large intestinal inflammation Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description local accumulation of fluid, plasma proteins, and leukocytes in the large intestine (Mammalian Phenotype Ontology, MP_0003304)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0003304
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Genes

112 gene mutations causing the large intestinal inflammation phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ADAM17 ADAM metallopeptidase domain 17
AGR2 anterior gradient 2
AHR aryl hydrocarbon receptor
ANXA1 annexin A1
APOA4 apolipoprotein A-IV
AQP3 aquaporin 3 (Gill blood group)
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
BTK Bruton agammaglobulinemia tyrosine kinase
CCL13 chemokine (C-C motif) ligand 13
CCL3L3 chemokine (C-C motif) ligand 3-like 3
CCR1 chemokine (C-C motif) receptor 1
CCR2 chemokine (C-C motif) receptor 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon
CRLF2 cytokine receptor-like factor 2
CYLD cylindromatosis (turban tumor syndrome)
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DMBT1 deleted in malignant brain tumors 1
EBI3 Epstein-Barr virus induced 3
EREG epiregulin
ERN2 endoplasmic reticulum to nucleus signaling 2
ESR2 estrogen receptor 2 (ER beta)
F2R coagulation factor II (thrombin) receptor
FERMT1 fermitin family member 1
FFAR2 free fatty acid receptor 2
FOXP3 forkhead box P3
FPR2 formyl peptide receptor 2
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GPR15 G protein-coupled receptor 15
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IL10 interleukin 10
IL10RA interleukin 10 receptor, alpha
IL10RB interleukin 10 receptor, beta
IL17A interleukin 17A
IL17F interleukin 17F
IL17RE interleukin 17 receptor E
IL18 interleukin 18
IL2 interleukin 2
IL22 interleukin 22
IL22RA2 interleukin 22 receptor, alpha 2
IL23A interleukin 23, alpha subunit p19
IL2RA interleukin 2 receptor, alpha
IL2RG interleukin 2 receptor, gamma
IL33 interleukin 33
IL6 interleukin 6
IL6ST interleukin 6 signal transducer
ITGB7 integrin, beta 7
JAK3 Janus kinase 3
LTB lymphotoxin beta (TNF superfamily, member 3)
LTBP4 latent transforming growth factor beta binding protein 4
MBTPS1 membrane-bound transcription factor peptidase, site 1
MEP1A meprin A, alpha (PABA peptide hydrolase)
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MST1 macrophage stimulating 1
MUC2 mucin 2, oligomeric mucus/gel-forming
MYD88 myeloid differentiation primary response 88
NFE2L2 nuclear factor, erythroid 2-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBID nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
NLRP12 NLR family, pyrin domain containing 12
NLRP3 NLR family, pyrin domain containing 3
NLRP6 NLR family, pyrin domain containing 6
NOD2 nucleotide-binding oligomerization domain containing 2
NOS2 nitric oxide synthase 2, inducible
NR5A2 nuclear receptor subfamily 5, group A, member 2
PGLYRP1 peptidoglycan recognition protein 1
PGLYRP2 peptidoglycan recognition protein 2
PGLYRP3 peptidoglycan recognition protein 3
PGLYRP4 peptidoglycan recognition protein 4
PIP prolactin-induced protein
PLG plasminogen
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PYCARD PYD and CARD domain containing
RAG1 recombination activating gene 1
RAG2 recombination activating gene 2
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RASGRP4 RAS guanyl releasing protein 4
RC3H1 ring finger and CCCH-type domains 1
RETNLB resistin like beta
RORC RAR-related orphan receptor C
RUNX3 runt-related transcription factor 3
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
SIRT6 sirtuin 6
SMAD3 SMAD family member 3
TBX21 T-box 21
TFF3 trefoil factor 3 (intestinal)
TGFB1 transforming growth factor, beta 1
TICAM1 toll-like receptor adaptor molecule 1
TIGAR TP53 induced glycolysis regulatory phosphatase
TKTL1 transketolase-like 1
TLR2 toll-like receptor 2
TLR5 toll-like receptor 5
TLR9 toll-like receptor 9
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TP53INP1 tumor protein p53 inducible nuclear protein 1
TRPV5 transient receptor potential cation channel, subfamily V, member 5
TSLP thymic stromal lymphopoietin
TSTA3 tissue specific transplantation antigen P35B
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WAS Wiskott-Aldrich syndrome
YIPF6 Yip1 domain family, member 6
ZNF148 zinc finger protein 148