leukocyte activation Gene Set

Dataset GO Biological Process Annotations
Category structural or functional annotations
Type biological process
Description A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor. (Gene Ontology, GO_0045321)
External Link http://amigo.geneontology.org/amigo/term/GO:0045321
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Genes

377 genes participating in the leukocyte activation biological process from the curated GO Biological Process Annotations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ACKR2 atypical chemokine receptor 2
ADA adenosine deaminase
ADAM10 ADAM metallopeptidase domain 10
ADAM17 ADAM metallopeptidase domain 17
ADAM9 ADAM metallopeptidase domain 9
AICDA activation-induced cytidine deaminase
AIF1 allograft inflammatory factor 1
AKAP17A A kinase (PRKA) anchor protein 17A
AMICA1 adhesion molecule, interacts with CXADR antigen 1
ANXA1 annexin A1
ANXA3 annexin A3
APC adenomatous polyposis coli
ATP11C ATPase, class VI, type 11C
ATP7A ATPase, Cu++ transporting, alpha polypeptide
AXL AXL receptor tyrosine kinase
AZI2 5-azacytidine induced 2
AZU1 azurocidin 1
B2M beta-2-microglobulin
BANK1 B-cell scaffold protein with ankyrin repeats 1
BATF basic leucine zipper transcription factor, ATF-like
BATF2 basic leucine zipper transcription factor, ATF-like 2
BATF3 basic leucine zipper transcription factor, ATF-like 3
BAX BCL2-associated X protein
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCL2 B-cell CLL/lymphoma 2
BCL3 B-cell CLL/lymphoma 3
BCL6 B-cell CLL/lymphoma 6
BLK BLK proto-oncogene, Src family tyrosine kinase
BLM Bloom syndrome, RecQ helicase-like
BLNK B-cell linker
BRAF B-Raf proto-oncogene, serine/threonine kinase
BST2 bone marrow stromal cell antigen 2
BTK Bruton agammaglobulinemia tyrosine kinase
BTN3A1 butyrophilin, subfamily 3, member A1
CADM1 cell adhesion molecule 1
CAMK4 calcium/calmodulin-dependent protein kinase IV
CASP8 caspase 8, apoptosis-related cysteine peptidase
CBFB core-binding factor, beta subunit
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL3 chemokine (C-C motif) ligand 3
CCL5 chemokine (C-C motif) ligand 5
CCND3 cyclin D3
CD151 CD151 molecule (Raph blood group)
CD180 CD180 molecule
CD1C CD1c molecule
CD2 CD2 molecule
CD276 CD276 molecule
CD28 CD28 molecule
CD3D CD3d molecule, delta (CD3-TCR complex)
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD3G CD3g molecule, gamma (CD3-TCR complex)
CD4 CD4 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CD7 CD7 molecule
CD79A CD79a molecule, immunoglobulin-associated alpha
CD80 CD80 molecule
CD86 CD86 molecule
CD8A CD8a molecule
CD8B CD8b molecule
CD93 CD93 molecule
CDK6 cyclin-dependent kinase 6
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHD7 chromodomain helicase DNA binding protein 7
CHGA chromogranin A
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CLCF1 cardiotrophin-like cytokine factor 1
CLEC4F C-type lectin domain family 4, member F
CLEC7A C-type lectin domain family 7, member A
CLU clusterin
CMTM7 CKLF-like MARVEL transmembrane domain containing 7
CPLX2 complexin 2
CR2 complement component (3d/Epstein Barr virus) receptor 2
CRIP3 cysteine-rich protein 3
CRTAM cytotoxic and regulatory T cell molecule
CRTC3 CREB regulated transcription coactivator 3
CSF1 colony stimulating factor 1 (macrophage)
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTPS1 CTP synthase 1
CX3CL1 chemokine (C-X3-C motif) ligand 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXADR coxsackie virus and adenovirus receptor
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR2 chemokine (C-X-C motif) receptor 2
CXCR4 chemokine (C-X-C motif) receptor 4
CXCR5 chemokine (C-X-C motif) receptor 5
DCLRE1C DNA cross-link repair 1C
DCSTAMP dendrocyte expressed seven transmembrane protein
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLG1 discs, large homolog 1 (Drosophila)
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DOCK2 dedicator of cytokinesis 2
DOCK8 dedicator of cytokinesis 8
DPP4 dipeptidyl-peptidase 4
EDN1 endothelin 1
EDN2 endothelin 2
EGR1 early growth response 1
ELF4 E74-like factor 4 (ets domain transcription factor)
EOMES eomesodermin
ERCC1 excision repair cross-complementation group 1
EXO1 exonuclease 1
EXOSC3 exosome component 3
EXOSC6 exosome component 6
F2RL1 coagulation factor II (thrombin) receptor-like 1
FADD Fas (TNFRSF6)-associated via death domain
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FKBP1A FK506 binding protein 1A, 12kDa
FKBP1B FK506 binding protein 1B, 12.6 kDa
FLT3 fms-related tyrosine kinase 3
FLT3LG fms-related tyrosine kinase 3 ligand
FNIP1 folliculin interacting protein 1
FOXP1 forkhead box P1
FOXP3 forkhead box P3
FUT7 fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
FYN FYN proto-oncogene, Src family tyrosine kinase
FZD5 frizzled class receptor 5
FZD7 frizzled class receptor 7
FZD8 frizzled class receptor 8
FZD9 frizzled class receptor 9
GAPT GRB2-binding adaptor protein, transmembrane
GATA3 GATA binding protein 3
GIMAP1 GTPase, IMAP family member 1
GLI3 GLI family zinc finger 3
GPR183 G protein-coupled receptor 183
HDAC4 histone deacetylase 4
HDAC5 histone deacetylase 5
HDAC9 histone deacetylase 9
HELLS helicase, lymphoid-specific
HHEX hematopoietically expressed homeobox
HLA-E major histocompatibility complex, class I, E
HMGB1 high mobility group box 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSH2D hematopoietic SH2 domain containing
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HYAL2 hyaluronoglucosaminidase 2
ICAM1 intercellular adhesion molecule 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFNA10 interferon, alpha 10
IFNA14 interferon, alpha 14
IFNA16 interferon, alpha 16
IFNA17 interferon, alpha 17
IFNA21 interferon, alpha 21
IFNA4 interferon, alpha 4
IFNA5 interferon, alpha 5
IFNA6 interferon, alpha 6
IFNA7 interferon, alpha 7
IFNA8 interferon, alpha 8
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNB1 interferon, beta 1, fibroblast
IFNE interferon, epsilon
IFNG interferon, gamma
IFNK interferon, kappa
IFNW1 interferon, omega 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IKZF3 IKAROS family zinc finger 3 (Aiolos)
IL10 interleukin 10
IL11 interleukin 11
IL12B interleukin 12B
IL13 interleukin 13
IL15 interleukin 15
IL18 interleukin 18
IL18R1 interleukin 18 receptor 1
IL2 interleukin 2
IL21R interleukin 21 receptor
IL23A interleukin 23, alpha subunit p19
IL4 interleukin 4
IL7R interleukin 7 receptor
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INS insulin
IRF1 interferon regulatory factor 1
IRF4 interferon regulatory factor 4
ITFG2 integrin alpha FG-GAP repeat containing 2
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGAD integrin, alpha D
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITK IL2-inducible T-cell kinase
JAG2 jagged 2
JAK3 Janus kinase 3
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KIF13B kinesin family member 13B
KIR3DS1 killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLF6 Kruppel-like factor 6
KLRF2 killer cell lectin-like receptor subfamily F, member 2
KMT2E lysine (K)-specific methyltransferase 2E
LAT linker for activation of T cells
LAT2 linker for activation of T cells family, member 2
LAX1 lymphocyte transmembrane adaptor 1
LBP lipopolysaccharide binding protein
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LEF1 lymphoid enhancer-binding factor 1
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS8 lectin, galactoside-binding, soluble, 8
LIG4 ligase IV, DNA, ATP-dependent
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
LRRC8A leucine rich repeat containing 8 family, member A
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
LY6D lymphocyte antigen 6 complex, locus D
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MALT1 MALT1 paracaspase
MEF2C myocyte enhancer factor 2C
MERTK MER proto-oncogene, tyrosine kinase
MICA MHC class I polypeptide-related sequence A
MICB MHC class I polypeptide-related sequence B
MILR1 mast cell immunoglobulin-like receptor 1
MLH1 mutL homolog 1
MPZL2 myelin protein zero-like 2
MRGPRX2 MAS-related GPR, member X2
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MSH2 mutS homolog 2
MSH6 mutS homolog 6
MT1G metallothionein 1G
MYB v-myb avian myeloblastosis viral oncogene homolog
MYO1F myosin IF
NBN nibrin
NCK1 NCK adaptor protein 1
NCK2 NCK adaptor protein 2
NCOR1 nuclear receptor corepressor 1
NCR1 natural cytotoxicity triggering receptor 1
NCSTN nicastrin
NDRG1 N-myc downstream regulated 1
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NFAM1 NFAT activating protein with ITAM motif 1
NHEJ1 nonhomologous end-joining factor 1
NKAP NFKB activating protein
NKX2-3 NK2 homeobox 3
NLRC3 NLR family, CARD domain containing 3
NOTCH2 notch 2
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
ONECUT1 one cut homeobox 1
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PAX1 paired box 1
PFDN1 prefoldin subunit 1
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PKNOX1 PBX/knotted 1 homeobox 1
PLA2G3 phospholipase A2, group III
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLCL2 phospholipase C-like 2
POLM polymerase (DNA directed), mu
POU1F1 POU class 1 homeobox 1
POU2F2 POU class 2 homeobox 2
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
PRG3 proteoglycan 3
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PRKCE protein kinase C, epsilon
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRLR prolactin receptor
PSEN1 presenilin 1
PSEN2 presenilin 2
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTK2B protein tyrosine kinase 2 beta
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPRC protein tyrosine phosphatase, receptor type, C
PYCARD PYD and CARD domain containing
RAB27A RAB27A, member RAS oncogene family
RAG1 recombination activating gene 1
RAG2 recombination activating gene 2
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RC3H1 ring finger and CCCH-type domains 1
RC3H2 ring finger and CCCH-type domains 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHOH ras homolog family member H
RIPK2 receptor-interacting serine-threonine kinase 2
RIPK3 receptor-interacting serine-threonine kinase 3
RNF168 ring finger protein 168, E3 ubiquitin protein ligase
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
RORA RAR-related orphan receptor A
RORC RAR-related orphan receptor C
RPL22 ribosomal protein L22
RPS6 ribosomal protein S6
RSAD2 radical S-adenosyl methionine domain containing 2
RUNX2 runt-related transcription factor 2
S100A12 S100 calcium binding protein A12
S100A13 S100 calcium binding protein A13
SATB1 SATB homeobox 1
SBNO2 strawberry notch homolog 2 (Drosophila)
SELPLG selectin P ligand
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SH2D1B SH2 domain containing 1B
SHH sonic hedgehog
SKAP2 src kinase associated phosphoprotein 2
SLA2 Src-like-adaptor 2
SLAMF1 signaling lymphocytic activation molecule family member 1
SLAMF7 SLAM family member 7
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
SMAD3 SMAD family member 3
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOX4 SRY (sex determining region Y)-box 4
SP3 Sp3 transcription factor
SPACA3 sperm acrosome associated 3
SPI1 Spi-1 proto-oncogene
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
STOML2 stomatin (EPB72)-like 2
STX11 syntaxin 11
STXBP2 syntaxin binding protein 2
STXBP3 syntaxin binding protein 3
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYK spleen tyrosine kinase
TBK1 TANK-binding kinase 1
TBX21 T-box 21
TCF3 transcription factor 3
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TGFB1 transforming growth factor, beta 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TICAM1 toll-like receptor adaptor molecule 1
TLR1 toll-like receptor 1
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TLR7 toll-like receptor 7
TLR8 toll-like receptor 8
TNFRSF4 tumor necrosis factor receptor superfamily, member 4
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TOLLIP toll interacting protein
TP53 tumor protein p53
TPD52 tumor protein D52
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TREML2 triggering receptor expressed on myeloid cells-like 2
TUSC2 tumor suppressor candidate 2
TXK TXK tyrosine kinase
TXLNA taxilin alpha
TYRO3 TYRO3 protein tyrosine kinase
TYROBP TYRO protein tyrosine kinase binding protein
UBD ubiquitin D
ULBP1 UL16 binding protein 1
ULBP2 UL16 binding protein 2
ULBP3 UL16 binding protein 3
UNC13D unc-13 homolog D (C. elegans)
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
VAMP7 vesicle-associated membrane protein 7
VAMP8 vesicle-associated membrane protein 8
VAV1 vav 1 guanine nucleotide exchange factor
VCAM1 vascular cell adhesion molecule 1
VPRBP Vpr (HIV-1) binding protein
WAS Wiskott-Aldrich syndrome
WNT1 wingless-type MMTV integration site family, member 1
WNT4 wingless-type MMTV integration site family, member 4
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZBTB1 zinc finger and BTB domain containing 1
ZBTB32 zinc finger and BTB domain containing 32
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF3 zinc finger protein 3
ZNF683 zinc finger protein 683