levcycloserine-4524 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the levcycloserine-4524 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A2M alpha-2-macroglobulin
ACRV1 acrosomal vesicle protein 1
ADARB1 adenosine deaminase, RNA-specific, B1
AFF4 AF4/FMR2 family, member 4
ASPN asporin
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C10ORF12 chromosome 10 open reading frame 12
C5AR1 complement component 5a receptor 1
C8A complement component 8, alpha polypeptide
CCDC186 coiled-coil domain containing 186
CCL5 chemokine (C-C motif) ligand 5
CD3D CD3d molecule, delta (CD3-TCR complex)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CENPO centromere protein O
CFHR2 complement factor H-related 2
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
COL1A1 collagen, type I, alpha 1
CST1 cystatin SN
CTNND2 catenin (cadherin-associated protein), delta 2
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYTH1 cytohesin 1
DIAPH2-AS1 DIAPH2 antisense RNA 1
DVL3 dishevelled segment polarity protein 3
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
FBXO22 F-box protein 22
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FLT3LG fms-related tyrosine kinase 3 ligand
FLT4 fms-related tyrosine kinase 4
GATA3 GATA binding protein 3
GLRA1 glycine receptor, alpha 1
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GPC3 glypican 3
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
GPR19 G protein-coupled receptor 19
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HOXB1 homeobox B1
HOXC5 homeobox C5
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
IDI2-AS1 IDI2 antisense RNA 1
IL1RN interleukin 1 receptor antagonist
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITM2A integral membrane protein 2A
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KIF5C kinesin family member 5C
KRTAP5-9 keratin associated protein 5-9
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LOC100286895 cell division cycle 27 homolog pseudogene
LOXL2 lysyl oxidase-like 2
LRRTM2 leucine rich repeat transmembrane neuronal 2
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
MAGOH2P mago-nashi homolog 2, pseudogene
MCOLN3 mucolipin 3
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MUC8 mucin 8
MYL10 myosin, light chain 10, regulatory
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa
NEURL1 neuralized E3 ubiquitin protein ligase 1
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin)
NRP1 neuropilin 1
OCA2 oculocutaneous albinism II
PDE11A phosphodiesterase 11A
PLEKHS1 pleckstrin homology domain containing, family S member 1
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
PRKCA protein kinase C, alpha
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RABGAP1L RAB GTPase activating protein 1-like
RGS7 regulator of G-protein signaling 7
RNF126P1 ring finger protein 126 pseudogene 1
RUNX1 runt-related transcription factor 1
SCAND2P SCAN domain containing 2 pseudogene
SGK2 serum/glucocorticoid regulated kinase 2
SPAG8 sperm associated antigen 8
SPTBN5 spectrin, beta, non-erythrocytic 5
SSX1 synovial sarcoma, X breakpoint 1
STK17B serine/threonine kinase 17b
SUSD5 sushi domain containing 5
TCP10 t-complex 10
TECTA tectorin alpha
THOC5 THO complex 5
TMPRSS2 transmembrane protease, serine 2
TRIM10 tripartite motif containing 10
TTC39A tetratricopeptide repeat domain 39A
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
UNC93A unc-93 homolog A (C. elegans)
VIPR2 vasoactive intestinal peptide receptor 2
ZNF334 zinc finger protein 334
ZNF391 zinc finger protein 391
ZNF518A zinc finger protein 518A
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ABHD8 abhydrolase domain containing 8
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ACIN1 apoptotic chromatin condensation inducer 1
ACSL4 acyl-CoA synthetase long-chain family member 4
ANKRD40 ankyrin repeat domain 40
APOL6 apolipoprotein L, 6
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ASPHD1 aspartate beta-hydroxylase domain containing 1
BAHD1 bromo adjacent homology domain containing 1
C11ORF30 chromosome 11 open reading frame 30
C5ORF45 chromosome 5 open reading frame 45
CA5BP1 carbonic anhydrase VB pseudogene 1
CDH7 cadherin 7, type 2
CENPT centromere protein T
CHMP7 charged multivesicular body protein 7
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
DCUN1D2 DCN1, defective in cullin neddylation 1, domain containing 2
DDIT4 DNA-damage-inducible transcript 4
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13
EFNA3 ephrin-A3
EN2 engrailed homeobox 2
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
EPHA4 EPH receptor A4
FBXL6 F-box and leucine-rich repeat protein 6
FHOD1 formin homology 2 domain containing 1
FOXK2 forkhead box K2
FSTL3 follistatin-like 3 (secreted glycoprotein)
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GPX2 glutathione peroxidase 2
GUSBP3 glucuronidase, beta pseudogene 3
HDAC7 histone deacetylase 7
HIRA histone cell cycle regulator
HIST1H2BO histone cluster 1, H2bo
HIST1H3G histone cluster 1, H3g
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
LIN7B lin-7 homolog B (C. elegans)
LRRK1 leucine-rich repeat kinase 1
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MAST3 microtubule associated serine/threonine kinase 3
MCC mutated in colorectal cancers
MEIS1 Meis homeobox 1
MFSD11 major facilitator superfamily domain containing 11
MON1B MON1 secretory trafficking family member B
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MRPL28 mitochondrial ribosomal protein L28
MTA2 metastasis associated 1 family, member 2
MYH15 myosin, heavy chain 15
NDRG1 N-myc downstream regulated 1
NDRG4 NDRG family member 4
NOTCH1 notch 1
NR1H3 nuclear receptor subfamily 1, group H, member 3
NRSN2 neurensin 2
NT5DC3 5'-nucleotidase domain containing 3
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1
PHACTR4 phosphatase and actin regulator 4
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKX protein kinase, X-linked
PRR7 proline rich 7 (synaptic)
RABL6 RAB, member RAS oncogene family-like 6
RFWD3 ring finger and WD repeat domain 3
RGS17 regulator of G-protein signaling 17
RPH3AL rabphilin 3A-like (without C2 domains)
SEC14L2 SEC14-like 2 (S. cerevisiae)
SEPP1 selenoprotein P, plasma, 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SH3TC2 SH3 domain and tetratricopeptide repeats 2
SHARPIN SHANK-associated RH domain interactor
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
STAG3 stromal antigen 3
STARD3 StAR-related lipid transfer (START) domain containing 3
STK16 serine/threonine kinase 16
TBC1D8B TBC1 domain family, member 8B (with GRAM domain)
TEX40 testis expressed 40
THBS3 thrombospondin 3
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMEM132A transmembrane protein 132A
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TOR4A torsin family 4, member A
TRAIP TRAF interacting protein
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
VAT1 vesicle amine transport 1
WDR19 WD repeat domain 19
YPEL1 yippee-like 1 (Drosophila)
ZBTB22 zinc finger and BTB domain containing 22
ZFAND3 zinc finger, AN1-type domain 3
ZNF205 zinc finger protein 205
ZNF276 zinc finger protein 276
ZNF510 zinc finger protein 510
ZNF667 zinc finger protein 667
ZNF747 zinc finger protein 747
ZNF768 zinc finger protein 768