leading edge membrane Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description The portion of the plasma membrane surrounding the leading edge of a motile cell. (Gene Ontology, GO_0031256)
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Genes

328 proteins co-occuring with the leading edge membrane cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
CNTNAP1 contactin associated protein 1 1.83474
NFASC neurofascin 1.4938
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase 1.46948
MAG myelin associated glycoprotein 1.45816
ACHE acetylcholinesterase (Yt blood group) 1.28997
CNTN2 contactin 2 (axonal) 1.25285
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 1.23348
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 1.1685
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 1.11072
DNAH8 dynein, axonemal, heavy chain 8 0.978074
FGD3 FYVE, RhoGEF and PH domain containing 3 0.950189
ANK1 ankyrin 1, erythrocytic 0.881477
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 0.878712
GLDN gliomedin 0.859392
PRX periaxin 0.848828
UGT8 UDP glycosyltransferase 8 0.784156
GPM6A glycoprotein M6A 0.759069
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 0.752716
MBP myelin basic protein 0.739163
NRCAM neuronal cell adhesion molecule 0.701744
TPRKB TP53RK binding protein 0.696026
SYP synaptophysin 0.664664
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2 0.644001
DCP1B decapping mRNA 1B 0.643572
NTN3 netrin 3 0.634586
TBC1D24 TBC1 domain family, member 24 0.631598
WDFY1 WD repeat and FYVE domain containing 1 0.60655
NCAM1 neural cell adhesion molecule 1 0.576747
CADM2 cell adhesion molecule 2 0.57008
CDK20 cyclin-dependent kinase 20 0.568001
ICAM5 intercellular adhesion molecule 5, telencephalin 0.555145
INCA1 inhibitor of CDK, cyclin A1 interacting protein 1 0.547297
ALS2 amyotrophic lateral sclerosis 2 (juvenile) 0.535361
NRG1 neuregulin 1 0.535361
SCN8A sodium channel, voltage gated, type VIII alpha subunit 0.533309
CNTN4 contactin 4 0.51694
ANK2 ankyrin 2, neuronal 0.50879
TRPV1 transient receptor potential cation channel, subfamily V, member 1 0.507977
CADM4 cell adhesion molecule 4 0.502288
SPTBN4 spectrin, beta, non-erythrocytic 4 0.501476
BCHE butyrylcholinesterase 0.499447
KCNC1 potassium channel, voltage gated Shaw related subfamily C, member 1 0.49499
GJB1 gap junction protein, beta 1, 32kDa 0.492561
DACT2 dishevelled-binding antagonist of beta-catenin 2 0.487307
NT5E 5'-nucleotidase, ecto (CD73) 0.485693
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 0.480453
PLA2G1B phospholipase A2, group IB (pancreas) 0.479647
CALCA calcitonin-related polypeptide alpha 0.476831
DOCK8 dedicator of cytokinesis 8 0.470406
SCN10A sodium channel, voltage gated, type X alpha subunit 0.4672
OMG oligodendrocyte myelin glycoprotein 0.463198
MIR27B microRNA 27b 0.462398
EPB41 erythrocyte membrane protein band 4.1 0.460001
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor 0.451631
NTNG2 netrin G2 0.444085
TAC1 tachykinin, precursor 1 0.428284
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 0.417685
GJC3 gap junction protein, gamma 3, 30.2kDa 0.402859
GAP43 growth associated protein 43 0.399751
L1CAM L1 cell adhesion molecule 0.399363
GRIK2 glutamate receptor, ionotropic, kainate 2 0.397423
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 0.396648
FAM155B family with sequence similarity 155, member B 0.368536
SOD1 superoxide dismutase 1, soluble 0.360515
CCNF cyclin F 0.360133
MCF2 MCF.2 cell line derived transforming sequence 0.359752
CD1C CD1c molecule 0.349484
SYT2 synaptotagmin II 0.344556
HCN3 hyperpolarization activated cyclic nucleotide gated potassium channel 3 0.344178
CLDN11 claudin 11 0.343421
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 0.339261
ATP11A ATPase, class VI, type 11A 0.338506
B3GAT1 beta-1,3-glucuronyltransferase 1 0.325327
FGD1 FYVE, RhoGEF and PH domain containing 1 0.321201
TNC tenascin C 0.31596
ERBB3 erb-b2 receptor tyrosine kinase 3 0.315212
CADM3 cell adhesion molecule 3 0.315212
PLIN4 perilipin 4 0.314091
TRPA1 transient receptor potential cation channel, subfamily A, member 1 0.30924
DHH desert hedgehog 0.30924
THY1 Thy-1 cell surface antigen 0.308494
LSAMP limbic system-associated membrane protein 0.30626
MYO1D myosin ID 0.304771
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6 0.294748
NGFR nerve growth factor receptor 0.291787
SHF Src homology 2 domain containing F 0.290678
CNTNAP2 contactin associated protein-like 2 0.285507
SCN3A sodium channel, voltage gated, type III alpha subunit 0.284769
DOLK dolichol kinase 0.284401
SRSF9 serine/arginine-rich splicing factor 9 0.278877
PNPLA2 patatin-like phospholipase domain containing 2 0.277406
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 0.277406
SYN1 synapsin I 0.277038
MPZ myelin protein zero 0.273
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.272633
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.272267
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.272267
PLP1 proteolipid protein 1 0.269335
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase 0.267139
LPCAT3 lysophosphatidylcholine acyltransferase 3 0.26385
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 0.262025
NGF nerve growth factor (beta polypeptide) 0.259837
STX1A syntaxin 1A (brain) 0.250026
GAN gigaxonin 0.246046
PMP22 peripheral myelin protein 22 0.243879
MAP1B microtubule-associated protein 1B 0.242797
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 0.239557
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) 0.237401
NTN1 netrin 1 0.234891
RTN4 reticulon 4 0.215063
USO1 USO1 vesicle transport factor 0.207794
NMNAT1 nicotinamide nucleotide adenylyltransferase 1 0.207108
NPS neuropeptide S 0.191456
PRSS21 protease, serine, 21 (testisin) 0.191135
CLMP CXADR-like membrane protein 0.189539
ACOT7 acyl-CoA thioesterase 7 0.177154
CAPN2 calpain 2, (m/II) large subunit 0.170371
AP1M2 adaptor-related protein complex 1, mu 2 subunit 0.170371
AP2M1 adaptor-related protein complex 2, mu 1 subunit 0.168847
CKAP4 cytoskeleton-associated protein 4 0.168101
DCC DCC netrin 1 receptor 0.167611
CAND2 cullin-associated and neddylation-dissociated 2 (putative) 0.167611
ATXN2 ataxin 2 0.166884
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.164089
ACKR1 atypical chemokine receptor 1 (Duffy blood group) 0.163641
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 0.16298
MAPT microtubule-associated protein tau 0.16298
CA2 carbonic anhydrase II 0.162763
DNM2 dynamin 2 0.161905
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.161275
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.160053
PNPLA6 patatin-like phospholipase domain containing 6 0.158129
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) 0.156688
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) 0.141181
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.141168
CDC42 cell division cycle 42 0.140788
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.139487
CTTN cortactin 0.138776
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.138204
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 0.138158
PLEK pleckstrin 0.137964
GRM1 glutamate receptor, metabotropic 1 0.137515
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 0.137051
VAV2 vav 2 guanine nucleotide exchange factor 0.136576
PKN1 protein kinase N1 0.136087
ELMO3 engulfment and cell motility 3 0.135949
CRK v-crk avian sarcoma virus CT10 oncogene homolog 0.135825
EZR ezrin 0.135776
TFPT TCF3 (E2A) fusion partner (in childhood Leukemia) 0.135415
ARF6 ADP-ribosylation factor 6 0.134754
SPRY2 sprouty homolog 2 (Drosophila) 0.134009
MSN moesin 0.133845
GRB2 growth factor receptor-bound protein 2 0.133268
PXN paxillin 0.132877
SPATA13 spermatogenesis associated 13 0.13279
FSCN1 fascin actin-bundling protein 1 0.132553
PTPN20 protein tyrosine phosphatase, non-receptor type 20 0.132334
NCKIPSD NCK interacting protein with SH3 domain 0.132219
SASH1 SAM and SH3 domain containing 1 0.131915
RDX radixin 0.131731
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) 0.131592
SWAP70 SWAP switching B-cell complex 70kDa subunit 0.131082
ITGB1BP1 integrin beta 1 binding protein 1 0.131039
CYTH4 cytohesin 4 0.130987
VCL vinculin 0.130918
MTMR9 myotubularin related protein 9 0.130822
TIAM1 T-cell lymphoma invasion and metastasis 1 0.130787
IQGAP1 IQ motif containing GTPase activating protein 1 0.13076
FGD5 FYVE, RhoGEF and PH domain containing 5 0.130681
ARHGAP35 Rho GTPase activating protein 35 0.130574
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2 0.130402
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 0.130366
SCARB2 scavenger receptor class B, member 2 0.130357
DOCK1 dedicator of cytokinesis 1 0.130135
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 0.130098
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.130014
CD36 CD36 molecule (thrombospondin receptor) 0.129843
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.129689
NEXN nexilin (F actin binding protein) 0.12965
PLCD1 phospholipase C, delta 1 0.129325
MYO18A myosin XVIIIA 0.129224
MAP3K13 mitogen-activated protein kinase kinase kinase 13 0.129113
GBP5 guanylate binding protein 5 0.128876
SCARB1 scavenger receptor class B, member 1 0.12874
FN1 fibronectin 1 0.128666
ARHGAP24 Rho GTPase activating protein 24 0.128581
ELMO2 engulfment and cell motility 2 0.128474
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa 0.12842
VCAN versican 0.128366
IQGAP2 IQ motif containing GTPase activating protein 2 0.12819
PLCG1 phospholipase C, gamma 1 0.128102
PARD3B par-3 family cell polarity regulator beta 0.128035
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5 0.128012
PARVB parvin, beta 0.127934
PARVG parvin, gamma 0.127694
EPS8 epidermal growth factor receptor pathway substrate 8 0.127637
FLNA filamin A, alpha 0.127567
NRG4 neuregulin 4 0.127497
PLEK2 pleckstrin 2 0.127332
MYO6 myosin VI 0.12714
GMFG glia maturation factor, gamma 0.127018
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 0.126982
RHOQ ras homolog family member Q 0.126982
PLS1 plastin 1 0.126969
MCF2L MCF.2 cell line derived transforming sequence-like 0.126945
TESC tescalcin 0.126945
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 0.126871
CALD1 caldesmon 1 0.126834
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 0.126797
CYTH1 cytohesin 1 0.126697
MTMR6 myotubularin related protein 6 0.126621
AIF1 allograft inflammatory factor 1 0.12652
JUN jun proto-oncogene 0.126237
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase 0.126224
MAP3K12 mitogen-activated protein kinase kinase kinase 12 0.126079
CPVL carboxypeptidase, vitellogenic-like 0.125987
FHOD1 formin homology 2 domain containing 1 0.125839
VAV1 vav 1 guanine nucleotide exchange factor 0.125799
EGFR epidermal growth factor receptor 0.12569
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4 0.125622
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 0.125567
SPRR1A small proline-rich protein 1A 0.125539
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.125442
ARHGAP1 Rho GTPase activating protein 1 0.125046
CDC42EP5 CDC42 effector protein (Rho GTPase binding) 5 0.124945
RECK reversion-inducing-cysteine-rich protein with kazal motifs 0.124902
GAS7 growth arrest-specific 7 0.124843
PLS3 plastin 3 0.124799
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 0.124769
VAV3 vav 3 guanine nucleotide exchange factor 0.124681
NOX3 NADPH oxidase 3 0.124666
AKAP11 A kinase (PRKA) anchor protein 11 0.124577
LAYN layilin 0.124547
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.12429
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.124274
BCAR1 breast cancer anti-estrogen resistance 1 0.123949
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6 0.123918
CD2AP CD2-associated protein 0.12387
PLD2 phospholipase D2 0.123727
ARHGAP22 Rho GTPase activating protein 22 0.123695
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated) 0.123436
GRAP2 GRB2-related adaptor protein 2 0.123436
BTK Bruton agammaglobulinemia tyrosine kinase 0.123088
MAP3K10 mitogen-activated protein kinase kinase kinase 10 0.12302
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 0.122918
ARF5 ADP-ribosylation factor 5 0.122901
EPHB4 EPH receptor B4 0.122747
SPHK1 sphingosine kinase 1 0.122747
INPP5A inositol polyphosphate-5-phosphatase, 40kDa 0.12266
MBTPS1 membrane-bound transcription factor peptidase, site 1 0.12266
SNX18 sorting nexin 18 0.122308
RUFY1 RUN and FYVE domain containing 1 0.122128
SNX33 sorting nexin 33 0.122038
PPP3R2 protein phosphatase 3, regulatory subunit B, beta 0.121965
CRIP1 cysteine-rich protein 1 (intestinal) 0.121594
TWF2 twinfilin actin binding protein 2 0.121499
TESK1 testis-specific kinase 1 0.121385
RAP2B RAP2B, member of RAS oncogene family 0.121154
SAR1A secretion associated, Ras related GTPase 1A 0.12082
ARF3 ADP-ribosylation factor 3 0.12078
RAB1B RAB1B, member RAS oncogene family 0.12064
ASB2 ankyrin repeat and SOCS box containing 2 0.1206
ARHGAP31 Rho GTPase activating protein 31 0.120559
BCAR3 breast cancer anti-estrogen resistance 3 0.119618
RAB10 RAB10, member RAS oncogene family 0.118144
MYO10 myosin X 0.118048
ACAP1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 0.117661
MICALL2 MICAL-like 2 0.117562
ADGRE2 adhesion G protein-coupled receptor E2 0.117314
SYNJ2 synaptojanin 2 0.117264
NISCH nischarin 0.117264
ARHGAP18 Rho GTPase activating protein 18 0.117213
MAP2K3 mitogen-activated protein kinase kinase 3 0.117163
STARD13 StAR-related lipid transfer (START) domain containing 13 0.117087
ADAP1 ArfGAP with dual PH domains 1 0.117087
RAB5C RAB5C, member RAS oncogene family 0.116598
FMN1 formin 1 0.116494
PTK6 protein tyrosine kinase 6 0.116308
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3 0.115933
PDE9A phosphodiesterase 9A 0.115466
PSD pleckstrin and Sec7 domain containing 0.115326
SH3KBP1 SH3-domain kinase binding protein 1 0.115015
LIMA1 LIM domain and actin binding 1 0.114757
SH3PXD2B SH3 and PX domains 2B 0.114642
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 0.114436
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.114318
HOXC8 homeobox C8 0.11402
EFNB2 ephrin-B2 0.113869
RAB5B RAB5B, member RAS oncogene family 0.113839
NOX1 NADPH oxidase 1 0.113809
PFN1 profilin 1 0.113749
ARHGAP5 Rho GTPase activating protein 5 0.113749
ARF1 ADP-ribosylation factor 1 0.113534
MYO1E myosin IE 0.11341
ELMO1 engulfment and cell motility 1 0.113162
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein 0.113036
CORO1C coronin, actin binding protein, 1C 0.112909
MYO1C myosin IC 0.112845
VILL villin-like 0.11259
MARCKS myristoylated alanine-rich protein kinase C substrate 0.11233
CCNG2 cyclin G2 0.112233
BMX BMX non-receptor tyrosine kinase 0.112069
TPM1 tropomyosin 1 (alpha) 0.111636
TRAF4 TNF receptor-associated factor 4 0.111398
CSF1 colony stimulating factor 1 (macrophage) 0.111364
THBS1 thrombospondin 1 0.11133
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 0.111296
FYN FYN proto-oncogene, Src family tyrosine kinase 0.111296
HRAS Harvey rat sarcoma viral oncogene homolog 0.111159
PARD3 par-3 family cell polarity regulator 0.111159
RAB5A RAB5A, member RAS oncogene family 0.110848
KRIT1 KRIT1, ankyrin repeat containing 0.110533
NBPF8 neuroblastoma breakpoint family, member 8 0.110463
WAS Wiskott-Aldrich syndrome 0.109961
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.109817
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.109302
LTBP3 latent transforming growth factor beta binding protein 3 0.109266
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.109191
RND2 Rho family GTPase 2 0.10851
AKT2 v-akt murine thymoma viral oncogene homolog 2 0.108433
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.108317
MYO1A myosin IA 0.108317
SH2B3 SH2B adaptor protein 3 0.10797
LTBP2 latent transforming growth factor beta binding protein 2 0.107733
RAB34 RAB34, member RAS oncogene family 0.107575
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 0.107136
GSK3A glycogen synthase kinase 3 alpha 0.106691
SNX5 sorting nexin 5 0.105902