limb grasping Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description mice clasp front and/or hind feet almost immediately upon being lifted by tail (Mammalian Phenotype Ontology, MP_0001513)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0001513
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Genes

140 gene mutations causing the limb grasping phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AGRN agrin
AIRE autoimmune regulator
AKAP12 A kinase (PRKA) anchor protein 12
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ARAF A-Raf proto-oncogene, serine/threonine kinase
ATN1 atrophin 1
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2
ATXN1 ataxin 1
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CAMK4 calcium/calmodulin-dependent protein kinase IV
CAV1 caveolin 1, caveolae protein, 22kDa
CCND1 cyclin D1
CDH23 cadherin-related 23
CDKL5 cyclin-dependent kinase-like 5
CERS6 ceramide synthase 6
CHD7 chromodomain helicase DNA binding protein 7
CIB2 calcium and integrin binding family member 2
CLCN1 chloride channel, voltage-sensitive 1
CLN3 ceroid-lipofuscinosis, neuronal 3
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
COL12A1 collagen, type XII, alpha 1
CPLX2 complexin 2
CTNNA2 catenin (cadherin-associated protein), alpha 2
CTSF cathepsin F
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DBNL drebrin-like
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DMTF1 cyclin D binding myb-like transcription factor 1
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5
DOCK3 dedicator of cytokinesis 3
DPYSL5 dihydropyrimidinase-like 5
DST dystonin
DYSF dysferlin
ELAVL4 ELAV like neuron-specific RNA binding protein 4
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans)
EPHA4 EPH receptor A4
ERCC2 excision repair cross-complementation group 2
FBN2 fibrillin 2
FGF14 fibroblast growth factor 14
FKRP fukutin related protein
FOXB1 forkhead box B1
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2
GLB1 galactosidase, beta 1
GLRA1 glycine receptor, alpha 1
GLRB glycine receptor, beta
GRID2 glutamate receptor, ionotropic, delta 2
GRM1 glutamate receptor, metabotropic 1
GTF2IRD1 GTF2I repeat domain containing 1
HELT helt bHLH transcription factor
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
HEXB hexosaminidase B (beta polypeptide)
HIPK2 homeodomain interacting protein kinase 2
HOXB8 homeobox B8
HOXC8 homeobox C8
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA4 heat shock 70kDa protein 4
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HTRA2 HtrA serine peptidase 2
HTT huntingtin
IGHMBP2 immunoglobulin mu binding protein 2
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2
LAMA2 laminin, alpha 2
LAMA4 laminin, alpha 4
LAMC1 laminin, gamma 1 (formerly LAMB2)
LARGE like-glycosyltransferase
LPIN1 lipin 1
LRRC7 leucine rich repeat containing 7
LTN1 listerin E3 ubiquitin protein ligase 1
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MCOLN1 mucolipin 1
MECOM MDS1 and EVI1 complex locus
MECP2 methyl CpG binding protein 2
MEOX2 mesenchyme homeobox 2
MPZ myelin protein zero
MTMR2 myotubularin related protein 2
MYO7A myosin VIIA
NDFIP2 Nedd4 family interacting protein 2
NDRG1 N-myc downstream regulated 1
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)
NFIX nuclear factor I/X (CCAAT-binding transcription factor)
NGFR nerve growth factor receptor
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1
NIPBL Nipped-B homolog (Drosophila)
NPAS3 neuronal PAS domain protein 3
NPR2 natriuretic peptide receptor 2
NRD1 nardilysin (N-arginine dibasic convertase)
NTF3 neurotrophin 3
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
OPA1 optic atrophy 1 (autosomal dominant)
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PAX5 paired box 5
PEX2 peroxisomal biogenesis factor 2
PGAP3 post-GPI attachment to proteins 3
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PMP22 peripheral myelin protein 22
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPT1 palmitoyl-protein thioesterase 1
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PRX periaxin
PSAP prosaposin
PSIP1 PC4 and SFRS1 interacting protein 1
RAI1 retinoic acid induced 1
RND3 Rho family GTPase 3
RORA RAR-related orphan receptor A
RORB RAR-related orphan receptor B
RPE65 retinal pigment epithelium-specific protein 65kDa
SATB1 SATB homeobox 1
SBF2 SET binding factor 2
SCN4A sodium channel, voltage gated, type IV alpha subunit
SCN8A sodium channel, voltage gated, type VIII alpha subunit
SH3TC2 SH3 domain and tetratricopeptide repeats 2
SHANK2 SH3 and multiple ankyrin repeat domains 2
SHH sonic hedgehog
SIX1 SIX homeobox 1
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6
SLC6A5 solute carrier family 6 (neurotransmitter transporter), member 5
SPG20 spastic paraplegia 20 (Troyer syndrome)
SPTBN4 spectrin, beta, non-erythrocytic 4
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
STAMBP STAM binding protein
STRBP spermatid perinuclear RNA binding protein
SUMF1 sulfatase modifying factor 1
TARDBP TAR DNA binding protein
TP53COR1 tumor protein p53 pathway corepressor 1 (non-protein coding)
TRIB2 tribbles pseudokinase 2
TRPC3 transient receptor potential cation channel, subfamily C, member 3
TRPM7 transient receptor potential cation channel, subfamily M, member 7
UBE3A ubiquitin protein ligase E3A
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
VEGFA vascular endothelial growth factor A
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae)
WNT7A wingless-type MMTV integration site family, member 7A