lobelanidine-5500 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the lobelanidine-5500 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADGRL1 adhesion G protein-coupled receptor L1
ADRA1D adrenoceptor alpha 1D
ALDOAP2 aldolase A, fructose-bisphosphate pseudogene 2
ALDOB aldolase B, fructose-bisphosphate
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1
APOH apolipoprotein H (beta-2-glycoprotein I)
ARL4C ADP-ribosylation factor-like 4C
ATF7IP activating transcription factor 7 interacting protein
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
ATRN attractin
ATRNL1 attractin-like 1
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CADM4 cell adhesion molecule 4
CAMKV CaM kinase-like vesicle-associated
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCL27 chemokine (C-C motif) ligand 27
CCP110 centriolar coiled coil protein 110kDa
CD82 CD82 molecule
COL5A2 collagen, type V, alpha 2
COL8A1 collagen, type VIII, alpha 1
COLGALT2 collagen beta(1-O)galactosyltransferase 2
CORO2B coronin, actin binding protein, 2B
CSF1R colony stimulating factor 1 receptor
CUZD1 CUB and zona pellucida-like domains 1
DFNB31 deafness, autosomal recessive 31
DLX4 distal-less homeobox 4
EDAR ectodysplasin A receptor
EFNA3 ephrin-A3
ESR2 estrogen receptor 2 (ER beta)
FAM63A family with sequence similarity 63, member A
FGF20 fibroblast growth factor 20
FGFR1 fibroblast growth factor receptor 1
FOXG1 forkhead box G1
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GGT1 gamma-glutamyltransferase 1
GPM6B glycoprotein M6B
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GPSM3 G-protein signaling modulator 3
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HBEGF heparin-binding EGF-like growth factor
HBS1L HBS1-like translational GTPase
ICAM1 intercellular adhesion molecule 1
IGFBP5 insulin-like growth factor binding protein 5
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JAM3 junctional adhesion molecule 3
KANK1 KN motif and ankyrin repeat domains 1
KCNIP1 Kv channel interacting protein 1
KIAA1456 KIAA1456
KIF25-AS1 KIF25 antisense RNA 1
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
LIMD1 LIM domains containing 1
LOC257152 uncharacterized LOC257152
LRP4 low density lipoprotein receptor-related protein 4
LRRC23 leucine rich repeat containing 23
MEG3 maternally expressed 3 (non-protein coding)
MFAP2 microfibrillar-associated protein 2
MKL1 megakaryoblastic leukemia (translocation) 1
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
NMT1 N-myristoyltransferase 1
NUCB1 nucleobindin 1
PBOV1 prostate and breast cancer overexpressed 1
PCSK6 proprotein convertase subtilisin/kexin type 6
PDLIM5 PDZ and LIM domain 5
PIGC phosphatidylinositol glycan anchor biosynthesis, class C
PLAU plasminogen activator, urokinase
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PRB1 proline-rich protein BstNI subfamily 1
PSAT1 phosphoserine aminotransferase 1
RARB retinoic acid receptor, beta
RCAN3 RCAN family member 3
RPGRIP1L RPGRIP1-like
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SCN10A sodium channel, voltage gated, type X alpha subunit
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
SFRP5 secreted frizzled-related protein 5
SIRT3 sirtuin 3
SIX1 SIX homeobox 1
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPN sialophorin
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
SREBF2 sterol regulatory element binding transcription factor 2
STAT5B signal transducer and activator of transcription 5B
SYNGR1 synaptogyrin 1
TBX3 T-box 3
TFPI2 tissue factor pathway inhibitor 2
TMEM151B transmembrane protein 151B
TMEM212 transmembrane protein 212
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TNK2 tyrosine kinase, non-receptor, 2
TOR4A torsin family 4, member A
TP53I11 tumor protein p53 inducible protein 11
TRIM3 tripartite motif containing 3
TTLL1 tubulin tyrosine ligase-like family member 1
VEGFA vascular endothelial growth factor A
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
AARSD1 alanyl-tRNA synthetase domain containing 1
ADGRG2 adhesion G protein-coupled receptor G2
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BCAS1 breast carcinoma amplified sequence 1
BCL9 B-cell CLL/lymphoma 9
C1QTNF3 C1q and tumor necrosis factor related protein 3
C6ORF47 chromosome 6 open reading frame 47
CENPO centromere protein O
CHKB choline kinase beta
CHML choroideremia-like (Rab escort protein 2)
CIR1 corepressor interacting with RBPJ, 1
CLCN5 chloride channel, voltage-sensitive 5
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
COL9A2 collagen, type IX, alpha 2
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DCLRE1A DNA cross-link repair 1A
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DGKE diacylglycerol kinase, epsilon 64kDa
DNAL4 dynein, axonemal, light chain 4
DOLPP1 dolichyldiphosphatase 1
EDC3 enhancer of mRNA decapping 3
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
ELMO3 engulfment and cell motility 3
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
EXOC5 exocyst complex component 5
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FOXRED2 FAD-dependent oxidoreductase domain containing 2
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GBP2 guanylate binding protein 2, interferon-inducible
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GTF2I general transcription factor IIi
INCENP inner centromere protein antigens 135/155kDa
INO80D INO80 complex subunit D
ITPKB inositol-trisphosphate 3-kinase B
KLF2 Kruppel-like factor 2
KLK5 kallikrein-related peptidase 5
KRT24 keratin 24, type I
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2
LRP2 low density lipoprotein receptor-related protein 2
LZTS3 leucine zipper, putative tumor suppressor family member 3
MANBA mannosidase, beta A, lysosomal
MAP3K6 mitogen-activated protein kinase kinase kinase 6
METTL16 methyltransferase like 16
MMP9 matrix metallopeptidase 9
MON1B MON1 secretory trafficking family member B
MTERF4 mitochondrial transcription termination factor 4
MUC3A mucin 3A, cell surface associated
MYO1D myosin ID
NBAS neuroblastoma amplified sequence
NHEJ1 nonhomologous end-joining factor 1
NIPAL2 NIPA-like domain containing 2
NPTX1 neuronal pentraxin I
NR1H3 nuclear receptor subfamily 1, group H, member 3
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6
ONECUT2 one cut homeobox 2
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PCSK7 proprotein convertase subtilisin/kexin type 7
PLEKHO1 pleckstrin homology domain containing, family O member 1
PLSCR4 phospholipid scramblase 4
PODXL2 podocalyxin-like 2
POLL polymerase (DNA directed), lambda
PRPH peripherin
PTDSS2 phosphatidylserine synthase 2
RAB36 RAB36, member RAS oncogene family
REM1 RAS (RAD and GEM)-like GTP-binding 1
RFTN1 raftlin, lipid raft linker 1
RNF43 ring finger protein 43
RPL23AP32 ribosomal protein L23a pseudogene 32
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SCN1B sodium channel, voltage gated, type I beta subunit
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SKI SKI proto-oncogene
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STIM1 stromal interaction molecule 1
STK16 serine/threonine kinase 16
TDP1 tyrosyl-DNA phosphodiesterase 1
TLR5 toll-like receptor 5
TM6SF1 transmembrane 6 superfamily member 1
TMED1 transmembrane emp24 protein transport domain containing 1
TMEM57 transmembrane protein 57
TP53I3 tumor protein p53 inducible protein 3
TRIM36 tripartite motif containing 36
TTC23 tetratricopeptide repeat domain 23
TUBA3C tubulin, alpha 3c
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene)
UPK3B uroplakin 3B
USB1 U6 snRNA biogenesis 1
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
ZC3H3 zinc finger CCCH-type containing 3
ZNF134 zinc finger protein 134
ZNF442 zinc finger protein 442
ZNF473 zinc finger protein 473
ZNF675 zinc finger protein 675