leukocyte tethering or rolling Gene Set

Dataset GO Biological Process Annotations
Category structural or functional annotations
Type biological process
Description Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels. Carbohydrates on circulating leukocytes bind selectins on the vessel wall causing the leukocytes to slow down and roll along the inner surface of the vessel wall. During this rolling motion, transitory bonds are formed and broken between selectins and their ligands. Typically the first step in cellular extravasation (the movement of leukocytes out of the circulatory system, towards the site of tissue damage or infection). (Gene Ontology, GO_0050901)
External Link http://amigo.geneontology.org/amigo/term/GO:0050901
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Genes

15 genes participating in the leukocyte tethering or rolling biological process from the curated GO Biological Process Annotations dataset.

Symbol Name
CHST4 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GOLPH3 golgi phosphoprotein 3 (coat-protein)
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB7 integrin, beta 7
LEP leptin
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
PODXL2 podocalyxin-like 2
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
SELE selectin E
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SELPLG selectin P ligand
TNF tumor necrosis factor
VCAM1 vascular cell adhesion molecule 1