lethality throughout fetal growth and development Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description death anytime between the completion of organogenesis and birth (Mus: E14 to approximately E18.5) (Mammalian Phenotype Ontology, MP_0006208)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0006208
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Genes

327 gene mutations causing the lethality throughout fetal growth and development phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACO1 aconitase 1, soluble
ACTC1 actin, alpha, cardiac muscle 1
ADAM17 ADAM metallopeptidase domain 17
ADGRA2 adhesion G protein-coupled receptor A2
ADGRL2 adhesion G protein-coupled receptor L2
ADM adrenomedullin
ADRBK1 adrenergic, beta, receptor kinase 1
AIP aryl hydrocarbon receptor interacting protein
AMBRA1 autophagy/beclin-1 regulator 1
ANGPTL4 angiopoietin-like 4
APAF1 apoptotic peptidase activating factor 1
APC adenomatous polyposis coli
ARF6 ADP-ribosylation factor 6
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2
ASXL1 additional sex combs like transcriptional regulator 1
ATE1 arginyltransferase 1
ATMIN ATM interactor
B9D1 B9 protein domain 1
BAG6 BCL2-associated athanogene 6
BICC1 BicC family RNA binding protein 1
BIRC6 baculoviral IAP repeat containing 6
BLM Bloom syndrome, RecQ helicase-like
BMP4 bone morphogenetic protein 4
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
BRCA2 breast cancer 2, early onset
BRD1 bromodomain containing 1
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CALCRL calcitonin receptor-like
CALR calreticulin
CAPN2 calpain 2, (m/II) large subunit
CARM1 coactivator-associated arginine methyltransferase 1
CBFB core-binding factor, beta subunit
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CD274 CD274 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CENPJ centromere protein J
CHD2 chromodomain helicase DNA binding protein 2
CHD7 chromodomain helicase DNA binding protein 7
CHRD chordin
CHST14 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLEC1B C-type lectin domain family 1, member B
CLUAP1 clusterin associated protein 1
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CR1L complement component (3b/4b) receptor 1-like
CREB1 cAMP responsive element binding protein 1
CREBBP CREB binding protein
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CSNK1D casein kinase 1, delta
CTBP2 C-terminal binding protein 2
CUL4B cullin 4B
CUL7 cullin 7
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR4 chemokine (C-X-C motif) receptor 4
DAAM1 dishevelled associated activator of morphogenesis 1
DICER1 dicer 1, ribonuclease type III
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DOCK1 dedicator of cytokinesis 1
E2F3 E2F transcription factor 3
EGFL7 EGF-like-domain, multiple 7
EGFR epidermal growth factor receptor
ELAVL1 ELAV like RNA binding protein 1
EP300 E1A binding protein p300
EPAS1 endothelial PAS domain protein 1
EPO erythropoietin
EPOR erythropoietin receptor
ERBB3 erb-b2 receptor tyrosine kinase 3
ETV5 ets variant 5
F11R F11 receptor
F2 coagulation factor II (thrombin)
F2R coagulation factor II (thrombin) receptor
FBXL20 F-box and leucine-rich repeat protein 20
FBXW8 F-box and WD repeat domain containing 8
FES FES proto-oncogene, tyrosine kinase
FGF19 fibroblast growth factor 19
FGFR1 fibroblast growth factor receptor 1
FGFRL1 fibroblast growth factor receptor-like 1
FKBP1A FK506 binding protein 1A, 12kDa
FLNA filamin A, alpha
FLRT2 fibronectin leucine rich transmembrane protein 2
FLVCR1 feline leukemia virus subgroup C cellular receptor 1
FOXB1 forkhead box B1
FOXF1 forkhead box F1
FOXJ1 forkhead box J1
FOXM1 forkhead box M1
FOXP1 forkhead box P1
FOXQ1 forkhead box Q1
FRAS1 Fraser extracellular matrix complex subunit 1
FUZ fuzzy planar cell polarity protein
GAB1 GRB2-associated binding protein 1
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GATA1 GATA binding protein 1 (globin transcription factor 1)
GATA2 GATA binding protein 2
GATA4 GATA binding protein 4
GBE1 glucan (1,4-alpha-), branching enzyme 1
GDF1 growth differentiation factor 1
GFI1B growth factor independent 1B transcription repressor
GGCX gamma-glutamyl carboxylase
GJA1 gap junction protein, alpha 1, 43kDa
GJB2 gap junction protein, beta 2, 26kDa
GJB5 gap junction protein, beta 5, 31.1kDa
GLRX3 glutaredoxin 3
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GRHL2 grainyhead-like 2 (Drosophila)
GSK3B glycogen synthase kinase 3 beta
GSN gelsolin
HEG1 heart development protein with EGF-like domains 1
HES1 hes family bHLH transcription factor 1
HEXIM1 hexamethylene bis-acetamide inducible 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HHEX hematopoietically expressed homeobox
HOXA13 homeobox A13
HS6ST1 heparan sulfate 6-O-sulfotransferase 1
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HTT huntingtin
IFT140 intraflagellar transport 140
IFT88 intraflagellar transport 88
IGF2 insulin-like growth factor 2
IGF2R insulin-like growth factor 2 receptor
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL6ST interleukin 6 signal transducer
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
INSM1 insulinoma-associated 1
INTU inturned planar cell polarity protein
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
JAK2 Janus kinase 2
JARID2 jumonji, AT rich interactive domain 2
JUN jun proto-oncogene
JUP junction plakoglobin
KAT6A K(lysine) acetyltransferase 6A
KDM2B lysine (K)-specific demethylase 2B
KIDINS220 kinase D-interacting substrate, 220kDa
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KITLG KIT ligand
KLF1 Kruppel-like factor 1 (erythroid)
KLF2 Kruppel-like factor 2
KLF3 Kruppel-like factor 3 (basic)
KMT2A lysine (K)-specific methyltransferase 2A
LAMA5 laminin, alpha 5
LARP7 La ribonucleoprotein domain family, member 7
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LHX2 LIM homeobox 2
LIG1 ligase I, DNA, ATP-dependent
LIG4 ligase IV, DNA, ATP-dependent
LRP1 low density lipoprotein receptor-related protein 1
LSR lipolysis stimulated lipoprotein receptor
LTBP1 latent transforming growth factor beta binding protein 1
LY6E lymphocyte antigen 6 complex, locus E
MAB21L2 mab-21-like 2 (C. elegans)
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAPK14 mitogen-activated protein kinase 14
MCM4 minichromosome maintenance complex component 4
MECOM MDS1 and EVI1 complex locus
MED31 mediator complex subunit 31
MEGF8 multiple EGF-like-domains 8
MEIS1 Meis homeobox 1
MEN1 multiple endocrine neoplasia I
MET MET proto-oncogene, receptor tyrosine kinase
MFN2 mitofusin 2
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MKL2 MKL/myocardin-like 2
MKS1 Meckel syndrome, type 1
MORF4L1 mortality factor 4 like 1
MTF1 metal-regulatory transcription factor 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYB v-myb avian myeloblastosis viral oncogene homolog
MYH10 myosin, heavy chain 10, non-muscle
MYL2 myosin, light chain 2, regulatory, cardiac, slow
NCOA6 nuclear receptor coactivator 6
NCOR1 nuclear receptor corepressor 1
NCOR2 nuclear receptor corepressor 2
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NEK7 NIMA-related kinase 7
NF1 neurofibromin 1
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFE2L1 nuclear factor, erythroid 2-like 1
NOG noggin
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NPRL3 nitrogen permease regulator-like 3 (S. cerevisiae)
NUAK2 NUAK family, SNF1-like kinase, 2
OSR1 odd-skipped related transciption factor 1
OVOL1 ovo-like zinc finger 1
OXSR1 oxidative stress responsive 1
PAK1IP1 PAK1 interacting protein 1
PALLD palladin, cytoskeletal associated protein
PAM peptidylglycine alpha-amidating monooxygenase
PARVA parvin, alpha
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PAX2 paired box 2
PAX3 paired box 3
PBRM1 polybromo 1
PBX1 pre-B-cell leukemia homeobox 1
PCSK6 proprotein convertase subtilisin/kexin type 6
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDGFB platelet-derived growth factor beta polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDPN podoplanin
PDS5B PDS5 cohesin associated factor B
PHACTR4 phosphatase and actin regulator 4
PHF13 PHD finger protein 13
PHOX2B paired-like homeobox 2b
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PITX2 paired-like homeodomain 2
PKD1 polycystic kidney disease 1 (autosomal dominant)
PKD1L1 polycystic kidney disease 1 like 1
PKD2 polycystic kidney disease 2 (autosomal dominant)
PKNOX1 PBX/knotted 1 homeobox 1
PLVAP plasmalemma vesicle associated protein
PON3 paraoxonase 3
POR P450 (cytochrome) oxidoreductase
POU2F1 POU class 2 homeobox 1
PRDM1 PR domain containing 1, with ZNF domain
PRKD1 protein kinase D1
PROS1 protein S (alpha)
PROX1 prospero homeobox 1
PSEN1 presenilin 1
PTCH1 patched 1
PTH1R parathyroid hormone 1 receptor
PTK2 protein tyrosine kinase 2
PTPN9 protein tyrosine phosphatase, non-receptor type 9
RAD50 RAD50 homolog (S. cerevisiae)
RAD9B RAD9 homolog B (S. pombe)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RAI1 retinoic acid induced 1
RAMP2 receptor (G protein-coupled) activity modifying protein 2
RAP1B RAP1B, member of RAS oncogene family
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RASA3 RAS p21 protein activator 3
RB1 retinoblastoma 1
RB1CC1 RB1-inducible coiled-coil 1
RCE1 Ras converting CAAX endopeptidase 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RFWD2 ring finger and WD repeat domain 2, E3 ubiquitin protein ligase
RICTOR RPTOR independent companion of MTOR, complex 2
RNF4 ring finger protein 4
RTL1 retrotransposon-like 1
RUNX1 runt-related transcription factor 1
RUNX2 runt-related transcription factor 2
RXRA retinoid X receptor, alpha
RYR1 ryanodine receptor 1 (skeletal)
RYR2 ryanodine receptor 2 (cardiac)
S1PR1 sphingosine-1-phosphate receptor 1
SALL4 spalt-like transcription factor 4
SAV1 salvador family WW domain containing protein 1
SCRIB scribbled planar cell polarity protein
SEC24B SEC24 family member B
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SENP1 SUMO1/sentrin specific peptidase 1
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1
SHH sonic hedgehog
SHOX2 short stature homeobox 2
SIRT1 sirtuin 1
SKI SKI proto-oncogene
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLX4 SLX4 structure-specific endonuclease subunit
SMN1 survival of motor neuron 1, telomeric
SOCS3 suppressor of cytokine signaling 3
SOD2 superoxide dismutase 2, mitochondrial
SOS1 son of sevenless homolog 1 (Drosophila)
SOX18 SRY (sex determining region Y)-box 18
SOX4 SRY (sex determining region Y)-box 4
SP2 Sp2 transcription factor
SPEN spen family transcriptional repressor
SPI1 Spi-1 proto-oncogene
SPTAN1 spectrin, alpha, non-erythrocytic 1
SPTBN1 spectrin, beta, non-erythrocytic 1
SREBF1 sterol regulatory element binding transcription factor 1
SRSF10 serine/arginine-rich splicing factor 10
SSBP3 single stranded DNA binding protein 3
STAG1 stromal antigen 1
STIM1 stromal interaction molecule 1
STK11 serine/threonine kinase 11
STX1A syntaxin 1A (brain)
SUMO1 small ubiquitin-like modifier 1
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TACC3 transforming, acidic coiled-coil containing protein 3
TAL1 T-cell acute lymphocytic leukemia 1
TBK1 TANK-binding kinase 1
TBX2 T-box 2
TBX3 T-box 3
TCEA1 transcription elongation factor A (SII), 1
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box)
TCTN1 tectonic family member 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFB1 transforming growth factor, beta 1
TGFBR3 transforming growth factor, beta receptor III
TH tyrosine hydroxylase
THOC1 THO complex 1
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1
TLE3 transducin-like enhancer of split 3
TLL1 tolloid-like 1
TMEM231 transmembrane protein 231
TMOD3 tropomodulin 3 (ubiquitous)
TP53 tumor protein p53
TRAF2 TNF receptor-associated factor 2
TRIM71 tripartite motif containing 71, E3 ubiquitin protein ligase
TRIO trio Rho guanine nucleotide exchange factor
TRPM6 transient receptor potential cation channel, subfamily M, member 6
TSC2 tuberous sclerosis 2
TSTA3 tissue specific transplantation antigen P35B
TULP3 tubby like protein 3
UBC ubiquitin C
UBE2L3 ubiquitin-conjugating enzyme E2L 3
UBE4B ubiquitination factor E4B
VEGFA vascular endothelial growth factor A
VEGFC vascular endothelial growth factor C
VEZF1 vascular endothelial zinc finger 1
WDR19 WD repeat domain 19
WNT1 wingless-type MMTV integration site family, member 1
WT1 Wilms tumor 1
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
YBX1 Y box binding protein 1
YY1 YY1 transcription factor
ZBTB7A zinc finger and BTB domain containing 7A
ZFP57 ZFP57 zinc finger protein
ZFPM1 zinc finger protein, FOG family member 1
ZFPM2 zinc finger protein, FOG family member 2