leukemic stem cell Gene Set

Dataset TISSUES Text-mining Tissue Protein Expression Evidence Scores
Category structural or functional annotations
Type tissue
Description A normal stem or progenitor cell undergoes a mutation, giving rise to an entity that is functionally defined as a leukemic stem cell. The mutated stem cells differentiate into the hematopoietic lineage carrying the defect/s or can remain as immature progenitor cells, the blast cells. (BRENDA Tissue and Enzyme Source Ontology, BTO_0004178)
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Genes

140 proteins co-occuring with the tissue leukemic stem cell in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

Symbol Name Standardized Value
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1 2.39381
CD34 CD34 molecule 1.90239
CD38 CD38 molecule 1.89461
BMI1 BMI1 proto-oncogene, polycomb ring finger 1.63456
CD96 CD96 molecule 1.59226
CLEC12A C-type lectin domain family 12, member A 1.52569
FLT3 fms-related tyrosine kinase 3 1.48364
CD33 CD33 molecule 1.46123
EVPL envoplakin 1.29624
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 1.29489
HOXA9 homeobox A9 1.29085
MEIS1 Meis homeobox 1 1.26844
HOXD9 homeobox D9 1.26755
FANCC Fanconi anemia, complementation group C 1.15717
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 1.13988
KAT6A K(lysine) acetyltransferase 6A 1.13634
NUP98 nucleoporin 98kDa 1.13368
HMSD histocompatibility (minor) serpin domain containing 1.1027
KIAA0020 KIAA0020 1.09253
HOXB4 homeobox B4 1.08369
RUNX1 runt-related transcription factor 1 1.0484
HLF hepatic leukemia factor 1.03171
C1GALT1C1 C1GALT1-specific chaperone 1 0.999344
NCOA2 nuclear receptor coactivator 2 0.997601
VENTX VENT homeobox 0.991944
SMO smoothened, frizzled class receptor 0.978917
PGM2 phosphoglucomutase 2 0.952116
SALL4 spalt-like transcription factor 4 0.945226
FANCA Fanconi anemia, complementation group A 0.896895
PRDM16 PR domain containing 16 0.892223
EVI5 ecotropic viral integration site 5 0.878243
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 0.865577
BCR breakpoint cluster region 0.859258
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 0.854629
KAT6B K(lysine) acetyltransferase 6B 0.846644
SP110 SP110 nuclear body protein 0.83448
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.823594
CD44 CD44 molecule (Indian blood group) 0.823175
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 0.823175
TAL1 T-cell acute lymphocytic leukemia 1 0.81774
SETBP1 SET binding protein 1 0.811056
CBX2 chromobox homolog 2 0.7595
STAT5A signal transducer and activator of transcription 5A 0.748753
IL3 interleukin 3 0.74834
CXCL12 chemokine (C-X-C motif) ligand 12 0.731854
PTEN phosphatase and tensin homolog 0.729797
KDM2B lysine (K)-specific demethylase 2B 0.721166
ABI1 abl-interactor 1 0.718703
MATK megakaryocyte-associated tyrosine kinase 0.712139
FER fer (fps/fes related) tyrosine kinase 0.711729
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3 0.70886
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.683511
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.680656
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 0.675357
CD7 CD7 molecule 0.6182
PRRX1 paired related homeobox 1 0.612958
PROM1 prominin 1 0.608527
DOT1L DOT1-like histone H3K79 methyltransferase 0.606916
CD19 CD19 molecule 0.603295
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 0.600077
FANCF Fanconi anemia, complementation group F 0.599273
NOTCH1 notch 1 0.590036
SPI1 Spi-1 proto-oncogene 0.588031
THY1 Thy-1 cell surface antigen 0.588031
JAK2 Janus kinase 2 0.568823
ETV6 ets variant 6 0.564035
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.554478
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1) 0.553286
IL1RAP interleukin 1 receptor accessory protein 0.55249
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.543359
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.506672
HDAC9 histone deacetylase 9 0.506672
PTH2R parathyroid hormone 2 receptor 0.504318
KITLG KIT ligand 0.501182
AHI1 Abelson helper integration site 1 0.493354
CDKN2A cyclin-dependent kinase inhibitor 2A 0.484376
BLM Bloom syndrome, RecQ helicase-like 0.483986
ALOX5 arachidonate 5-lipoxygenase 0.476589
LMO1 LIM domain only 1 (rhombotin 1) 0.476589
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 0.47348
AXIN1 axin 1 0.468824
PICALM phosphatidylinositol binding clathrin assembly protein 0.468436
ZBTB16 zinc finger and BTB domain containing 16 0.458759
RARA retinoic acid receptor, alpha 0.457987
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 0.457214
ANKRD28 ankyrin repeat domain 28 0.451428
NFIL3 nuclear factor, interleukin 3 regulated 0.449886
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.442578
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.437589
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.42191
HMMR hyaluronan-mediated motility receptor (RHAMM) 0.409351
STAT5B signal transducer and activator of transcription 5B 0.408212
PYCR1 pyrroline-5-carboxylate reductase 1 0.393442
FNDC3A fibronectin type III domain containing 3A 0.388912
CD47 CD47 molecule 0.38552
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4 0.379875
SIRT1 sirtuin 1 0.371245
PRC1 protein regulator of cytokinesis 1 0.350001
INPPL1 inositol polyphosphate phosphatase-like 1 0.346298
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.340388
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 0.340019
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 0.33046
TET2 tet methylcytosine dioxygenase 2 0.323509
GMPS guanine monphosphate synthase 0.32205
HOXA5 homeobox A5 0.308612
ADGRE5 adhesion G protein-coupled receptor E5 0.302118
PIDD1 p53-induced death domain protein 1 0.299062
SALL1 spalt-like transcription factor 1 0.295297
MAPK1 mitogen-activated protein kinase 1 0.292079
SRF serum response factor (c-fos serum response element-binding transcription factor) 0.280364
SIRT6 sirtuin 6 0.276145
JUNB jun B proto-oncogene 0.273696
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.271604
WT1 Wilms tumor 1 0.268137
CCNA1 cyclin A1 0.267446
ERG v-ets avian erythroblastosis virus E26 oncogene homolog 0.264696
HOXD13 homeobox D13 0.263327
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.261284
HLA-C major histocompatibility complex, class I, C 0.249329
MIR223 microRNA 223 0.249006
LCK LCK proto-oncogene, Src family tyrosine kinase 0.245491
HIST2H3PS2 histone cluster 2, H3, pseudogene 2 0.243918
H3F3B H3 histone, family 3B (H3.3B) 0.24052
FANCD2 Fanconi anemia, complementation group D2 0.24052
H3F3A H3 histone, family 3A 0.24052
ASXL1 additional sex combs like transcriptional regulator 1 0.238406
DAP death-associated protein 0.232599
KLF5 Kruppel-like factor 5 (intestinal) 0.23176
TERF1 telomeric repeat binding factor (NIMA-interacting) 1 0.221989
IFNA21 interferon, alpha 21 0.221989
CDX2 caudal type homeobox 2 0.217346
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 0.21673
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.216126
NOG noggin 0.214017
PRTN3 proteinase 3 0.214017
RAG2 recombination activating gene 2 0.213471
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like 0.212936
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 0.199481
ELANE elastase, neutrophil expressed 0.196914
HLA-A major histocompatibility complex, class I, A 0.195485