lobelanidine-1747 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the lobelanidine-1747 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCF2 ATP-binding cassette, sub-family F (GCN20), member 2
ABR active BCR-related
ADRBK2 adrenergic, beta, receptor kinase 2
AMBRA1 autophagy/beclin-1 regulator 1
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ATXN2 ataxin 2
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BCORL1 BCL6 corepressor-like 1
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CBX6 chromobox homolog 6
CCL23 chemokine (C-C motif) ligand 23
CDK5 cyclin-dependent kinase 5
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CLDN14 claudin 14
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
CRAT carnitine O-acetyltransferase
DCTN1 dynactin 1
DEAF1 DEAF1 transcription factor
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DZANK1 double zinc ribbon and ankyrin repeat domains 1
ECSIT ECSIT signalling integrator
EFHC2 EF-hand domain (C-terminal) containing 2
EHBP1L1 EH domain binding protein 1-like 1
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
FAM106A family with sequence similarity 106, member A
FANCF Fanconi anemia, complementation group F
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GEMIN4 gem (nuclear organelle) associated protein 4
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GK glycerol kinase
GLRX glutaredoxin (thioltransferase)
GPR1 G protein-coupled receptor 1
HIST1H4J histone cluster 1, H4j
HMCES 5-hydroxymethylcytosine (hmC) binding, ES cell-specific
HSDL2 hydroxysteroid dehydrogenase like 2
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
HTRA1 HtrA serine peptidase 1
HTT huntingtin
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IL18RAP interleukin 18 receptor accessory protein
KAT6B K(lysine) acetyltransferase 6B
KDM6A lysine (K)-specific demethylase 6A
KLHL21 kelch-like family member 21
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LBR lamin B receptor
MAP3K9 mitogen-activated protein kinase kinase kinase 9
MBD3 methyl-CpG binding domain protein 3
MCAM melanoma cell adhesion molecule
MED20 mediator complex subunit 20
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
MRC2 mannose receptor, C type 2
MTRF1L mitochondrial translational release factor 1-like
N4BP3 NEDD4 binding protein 3
NMRK2 nicotinamide riboside kinase 2
NOTCH2 notch 2
NPDC1 neural proliferation, differentiation and control, 1
NUCB1 nucleobindin 1
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2
OBSL1 obscurin-like 1
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PCGF2 polycomb group ring finger 2
PGC progastricsin (pepsinogen C)
PLCB2 phospholipase C, beta 2
PLIN2 perilipin 2
POLR2F polymerase (RNA) II (DNA directed) polypeptide F
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F
PRKD3 protein kinase D3
PTPRT protein tyrosine phosphatase, receptor type, T
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B)
RRN3P1 RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 1
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
SCAF4 SR-related CTD-associated factor 4
SEC14L4 SEC14-like 4 (S. cerevisiae)
SEC31B SEC31 homolog B (S. cerevisiae)
SH3GL3 SH3-domain GRB2-like 3
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC38A7 solute carrier family 38, member 7
SMAD3 SMAD family member 3
SOD3 superoxide dismutase 3, extracellular
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SYNGR1 synaptogyrin 1
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TCF3 transcription factor 3
TCTN1 tectonic family member 1
TMEM8A transmembrane protein 8A
TMPO thymopoietin
TTC3 tetratricopeptide repeat domain 3
UBE4B ubiquitination factor E4B
USF2 upstream transcription factor 2, c-fos interacting
VARS valyl-tRNA synthetase
WDR13 WD repeat domain 13
ZNF140 zinc finger protein 140
ZNF248 zinc finger protein 248
ZNF589 zinc finger protein 589
ZNHIT2 zinc finger, HIT-type containing 2

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ACP6 acid phosphatase 6, lysophosphatidic
ACTC1 actin, alpha, cardiac muscle 1
ACTN4 actinin, alpha 4
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
ANXA3 annexin A3
APOD apolipoprotein D
ARMC7 armadillo repeat containing 7
ASAP1-IT1 ASAP1 intronic transcript 1
ATAD2B ATPase family, AAA domain containing 2B
BAK1 BCL2-antagonist/killer 1
BANP BTG3 associated nuclear protein
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BCL7C B-cell CLL/lymphoma 7C
BRD9 bromodomain containing 9
BTK Bruton agammaglobulinemia tyrosine kinase
C19ORF54 chromosome 19 open reading frame 54
C1QTNF1 C1q and tumor necrosis factor related protein 1
C6ORF47 chromosome 6 open reading frame 47
CARD9 caspase recruitment domain family, member 9
CARM1 coactivator-associated arginine methyltransferase 1
CCNE1 cyclin E1
CD38 CD38 molecule
CD82 CD82 molecule
CDC73 cell division cycle 73
CDCA3 cell division cycle associated 3
CLCN6 chloride channel, voltage-sensitive 6
CRTAP cartilage associated protein
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
CTDNEP1 CTD nuclear envelope phosphatase 1
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal
DMBT1 deleted in malignant brain tumors 1
EGR2 early growth response 2
EPX eosinophil peroxidase
FAM188A family with sequence similarity 188, member A
FN3KRP fructosamine 3 kinase related protein
FTO fat mass and obesity associated
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GMIP GEM interacting protein
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GPHN gephyrin
GPRC5C G protein-coupled receptor, class C, group 5, member C
GPRC5D G protein-coupled receptor, class C, group 5, member D
GSS glutathione synthetase
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa
GTPBP6 GTP binding protein 6 (putative)
HCAR3 hydroxycarboxylic acid receptor 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
KCTD15 potassium channel tetramerization domain containing 15
KCTD3 potassium channel tetramerization domain containing 3
KIFC1 kinesin family member C1
LACTB2 lactamase, beta 2
LOC390998 ribosomal protein L10 pseudogene
MAGEF1 melanoma antigen family F1
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MAPK3 mitogen-activated protein kinase 3
MECR mitochondrial trans-2-enoyl-CoA reductase
MGAM maltase-glucoamylase
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MORC3 MORC family CW-type zinc finger 3
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MRPL19 mitochondrial ribosomal protein L19
NAT9 N-acetyltransferase 9 (GCN5-related, putative)
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae)
NOL6 nucleolar protein 6 (RNA-associated)
NT5DC3 5'-nucleotidase domain containing 3
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
PARG poly (ADP-ribose) glycohydrolase
PARM1 prostate androgen-regulated mucin-like protein 1
PES1 pescadillo ribosomal biogenesis factor 1
PHKG2 phosphorylase kinase, gamma 2 (testis)
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1
RAB8B RAB8B, member RAS oncogene family
SEC61G Sec61 gamma subunit
SH3GL1 SH3-domain GRB2-like 1
SKI SKI proto-oncogene
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2
SLMO2 slowmo homolog 2 (Drosophila)
SNX6 sorting nexin 6
STK39 serine threonine kinase 39
TFB2M transcription factor B2, mitochondrial
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TJP2 tight junction protein 2
TRHDE thyrotropin-releasing hormone degrading enzyme
TRPS1 trichorhinophalangeal syndrome I
TSPYL2 TSPY-like 2
TTBK2 tau tubulin kinase 2
UROS uroporphyrinogen III synthase
VGF VGF nerve growth factor inducible
WDR19 WD repeat domain 19
WDR37 WD repeat domain 37
WDR82 WD repeat domain 82
YEATS4 YEATS domain containing 4
ZC2HC1A zinc finger, C2HC-type containing 1A
ZIM2 zinc finger, imprinted 2
ZNF184 zinc finger protein 184
ZNF264 zinc finger protein 264