)
F2RL2 coagulation factor II (thrombin) receptor-like 2
FAM13C family with sequence similarity 13, member C
FAM169A family with sequence similarity 169, member A
FBXL6 F-box and leucine-rich repeat protein 6
FCF1 FCF1 rRNA-processing protein
FCMR Fc fragment of IgM receptor
FGF2 fibroblast growth factor 2 (basic)
FKBP8 FK506 binding protein 8, 38kDa
FRK fyn-related Src family tyrosine kinase
FZD10 frizzled class receptor 10
GOLIM4 golgi integral membrane protein 4
GPR1 G protein-coupled receptor 1
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HFE hemochromatosis
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSPA1L heat shock 70kDa protein 1-like
IL1RL1 interleukin 1 receptor-like 1
JUNB jun B proto-oncogene
KAT8 K(lysine) acetyltransferase 8
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KLF6 Kruppel-like factor 6
LDB1 LIM domain binding 1
LIN7A lin-7 homolog A (C. elegans)
MAP2K5 mitogen-activated protein kinase kinase 5
MAPK13 mitogen-activated protein kinase 13
MET MET proto-oncogene, receptor tyrosine kinase
METTL7A methyltransferase like 7A
MID1 midline 1
MID2 midline 2
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
MTMR1 myotubularin related protein 1
MXD3 MAX dimerization protein 3
MYOF myoferlin
NAAA N-acylethanolamine acid amidase
NADK NAD kinase
NF2 neurofibromin 2 (merlin)
NIPAL2 NIPA-like domain containing 2
NMT2 N-myristoyltransferase 2
NPEPPS aminopeptidase puromycin sensitive
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PAX5 paired box 5
PGAP1 post-GPI attachment to proteins 1
PHC1 polyhomeotic homolog 1 (Drosophila)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
PTRF polymerase I and transcript release factor
QKI QKI, KH domain containing, RNA binding
RIN2 Ras and Rab interactor 2
RNF19B ring finger protein 19B
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
RPLP2 ribosomal protein, large, P2
SEMA4F sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F
SFXN3 sideroflexin 3
SIX1 SIX homeobox 1
SOWAHC sosondowah ankyrin repeat domain family member C
SP1 Sp1 transcription factor
SPPL2B signal peptide peptidase like 2B
STRN striatin, calmodulin binding protein
SUGP1 SURP and G patch domain containing 1
SVIL supervillin
SYN2 synapsin II
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)
TRPV1 transient receptor potential cation channel, subfamily V, member 1
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast)
USB1 U6 snRNA biogenesis 1
USP34 ubiquitin specific peptidase 34
UTRN utrophin
VPS37C vacuolar protein sorting 37 homolog C (S. cerevisiae)
WDR25 WD repeat domain 25
WDR62 WD repeat domain 62
ZKSCAN1 zinc finger with KRAB and SCAN domains 1

decreased expression

Symbol Name
ABHD14A abhydrolase domain containing 14A
ACTL8 actin-like 8
ADGRE5 adhesion G protein-coupled receptor E5
AEN apoptosis enhancing nuclease
AMDHD2 amidohydrolase domain containing 2
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
BBC3 BCL2 binding component 3
BMP15 bone morphogenetic protein 15
BTF3P12 basic transcription factor 3 pseudogene 12
CCDC25 coiled-coil domain containing 25
CEP72 centrosomal protein 72kDa
CERK ceramide kinase
CGREF1 cell growth regulator with EF-hand domain 1
CNPY3 canopy FGF signaling regulator 3
CNR2 cannabinoid receptor 2 (macrophage)
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CPPED1 calcineurin-like phosphoesterase domain containing 1
DUSP8 dual specificity phosphatase 8
EFCAB2 EF-hand calcium binding domain 2
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
ERN2 endoplasmic reticulum to nucleus signaling 2
ETHE1 ethylmalonic encephalopathy 1
F3 coagulation factor III (thromboplastin, tissue factor)
FBXO46 F-box protein 46
FLRT3 fibronectin leucine rich transmembrane protein 3
GID4 GID complex subunit 4
GLI3 GLI family zinc finger 3
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GTPBP2 GTP binding protein 2
HIRA histone cell cycle regulator
HIST1H2AM histone cluster 1, H2am
HMHA1 histocompatibility (minor) HA-1
IFT81 intraflagellar transport 81
IGSF1 immunoglobulin superfamily, member 1
IL15RA interleukin 15 receptor, alpha
IL2 interleukin 2
INO80D INO80 complex subunit D
IRF6 interferon regulatory factor 6
KDM5C lysine (K)-specific demethylase 5C
KLHL21 kelch-like family member 21
KPTN kaptin (actin binding protein)
LAMA3 laminin, alpha 3
LNPEP leucyl/cystinyl aminopeptidase
LRP3 low density lipoprotein receptor-related protein 3
LYRM9 LYR motif containing 9
MED15 mediator complex subunit 15
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MRPL52 mitochondrial ribosomal protein L52
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MYL5 myosin, light chain 5, regulatory
NPIPB15 nuclear pore complex interacting protein family, member B15
NUP62CL nucleoporin 62kDa C-terminal like
PDE12 phosphodiesterase 12
PGP phosphoglycolate phosphatase
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PMCH pro-melanin-concentrating hormone
POMT2 protein-O-mannosyltransferase 2
PQLC1 PQ loop repeat containing 1
PRPH peripherin
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PTPRU protein tyrosine phosphatase, receptor type, U
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RCOR3 REST corepressor 3
RECQL4 RecQ protein-like 4
RNF39 ring finger protein 39
S100A4 S100 calcium binding protein A4
SCGB2A2 secretoglobin, family 2A, member 2
SDF2 stromal cell-derived factor 2
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SLC12A9 solute carrier family 12, member 9
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC22A18 solute carrier family 22, member 18
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SMA4 glucuronidase, beta pseudogene
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SND1-IT1 SND1 intronic transcript 1
SPIDR scaffolding protein involved in DNA repair
STARD5 StAR-related lipid transfer (START) domain containing 5
TAGLN transgelin
TAOK1 TAO kinase 1
TPST1 tyrosylprotein sulfotransferase 1
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
USP20 ubiquitin specific peptidase 20
VASH1 vasohibin 1
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
VEGFC vascular endothelial growth factor C
VN1R1 vomeronasal 1 receptor 1
WLS wntless Wnt ligand secretion mediator
XAB2 XPA binding protein 2
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZNF219 zinc finger protein 219
ZNF280D zinc finger protein 280D
ZNF442 zinc finger protein 442
ZNF552 zinc finger protein 552
ZNF571 zinc finger protein 571