lewy body dementia Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A dementia and a synucleinopathy that is characterized by the development of abnormal proteinaceous (alpha-synuclein) cytoplasmic inclusions, called Lewy bodies, throughout the brain that results in progressive decline in mental abilities. (Human Disease Ontology, DOID_12217)
Similar Terms
Downloads & Tools

Genes

189 genes co-occuring with the disease lewy body dementia in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
BCHE butyrylcholinesterase 2.27375
SNCB synuclein, beta 1.94031
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2 1.73413
SNCA synuclein, alpha (non A4 component of amyloid precursor) 1.72365
IGKV1-17 immunoglobulin kappa variable 1-17 1.62649
MAPT microtubule-associated protein tau 1.62515
LRRK2 leucine-rich repeat kinase 2 1.58448
SNCAIP synuclein, alpha interacting protein 1.58091
ACHE acetylcholinesterase (Yt blood group) 1.58046
APOE apolipoprotein E 1.56844
SNCG synuclein, gamma (breast cancer-specific protein 1) 1.52424
GBA glucosidase, beta, acid 1.34068
TH tyrosine hydroxylase 1.28566
C5ORF49 chromosome 5 open reading frame 49 1.25645
TPPP tubulin polymerization promoting protein 1.21782
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa 1.19273
CHAT choline O-acetyltransferase 1.16521
GRN granulin 1.09839
UBB ubiquitin B 1.08537
UBC ubiquitin C 1.07068
RPS27A ribosomal protein S27a 1.0606
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 1.01891
CHMP2B charged multivesicular body protein 2B 1.01216
SYP synaptophysin 1.00246
ATP13A2 ATPase type 13A2 0.996127
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 0.988957
PSEN1 presenilin 1 0.966663
KCNMB2 potassium channel subfamily M regulatory beta subunit 2 0.964986
TARDBP TAR DNA binding protein 0.915139
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 0.910199
CBS cystathionine-beta-synthase 0.908142
PARK2 parkin RBR E3 ubiquitin protein ligase 0.901156
TRIM9 tripartite motif containing 9 0.879833
C9ORF72 chromosome 9 open reading frame 72 0.861818
KLK6 kallikrein-related peptidase 6 0.861818
HCRT hypocretin (orexin) neuropeptide precursor 0.85404
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.788442
SYNC syncoilin, intermediate filament protein 0.770435
FUS FUS RNA binding protein 0.767576
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha 0.756971
PLK2 polo-like kinase 2 0.735838
C11ORF58 chromosome 11 open reading frame 58 0.726524
PRNP prion protein 0.722886
TMEM106B transmembrane protein 106B 0.710378
HSPA4 heat shock 70kDa protein 4 0.706754
ZRANB2 zinc finger, RAN-binding domain containing 2 0.699116
ZCWPW1 zinc finger, CW type with PWWP domain 1 0.671527
PSEN2 presenilin 2 0.66199
SEPT8 septin 8 0.650903
RPH3A rabphilin 3A 0.648533
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase 0.647743
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 0.647743
UBQLN2 ubiquilin 2 0.610838
MAP1B microtubule-associated protein 1B 0.6003
CRYAB crystallin, alpha B 0.596402
ATG10 autophagy related 10 0.589779
RAB5B RAB5B, member RAS oncogene family 0.583941
CSNK1D casein kinase 1, delta 0.58005
CYP2D7 cytochrome P450, family 2, subfamily D, polypeptide 7 (gene/pseudogene) 0.574217
MAOA monoamine oxidase A 0.570718
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 0.561004
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) 0.560616
PORCN porcupine homolog (Drosophila) 0.560227
HTRA2 HtrA serine peptidase 2 0.556732
MAOB monoamine oxidase B 0.553627
EIF3E eukaryotic translation initiation factor 3, subunit E 0.548583
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 0.545093
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.535022
SGSH N-sulfoglucosamine sulfohydrolase 0.533088
UBE2S ubiquitin-conjugating enzyme E2S 0.531154
LAMP2 lysosomal-associated membrane protein 2 0.519961
SLC17A3 solute carrier family 17 (organic anion transporter), member 3 0.519575
FUBP1 far upstream element (FUSE) binding protein 1 0.517649
GEN1 GEN1 Holliday junction 5' flap endonuclease 0.513417
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.509959
CLSTN1 calsyntenin 1 0.506507
CA13 carbonic anhydrase XIII 0.505739
SAMD9 sterile alpha motif domain containing 9 0.503824
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 0.497321
KRT31 keratin 31, type I 0.496939
VCP valosin containing protein 0.494648
UBE2K ubiquitin-conjugating enzyme E2K 0.488549
COMT catechol-O-methyltransferase 0.484364
APP amyloid beta (A4) precursor protein 0.480945
CASS4 Cas scaffolding protein family member 4 0.47753
BDNF brain-derived neurotrophic factor 0.474498
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.474119
CTSD cathepsin D 0.473361
MAP4 microtubule-associated protein 4 0.457109
ADRBK1 adrenergic, beta, receptor kinase 1 0.455978
SEPW1 selenoprotein W, 1 0.455224
CA1 carbonic anhydrase I 0.454847
PVALB parvalbumin 0.450324
MAP1A microtubule-associated protein 1A 0.448441
SPAG9 sperm associated antigen 9 0.436402
HTT huntingtin 0.435651
SEPT5 septin 5 0.434524
STX6 syntaxin 6 0.431894
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 0.430017
MCF2 MCF.2 cell line derived transforming sequence 0.42814
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) 0.42589
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A 0.425514
MOBP myelin-associated oligodendrocyte basic protein 0.418768
HSPA8 heat shock 70kDa protein 8 0.415773
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.411283
PINK1 PTEN induced putative kinase 1 0.405678
SOD2 superoxide dismutase 2, mitochondrial 0.403064
PRDX6 peroxiredoxin 6 0.402318
SEPT7 septin 7 0.398962
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like 0.398962
RTN3 reticulon 3 0.396725
PREP prolyl endopeptidase 0.395235
FABP3 fatty acid binding protein 3, muscle and heart 0.393746
HIST1H1C histone cluster 1, H1c 0.386308
VSNL1 visinin-like 1 0.383337
A2M alpha-2-macroglobulin 0.38111
TPH1 tryptophan hydroxylase 1 0.378885
PLK3 polo-like kinase 3 0.364454
SEPT6 septin 6 0.362978
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 0.356341
CA4 carbonic anhydrase IV 0.354499
UBE2H ubiquitin-conjugating enzyme E2H 0.350452
RAB5A RAB5A, member RAS oncogene family 0.345308
COQ2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase 0.344207
MAP2 microtubule-associated protein 2 0.33944
CDR1 cerebellar degeneration-related protein 1, 34kDa 0.338341
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) 0.332487
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 0.332121
UBE2D2 ubiquitin-conjugating enzyme E2D 2 0.329565
AFF1 AF4/FMR2 family, member 1 0.325552
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.325552
DRD2 dopamine receptor D2 0.32373
HDAC6 histone deacetylase 6 0.317545
PRND prion protein 2 (dublet) 0.315003
USP1 ubiquitin specific peptidase 1 0.312102
NBPF1 neuroblastoma breakpoint family, member 1 0.303781
ADRA2C adrenoceptor alpha 2C 0.30342
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 0.302698
CSTB cystatin B (stefin B) 0.295851
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.295492
KCNC1 potassium channel, voltage gated Shaw related subfamily C, member 1 0.29118
ADAM22 ADAM metallopeptidase domain 22 0.289027
FIG4 FIG4 phosphoinositide 5-phosphatase 0.286877
IREB2 iron-responsive element binding protein 2 0.284728
RASD1 RAS, dexamethasone-induced 1 0.283655
PARK7 parkinson protein 7 0.281868
DPP7 dipeptidyl-peptidase 7 0.28151
CA2 carbonic anhydrase II 0.274021
S100B S100 calcium binding protein B 0.273664
KIAA0101 KIAA0101 0.273308
PLD1 phospholipase D1, phosphatidylcholine-specific 0.27153
COPS2 COP9 signalosome subunit 2 0.265849
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.264785
FTL ferritin, light polypeptide 0.258417
FTH1 ferritin, heavy polypeptide 1 0.258064
CST3 cystatin C 0.256652
USP9X ubiquitin specific peptidase 9, X-linked 0.253127
BECN1 beclin 1, autophagy related 0.250311
SQSTM1 sequestosome 1 0.241895
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 0.241196
GCH1 GTP cyclohydrolase 1 0.236312
RAB3A RAB3A, member RAS oncogene family 0.22937
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.226952
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) 0.223853
MANBA mannosidase, beta A, lysosomal 0.223165
ATG5 autophagy related 5 0.222822
SPG11 spastic paraplegia 11 (autosomal recessive) 0.222136
BAX BCL2-associated X protein 0.213621
GSK3B glycogen synthase kinase 3 beta 0.208579
DBN1 drebrin 1 0.206913
CLIP1 CAP-GLY domain containing linker protein 1 0.203933
OPTN optineurin 0.200656
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.195183
GRM5 glutamate receptor, metabotropic 5 0.194865
OR4F29 olfactory receptor, family 4, subfamily F, member 29 0.194548
SIAH1 siah E3 ubiquitin protein ligase 1 0.185313
YIPF1 Yip1 domain family, member 1 0.18472
MIR96 microRNA 96 0.182957
ATG12 autophagy related 12 0.17952
SEPT4 septin 4 0.17896
CLU clusterin 0.175411
PCNT pericentrin 0.174881
CAT catalase 0.174617
GABARAP GABA(A) receptor-associated protein 0.173314
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 0.170299
ENO2 enolase 2 (gamma, neuronal) 0.169571
AIF1 allograft inflammatory factor 1 0.162505
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4 0.161331
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.157929