lobeline-1770 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the lobeline-1770 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADRA2B adrenoceptor alpha 2B
AGRN agrin
AIM1L absent in melanoma 1-like
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
ARHGAP44 Rho GTPase activating protein 44
ARTN artemin
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BIRC7 baculoviral IAP repeat containing 7
BMP2K BMP2 inducible kinase
C7ORF43 chromosome 7 open reading frame 43
CACFD1 calcium channel flower domain containing 1
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CACYBP calcyclin binding protein
CADM3 cell adhesion molecule 3
CCDC40 coiled-coil domain containing 40
CCZ1 CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CIITA class II, major histocompatibility complex, transactivator
CLCN7 chloride channel, voltage-sensitive 7
CLPS colipase, pancreatic
CLTA clathrin, light chain A
CNTFR ciliary neurotrophic factor receptor
COMT catechol-O-methyltransferase
CORT cortistatin
CPM carboxypeptidase M
CRTC1 CREB regulated transcription coactivator 1
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DSPP dentin sialophosphoprotein
DUSP26 dual specificity phosphatase 26 (putative)
EFR3B EFR3 homolog B (S. cerevisiae)
ERN2 endoplasmic reticulum to nucleus signaling 2
EXD3 exonuclease 3'-5' domain containing 3
F7 coagulation factor VII (serum prothrombin conversion accelerator)
FBRS fibrosin
FOXC1 forkhead box C1
FSCN1 fascin actin-bundling protein 1
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GNL1 guanine nucleotide binding protein-like 1
GPX3 glutathione peroxidase 3
HAMP hepcidin antimicrobial peptide
HOXD9 homeobox D9
IGHA1 immunoglobulin heavy constant alpha 1
IQCC IQ motif containing C
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KIF25 kinesin family member 25
KIF3C kinesin family member 3C
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
KRT8 keratin 8, type II
LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4
LIMS2 LIM and senescent cell antigen-like domains 2
LLGL1 lethal giant larvae homolog 1 (Drosophila)
METTL7A methyltransferase like 7A
MFSD11 major facilitator superfamily domain containing 11
MIIP migration and invasion inhibitory protein
MOB3B MOB kinase activator 3B
MRC2 mannose receptor, C type 2
MT3 metallothionein 3
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MYF6 myogenic factor 6 (herculin)
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle
NCR2 natural cytotoxicity triggering receptor 2
NPEPL1 aminopeptidase-like 1
OR10H1 olfactory receptor, family 10, subfamily H, member 1
PADI1 peptidyl arginine deiminase, type I
PAX2 paired box 2
PBX2 pre-B-cell leukemia homeobox 2
PHF3 PHD finger protein 3
PLCG1 phospholipase C, gamma 1
POMT2 protein-O-mannosyltransferase 2
POU5F1B POU class 5 homeobox 1B
PPARA peroxisome proliferator-activated receptor alpha
PRB1 proline-rich protein BstNI subfamily 1
PRB3 proline-rich protein BstNI subfamily 3
PRDM14 PR domain containing 14
PSEN2 presenilin 2
PTGER3 prostaglandin E receptor 3 (subtype EP3)
RAB2A RAB2A, member RAS oncogene family
RAB40B RAB40B, member RAS oncogene family
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila)
SCN5A sodium channel, voltage gated, type V alpha subunit
SFN stratifin
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC22A14 solute carrier family 22, member 14
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11
SPDEF SAM pointed domain containing ETS transcription factor
SSX3 synovial sarcoma, X breakpoint 3
TMCC2 transmembrane and coiled-coil domain family 2
TRAPPC9 trafficking protein particle complex 9
TRIM29 tripartite motif containing 29
TRMT61A tRNA methyltransferase 61A
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
TYR tyrosinase
UBTD1 ubiquitin domain containing 1
USF2 upstream transcription factor 2, c-fos interacting
VGF VGF nerve growth factor inducible
ZFHX2 zinc finger homeobox 2

decreased expression

Symbol Name
ABT1 activator of basal transcription 1
ANKFY1 ankyrin repeat and FYVE domain containing 1
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
APOC2 apolipoprotein C-II
ARL4A ADP-ribosylation factor-like 4A
BIN2 bridging integrator 2
BYSL bystin-like
C1ORF123 chromosome 1 open reading frame 123
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3
CAPN1 calpain 1, (mu/I) large subunit
CCDC130 coiled-coil domain containing 130
CCDC53 coiled-coil domain containing 53
CCL20 chemokine (C-C motif) ligand 20
CCNL2 cyclin L2
CDCA3 cell division cycle associated 3
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CLDN15 claudin 15
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
COMMD8 COMM domain containing 8
COMMD9 COMM domain containing 9
DCXR dicarbonyl/L-xylulose reductase
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DPF2 D4, zinc and double PHD fingers family 2
DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
FADS2 fatty acid desaturase 2
GALE UDP-galactose-4-epimerase
GEMIN6 gem (nuclear organelle) associated protein 6
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GOLGA3 golgin A3
GPATCH2 G patch domain containing 2
GPS2 G protein pathway suppressor 2
H1FX H1 histone family, member X
HARS histidyl-tRNA synthetase
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HN1 hematological and neurological expressed 1
HSPB1 heat shock 27kDa protein 1
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
KEAP1 kelch-like ECH-associated protein 1
LIG1 ligase I, DNA, ATP-dependent
LTA4H leukotriene A4 hydrolase
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MFSD12 major facilitator superfamily domain containing 12
MON1B MON1 secretory trafficking family member B
MRPL28 mitochondrial ribosomal protein L28
MRPS28 mitochondrial ribosomal protein S28
MRPS34 mitochondrial ribosomal protein S34
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYLIP myosin regulatory light chain interacting protein
NADSYN1 NAD synthetase 1
NAGK N-acetylglucosamine kinase
NDE1 nudE neurodevelopment protein 1
NOD1 nucleotide-binding oligomerization domain containing 1
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae)
NRBP1 nuclear receptor binding protein 1
NUP93 nucleoporin 93kDa
OIP5 Opa interacting protein 5
ORC1 origin recognition complex, subunit 1
ORC3 origin recognition complex, subunit 3
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
PAGR1 PAXIP1 associated glutamate-rich protein 1
PCNA proliferating cell nuclear antigen
PCTP phosphatidylcholine transfer protein
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PIGT phosphatidylinositol glycan anchor biosynthesis, class T
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POU2F1 POU class 2 homeobox 1
PPP4C protein phosphatase 4, catalytic subunit
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
PTOV1 prostate tumor overexpressed 1
RAB4B RAB4B, member RAS oncogene family
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RBM10 RNA binding motif protein 10
RSAD1 radical S-adenosyl methionine domain containing 1
RWDD2B RWD domain containing 2B
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SLC25A40 solute carrier family 25, member 40
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SMG9 SMG9 nonsense mediated mRNA decay factor
SNX17 sorting nexin 17
SNX6 sorting nexin 6
SP140L SP140 nuclear body protein-like
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
THOC6 THO complex 6
TMEM109 transmembrane protein 109
UBAC1 UBA domain containing 1
UBE2M ubiquitin-conjugating enzyme E2M
UFD1L ubiquitin fusion degradation 1 like (yeast)
UROS uroporphyrinogen III synthase
WBSCR16 Williams-Beuren syndrome chromosome region 16
WDR18 WD repeat domain 18
WDR6 WD repeat domain 6
YIPF1 Yip1 domain family, member 1
ZDHHC4 zinc finger, DHHC-type containing 4
ZNF426 zinc finger protein 426