lewy body Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description Cytoplasmic, spherical inclusion commonly found in damaged neurons, and composed of abnormally phosphorylated, neurofilament proteins aggregated with ubiquitin and alpha-synuclein. (Gene Ontology, GO_0097413)
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Genes

208 proteins co-occuring with the lewy body cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
TARDBP TAR DNA binding protein 1.89593
SNCAIP synuclein, alpha interacting protein 1.7432
FUS FUS RNA binding protein 1.65633
IGKV1-17 immunoglobulin kappa variable 1-17 1.22672
MYH9 myosin, heavy chain 9, non-muscle 1.18184
LRRK2 leucine-rich repeat kinase 2 1.14443
HTT huntingtin 1.09594
C9ORF72 chromosome 9 open reading frame 72 1.05337
CRYAB crystallin, alpha B 1.03228
SNCB synuclein, beta 1.01387
ATXN2 ataxin 2 0.991225
RBM45 RNA binding motif protein 45 0.954005
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.940215
SLC30A6 solute carrier family 30 (zinc transporter), member 6 0.797436
ACPP acid phosphatase, prostate 0.78004
UBQLN2 ubiquilin 2 0.764527
SNCG synuclein, gamma (breast cancer-specific protein 1) 0.717236
HEXA hexosaminidase A (alpha polypeptide) 0.703949
SIGMAR1 sigma non-opioid intracellular receptor 1 0.697344
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 0.692516
RAB9B RAB9B, member RAS oncogene family 0.689451
LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) 0.680719
CD79A CD79a molecule, immunoglobulin-associated alpha 0.6638
RRM2 ribonucleotide reductase M2 0.65345
TG thyroglobulin 0.650439
MAPT microtubule-associated protein tau 0.62393
HSPA4 heat shock 70kDa protein 4 0.620529
IFNA8 interferon, alpha 8 0.598538
PPBPP1 pro-platelet basic protein pseudogene 1 0.584686
TPPP tubulin polymerization promoting protein 0.579251
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.567169
PABPN1 poly(A) binding protein, nuclear 1 0.567169
SQSTM1 sequestosome 1 0.565923
GRN granulin 0.529208
ATXN3 ataxin 3 0.521432
TTC39A tetratricopeptide repeat domain 39A 0.5149
SOD1 superoxide dismutase 1, soluble 0.514085
IFNE interferon, epsilon 0.503506
ENO2 enolase 2 (gamma, neuronal) 0.495395
KRT8 keratin 8, type II 0.491348
GFAP glial fibrillary acidic protein 0.480453
APOE apolipoprotein E 0.469604
FAM65B family with sequence similarity 65, member B 0.4676
NTNG1 netrin G1 0.4672
PFN3 profilin 3 0.465998
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.459602
TH tyrosine hydroxylase 0.455613
PRMT1 protein arginine methyltransferase 1 0.453223
PRMT8 protein arginine methyltransferase 8 0.445672
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.443292
RRM1 ribonucleotide reductase M1 0.438542
ABLIM1 actin binding LIM protein 1 0.435775
MAGEC1 melanoma antigen family C1 0.434591
PABPC1 poly(A) binding protein, cytoplasmic 1 0.433801
PFDN5 prefoldin subunit 5 0.409089
HAP1 huntingtin-associated protein 1 0.408309
HELT helt bHLH transcription factor 0.407919
MAP3K10 mitogen-activated protein kinase kinase kinase 10 0.404415
CHMP2B charged multivesicular body protein 2B 0.402859
TFE3 transcription factor binding to IGHM enhancer 3 0.400527
SEPT4 septin 4 0.400139
DAZAP1 DAZ associated protein 1 0.394323
SYP synaptophysin 0.392775
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.387751
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.377738
CD68 CD68 molecule 0.377354
OPTC opticin 0.373899
GYS1 glycogen synthase 1 (muscle) 0.364713
CALCA calcitonin-related polypeptide alpha 0.363949
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor 0.361659
IDUA iduronidase, alpha-L- 0.356705
LYZ lysozyme 0.355563
NTNG2 netrin G2 0.354422
PARK2 parkin RBR E3 ubiquitin protein ligase 0.350243
ACRBP acrosin binding protein 0.344935
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 0.338128
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 0.332848
TP53INP1 tumor protein p53 inducible nuclear protein 1 0.325702
BAG3 BCL2-associated athanogene 3 0.321575
PSEN1 presenilin 1 0.319328
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.315586
EIF3K eukaryotic translation initiation factor 3, subunit K 0.314839
KRT18 keratin 18, type I 0.309986
ARSB arylsulfatase B 0.308867
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) 0.304771
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 0.303655
MLANA melan-A 0.298826
MYO5B myosin VB 0.297342
MSI1 musashi RNA-binding protein 1 0.29623
BCHE butyrylcholinesterase 0.294007
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.292157
ALG1 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase 0.285507
B3GAT1 beta-1,3-glucuronyltransferase 1 0.280349
POMC proopiomelanocortin 0.27998
LAD1 ladinin 1 0.278877
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.277774
LRSAM1 leucine rich repeat and sterile alpha motif containing 1 0.277038
PHF1 PHD finger protein 1 0.276304
ARSE arylsulfatase E (chondrodysplasia punctata 1) 0.275936
LINGO1 leucine rich repeat and Ig domain containing 1 0.273367
SETX senataxin 0.273367
CLU clusterin 0.273122
VAC14 Vac14 homolog (S. cerevisiae) 0.267139
KRT7 keratin 7, type II 0.265677
HSH2D hematopoietic SH2 domain containing 0.254017
ARSD arylsulfatase D 0.251114
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 0.250389
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.246046
UBC ubiquitin C 0.244962
ALPPL2 alkaline phosphatase, placental-like 2 0.24424
ALPL alkaline phosphatase, liver/bone/kidney 0.243879
PAX8 paired box 8 0.243879
ALPP alkaline phosphatase, placental 0.243519
ELOVL4 ELOVL fatty acid elongase 4 0.239557
MYOT myotilin 0.239197
PRMT3 protein arginine methyltransferase 3 0.238119
BCOR BCL6 corepressor 0.238119
NKX2-1 NK2 homeobox 1 0.23776
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.234533
PLIN4 perilipin 4 0.229532
SPA17 sperm autoantigenic protein 17 0.226331
STXBP2 syntaxin binding protein 2 0.224558
RPS27A ribosomal protein S27a 0.223497
VCP valosin containing protein 0.223497
SOD2 superoxide dismutase 2, mitochondrial 0.22279
AR androgen receptor 0.22173
RPE65 retinal pigment epithelium-specific protein 65kDa 0.22173
CPB1 carboxypeptidase B1 (tissue) 0.215412
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4 0.215063
SEPT8 septin 8 0.214714
LXN latexin 0.214366
MPO myeloperoxidase 0.209858
UBB ubiquitin B 0.209513
TOR1A torsin family 1, member A (torsin A) 0.206766
AGA aspartylglucosaminidase 0.203699
UBE2H ubiquitin-conjugating enzyme E2H 0.203361
NASP nuclear autoantigenic sperm protein (histone-binding) 0.203022
CDK5 cyclin-dependent kinase 5 0.202346
DDX19B DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B 0.200663
STAT5B signal transducer and activator of transcription 5B 0.200328
UBA2 ubiquitin-like modifier activating enzyme 2 0.199659
DGKZ diacylglycerol kinase, zeta 0.198658
CYP4V2 cytochrome P450, family 4, subfamily V, polypeptide 2 0.193719
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.192746
PLIN5 perilipin 5 0.1921
ANG angiogenin, ribonuclease, RNase A family, 5 0.190495
GALE UDP-galactose-4-epimerase 0.189222
MB myoglobin 0.187646
TARS threonyl-tRNA synthetase 0.186087
ITCH itchy E3 ubiquitin protein ligase 0.180339
MT3 metallothionein 3 0.180045
PTPRC protein tyrosine phosphatase, receptor type, C 0.179752
AFP alpha-fetoprotein 0.177724
STRN striatin, calmodulin binding protein 0.177439
TP73 tumor protein p73 0.17687
PML promyelocytic leukemia 0.176024
TBX3 T-box 3 0.175745
HTRA2 HtrA serine peptidase 2 0.175188
DMD dystrophin 0.173814
SEPT5 septin 5 0.172468
MASP2 mannan-binding lectin serine peptidase 2 0.17141
NOP56 NOP56 ribonucleoprotein 0.171149
CSNK2A1 casein kinase 2, alpha 1 polypeptide 0.170629
FLNC filamin C, gamma 0.169859
LDB3 LIM domain binding 3 0.16935
IFITM2 interferon induced transmembrane protein 2 0.169099
MAL mal, T-cell differentiation protein 0.168598
RBL2 retinoblastoma-like 2 0.167856
EWSR1 EWS RNA-binding protein 1 0.166884
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 0.165463
OGN osteoglycin 0.16477
IGHV3-30 immunoglobulin heavy variable 3-30 0.164315
NEFM neurofilament, medium polypeptide 0.164315
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 0.16342
DEDD death effector domain containing 0.162546
TXNL1 thioredoxin-like 1 0.161693
CALB2 calbindin 2 0.160863
FMR1 fragile X mental retardation 1 0.158882
ARSH arylsulfatase family, member H 0.158882
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 0.157218
TIA1 TIA1 cytotoxic granule-associated RNA binding protein 0.156863
LIPA lipase A, lysosomal acid, cholesterol esterase 0.156688
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin) 0.156513
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 0.144994
RTN4R reticulon 4 receptor 0.144438
TGOLN2 trans-golgi network protein 2 0.141382
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 0.140205
GBA glucosidase, beta, acid 0.139265
GRIA2 glutamate receptor, ionotropic, AMPA 2 0.137551
APP amyloid beta (A4) precursor protein 0.136839
RAB11A RAB11A, member RAS oncogene family 0.136711
COMT catechol-O-methyltransferase 0.136307
PSEN2 presenilin 2 0.136119
MCF2 MCF.2 cell line derived transforming sequence 0.135787
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae) 0.135589
PVALB parvalbumin 0.135533
GSTP1 glutathione S-transferase pi 1 0.13504
DRD2 dopamine receptor D2 0.133976
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa 0.133779
AIF1 allograft inflammatory factor 1 0.13279
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 0.132001
MAOB monoamine oxidase B 0.131875
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 0.131859
MAP1B microtubule-associated protein 1B 0.131167
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.130769
EGFR epidermal growth factor receptor 0.129041
NPC2 Niemann-Pick disease, type C2 0.128344
APAF1 apoptotic peptidase activating factor 1 0.128146