learning disability Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A specific developmental disorder that involves difficulty in scholastic skills such as reading, writing, spelling, reasoning, recalling and/or organizing information resulting from the brain's inability to receive and process information. (Human Disease Ontology, DOID_8927)
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Genes

303 genes co-occuring with the disease learning disability in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
DYX1C1 dyslexia susceptibility 1 candidate 1 3.03376
KIAA0319 KIAA0319 2.99815
DCDC2 doublecortin domain containing 2 2.88676
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 2.00056
MRPL19 mitochondrial ribosomal protein L19 1.92389
GCFC2 GC-rich sequence DNA-binding factor 2 1.91267
KIAA0319L KIAA0319-like 1.82595
IMPACT impact RWD domain protein 1.64442
TDP2 tyrosyl-DNA phosphodiesterase 2 1.53172
ZNF280D zinc finger protein 280D 1.5014
DOCK4 dedicator of cytokinesis 4 1.37687
LRRC37A3 leucine rich repeat containing 37, member A3 1.35986
LRRC37A leucine rich repeat containing 37A 1.35986
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) 1.33152
ARL17A ADP-ribosylation factor-like 17A 1.31581
TMEM257 transmembrane protein 257 1.31581
ARL17B ADP-ribosylation factor-like 17B 1.31581
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein 1.30139
PTCHD1 patched domain containing 1 1.22345
CNTNAP2 contactin associated protein-like 2 1.19877
NF1 neurofibromin 1 1.18669
MORN4 MORN repeat containing 4 1.18109
FMR1NB fragile X mental retardation 1 neighbor 1.16735
KAAG1 kidney associated antigen 1 1.16435
SLC47A2 solute carrier family 47 (multidrug and toxin extrusion), member 2 1.14985
ACOT13 acyl-CoA thioesterase 13 1.13289
FMR1 fragile X mental retardation 1 1.1173
SNX13 sorting nexin 13 1.10846
CDH8 cadherin 8, type 2 1.09713
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 1.09335
LRRC37A4P leucine rich repeat containing 37, member A4, pseudogene 1.09125
DCDC5 doublecortin domain containing 5 1.08957
FOXP2 forkhead box P2 1.08579
TWISTNB TWIST neighbor 1.07866
PLA2G4B phospholipase A2, group IVB (cytosolic) 1.03114
FMR1-AS1 FMR1 antisense RNA 1 1.01512
FERD3L Fer3-like bHLH transcription factor 1.00457
CMIP c-Maf inducing protein 0.992752
DCX doublecortin 0.988535
TBX1 T-box 1 0.9839
ZNF778 zinc finger protein 778 0.9696
NTAN1 N-terminal asparagine amidase 0.952856
CNTNAP5 contactin associated protein-like 5 0.947019
SLITRK2 SLIT and NTRK-like family, member 2 0.94369
MECP2 methyl CpG binding protein 2 0.939534
NEGR1 neuronal growth regulator 1 0.9238
AFF2 AF4/FMR2 family, member 2 0.915551
PAPOLG poly(A) polymerase gamma 0.908142
NODAL nodal growth differentiation factor 0.897051
SCLT1 sodium channel and clathrin linker 1 0.876148
DRD4 dopamine receptor D4 0.862228
COLEC11 collectin sub-family member 11 0.851583
SEMA4F sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F 0.849945
NEUROD6 neuronal differentiation 6 0.847078
TMOD2 tropomodulin 2 (neuronal) 0.838885
TUBGCP5 tubulin, gamma complex associated protein 5 0.837656
MKKS McKusick-Kaufman syndrome 0.826999
DGKI diacylglycerol kinase, iota 0.822077
CXXC5 CXXC finger protein 5 0.815924
RNF135 ring finger protein 135 0.814283
FAM215A family with sequence similarity 215, member A (non-protein coding) 0.81018
KANSL1 KAT8 regulatory NSL complex subunit 1 0.808539
CEP164 centrosomal protein 164kDa 0.793361
ALDH5A1 aldehyde dehydrogenase 5 family, member A1 0.758601
GRIK4 glutamate receptor, ionotropic, kainate 4 0.755342
GSPT2 G1 to S phase transition 2 0.750864
SEPHS1 selenophosphate synthetase 1 0.748017
THRB thyroid hormone receptor, beta 0.74761
COPS2 COP9 signalosome subunit 2 0.745578
GTF2I general transcription factor IIi 0.743954
LRRTM1 leucine rich repeat transmembrane neuronal 1 0.728547
TCF12 transcription factor 12 0.725716
TMOD3 tropomodulin 3 (ubiquitous) 0.709975
ZNF74 zinc finger protein 74 0.700722
MYO18B myosin XVIIIB 0.700722
VARS valyl-tRNA synthetase 0.694301
AUH AU RNA binding protein/enoyl-CoA hydratase 0.689893
PCSK6 proprotein convertase subtilisin/kexin type 6 0.685491
MKRN3 makorin ring finger protein 3 0.6791
PLCB2 phospholipase C, beta 2 0.664769
DRD5 dopamine receptor D5 0.658026
WDR13 WD repeat domain 13 0.644192
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 0.641433
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled 0.636708
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain 0.636315
TMOD4 tropomodulin 4 (muscle) 0.632384
CCT2 chaperonin containing TCP1, subunit 2 (beta) 0.631598
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.62728
CAMK2G calcium/calmodulin-dependent protein kinase II gamma 0.626888
MYO5B myosin VB 0.626103
NPAS3 neuronal PAS domain protein 3 0.624535
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 0.622967
ADGRL3 adhesion G protein-coupled receptor L3 0.622967
LSAMP limbic system-associated membrane protein 0.619834
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.616312
A1CF APOBEC1 complementation factor 0.597961
DRD3 dopamine receptor D3 0.594064
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.590948
PSAP prosaposin 0.586276
PDE7B phosphodiesterase 7B 0.584719
LVRN laeverin 0.583552
PURA purine-rich element binding protein A 0.578883
MEIS2 Meis homeobox 2 0.570718
PNMA2 paraneoplastic Ma antigen 2 0.569941
TK2 thymidine kinase 2, mitochondrial 0.567609
ATP10A ATPase, class V, type 10A 0.567609
FSIP1 fibrous sheath interacting protein 1 0.56722
GNPTG N-acetylglucosamine-1-phosphate transferase, gamma subunit 0.564889
MC5R melanocortin 5 receptor 0.559839
SYN1 synapsin I 0.559062
MED12 mediator complex subunit 12 0.542767
SPEG SPEG complex locus 0.542379
GLRA2 glycine receptor, alpha 2 0.53928
DLX1 distal-less homeobox 1 0.53928
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.538893
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase 0.538118
DYM dymeclin 0.533088
NCOA2 nuclear receptor coactivator 2 0.521502
PXDN peroxidasin 0.520731
MSI2 musashi RNA-binding protein 2 0.519575
GYLTL1B glycosyltransferase-like 1B 0.513033
FLNA filamin A, alpha 0.513033
IQCB1 IQ motif containing B1 0.510344
ZBTB20 zinc finger and BTB domain containing 20 0.510344
RAP2A RAP2A, member of RAS oncogene family 0.508424
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.507657
OTX1 orthodenticle homeobox 1 0.506507
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) 0.505356
AUTS2 autism susceptibility candidate 2 0.497703
CPS1 carbamoyl-phosphate synthase 1, mitochondrial 0.487788
SNRPN small nuclear ribonucleoprotein polypeptide N 0.485125
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 0.480566
PRMT2 protein arginine methyltransferase 2 0.480566
NLGN4X neuroligin 4, X-linked 0.476772
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.475255
SOD1 superoxide dismutase 1, soluble 0.471846
CDK5RAP2 CDK5 regulatory subunit associated protein 2 0.470711
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 0.463149
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5 0.462394
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.460506
SIM1 single-minded family bHLH transcription factor 1 0.457487
CYFIP1 cytoplasmic FMR1 interacting protein 1 0.454093
NDE1 nudE neurodevelopment protein 1 0.450324
EFS embryonal Fyn-associated substrate 0.4443
ASIC2 acid sensing (proton gated) ion channel 2 0.442042
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled 0.434524
HEMK1 HemK methyltransferase family member 1 0.432646
GLDC glycine dehydrogenase (decarboxylating) 0.428891
HIRA histone cell cycle regulator 0.428891
DPP6 dipeptidyl-peptidase 6 0.42139
CDH4 cadherin 4, type 1, R-cadherin (retinal) 0.420641
KDM5C lysine (K)-specific demethylase 5C 0.411657
BHLHE41 basic helix-loop-helix family, member e41 0.405305
TIMELESS timeless circadian clock 0.403811
ADD3 adducin 3 (gamma) 0.394863
HAL histidine ammonia-lyase 0.390397
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits 0.388166
BHLHE40 basic helix-loop-helix family, member e40 0.384451
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 0.383708
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2 0.382966
FTCD formimidoyltransferase cyclodeaminase 0.379256
APOPT1 apoptogenic 1, mitochondrial 0.378885
DLAT dihydrolipoamide S-acetyltransferase 0.374809
KIF3A kinesin family member 3A 0.373328
ZNF804A zinc finger protein 804A 0.370368
NFIC nuclear factor I/C (CCAAT-binding transcription factor) 0.369628
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 0.36741
TRIM32 tripartite motif containing 32 0.365562
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.364824
PCDH11X protocadherin 11 X-linked 0.363347
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 0.362609
FBXW2 F-box and WD repeat domain containing 2 0.362239
GAMT guanidinoacetate N-methyltransferase 0.357814
SPTBN1 spectrin, beta, non-erythrocytic 1 0.353763
METTL13 methyltransferase like 13 0.352291
CSPG5 chondroitin sulfate proteoglycan 5 (neuroglycan C) 0.351923
GRIA1 glutamate receptor, ionotropic, AMPA 1 0.350084
UBE3A ubiquitin protein ligase E3A 0.348981
RELN reelin 0.347144
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 0.341639
SPRED1 sprouty-related, EVH1 domain containing 1 0.33944
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 0.337975
KCNK2 potassium channel, two pore domain subfamily K, member 2 0.334681
MAPT microtubule-associated protein tau 0.332487
SLURP1 secreted LY6/PLAUR domain containing 1 0.331025
CNTF ciliary neurotrophic factor 0.330295
TSC2 tuberous sclerosis 2 0.328834
ICT1 immature colon carcinoma transcript 1 0.328105
LSR lipolysis stimulated lipoprotein receptor 0.325187
ADD2 adducin 2 (beta) 0.324823
NMS neuromedin S 0.322637
DLD dihydrolipoamide dehydrogenase 0.321909
DCLK1 doublecortin-like kinase 1 0.320817
CGA glycoprotein hormones, alpha polypeptide 0.319726
NCAN neurocan 0.319363
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.316819
MYBPC1 myosin binding protein C, slow type 0.313915
DLG3 discs, large homolog 3 (Drosophila) 0.313189
CRHR1 corticotropin releasing hormone receptor 1 0.313189
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.311014
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) 0.310652
PCNT pericentrin 0.306672
NRP2 neuropilin 2 0.303781
SEMA6C sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C 0.303059
TPH1 tryptophan hydroxylase 1 0.300173
MYRF myelin regulatory factor 0.299092
G6PC3 glucose 6 phosphatase, catalytic, 3 0.297291
SPG11 spastic paraplegia 11 (autosomal recessive) 0.296931
SEPT2 septin 2 0.279011
AP1M2 adaptor-related protein complex 1, mu 2 subunit 0.277227
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.272953
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal) 0.272597
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.272241
SGCE sarcoglycan, epsilon 0.269043
EYA1 EYA transcriptional coactivator and phosphatase 1 0.268332
DEDD death effector domain containing 0.267622
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase 0.267622
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 0.264431
OMG oligodendrocyte myelin glycoprotein 0.263722
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter) 0.263014
NRGN neurogranin (protein kinase C substrate, RC3) 0.260891
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 0.260891
VCP valosin containing protein 0.260538
ASL argininosuccinate lyase 0.259124
UBIAD1 UbiA prenyltransferase domain containing 1 0.255594
GRIA4 glutamate receptor, ionotropic, AMPA 4 0.254183
ADRA2A adrenoceptor alpha 2A 0.253479
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.251015
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.250663
KDM6A lysine (K)-specific demethylase 6A 0.249257
AP2M1 adaptor-related protein complex 2, mu 1 subunit 0.246799
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 0.244696
EEA1 early endosome antigen 1 0.242595
GABARAP GABA(A) receptor-associated protein 0.241546
NRXN1 neurexin 1 0.241546
NF2 neurofibromin 2 (merlin) 0.237706
MCPH1 microcephalin 1 0.237357
PDLIM1 PDZ and LIM domain 1 0.234225
NIPBL Nipped-B homolog (Drosophila) 0.229024
KMT2B lysine (K)-specific methyltransferase 2B 0.227642
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 0.222822
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) 0.220424
GLUD1 glutamate dehydrogenase 1 0.218374
PHB2 prohibitin 2 0.217693
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 0.212271
GJB2 gap junction protein, beta 2, 26kDa 0.207245
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 0.203933
GRN granulin 0.203604
LPP LIM domain containing preferred translocation partner in lipoma 0.197742
CAMP cathelicidin antimicrobial peptide 0.196779
TARDBP TAR DNA binding protein 0.19582
S100B S100 calcium binding protein B 0.194548
PAX6 paired box 6 0.193915
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.191408
PROP1 PROP paired-like homeobox 1 0.191408
TARS threonyl-tRNA synthetase 0.190476
DSC3 desmocollin 3 0.188022
NDN necdin, melanoma antigen (MAGE) family member 0.186811
NME1 NME/NM23 nucleoside diphosphate kinase 1 0.17896
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.177301
ENPEP glutamyl aminopeptidase (aminopeptidase A) 0.177301
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.177029
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 0.175679
TCF4 transcription factor 4 0.171535
TXNRD2 thioredoxin reductase 2 0.170789
TRPV6 transient receptor potential cation channel, subfamily V, member 6 0.170544
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 0.166544
OCA2 oculocutaneous albinism II 0.162908
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin) 0.161523
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide 0.15948
CNOT2 CCR4-NOT transcription complex, subunit 2 0.158951
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.158097
CD6 CD6 molecule 0.158013
CBS cystathionine-beta-synthase 0.148812
PRNP prion protein 0.147881
APOH apolipoprotein H (beta-2-glycoprotein I) 0.145085
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 0.14496
TES testin LIM domain protein 0.1449
CCL20 chemokine (C-C motif) ligand 20 0.144169
MBP myelin basic protein 0.143994
MAPK14 mitogen-activated protein kinase 14 0.142685
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 0.140692
GK glycerol kinase 0.139234
PROX1 prospero homeobox 1 0.139211
CALB2 calbindin 2 0.139132
RTN4R reticulon 4 receptor 0.139057
DRD2 dopamine receptor D2 0.138223
RRM2 ribonucleotide reductase M2 0.138083
CTTN cortactin 0.137672
RHCE Rh blood group, CcEe antigens 0.137563
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.137527
F5 coagulation factor V (proaccelerin, labile factor) 0.137073
MOG myelin oligodendrocyte glycoprotein 0.136786
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 0.13677
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 0.136754
TCN2 transcobalamin II 0.136196
SPTB spectrin, beta, erythrocytic 0.136161
INA internexin neuronal intermediate filament protein, alpha 0.136054
KAT5 K(lysine) acetyltransferase 5 0.135577
PSEN2 presenilin 2 0.135336
ACHE acetylcholinesterase (Yt blood group) 0.135088
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 0.134463
PSEN1 presenilin 1 0.127342