lamellipodium Gene Set

Dataset GO Cellular Component Annotations
Category structural or functional annotations
Type cellular component
Description A thin sheetlike process extended by the leading edge of a crawling fibroblast; contains a dense meshwork of actin filaments. (Gene Ontology, GO_0030027)
External Link http://amigo.geneontology.org/amigo/term/GO:0030027
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Genes

137 proteins localized to the lamellipodium cellular component from the curated GO Cellular Component Annotations dataset.

Symbol Name
ABI1 abl-interactor 1
ABI2 abl-interactor 2
ABI3 ABI family, member 3
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ABLIM1 actin binding LIM protein 1
ABLIM3 actin binding LIM protein family, member 3
ACTR3 ARP3 actin-related protein 3 homolog (yeast)
AIF1 allograft inflammatory factor 1
AJUBA ajuba LIM protein
ALS2 amyotrophic lateral sclerosis 2 (juvenile)
AMOT angiomotin
AMOTL1 angiomotin like 1
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APC adenomatous polyposis coli
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
ARHGAP31 Rho GTPase activating protein 31
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa
BCAR1 breast cancer anti-estrogen resistance 1
BRK1 BRICK1, SCAR/WAVE actin-nucleating complex subunit
CCDC88A coiled-coil domain containing 88A
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK5 cyclin-dependent kinase 5
CIB1 calcium and integrin binding 1 (calmyrin)
CLRN1 clarin 1
CORO1A coronin, actin binding protein, 1A
CORO1B coronin, actin binding protein, 1B
CORO1C coronin, actin binding protein, 1C
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTNNA2 catenin (cadherin-associated protein), alpha 2
CTNNA3 catenin (cadherin-associated protein), alpha 3
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNND1 catenin (cadherin-associated protein), delta 1
CTTN cortactin
CYFIP1 cytoplasmic FMR1 interacting protein 1
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DBNL drebrin-like
DGKZ diacylglycerol kinase, zeta
DPP4 dipeptidyl-peptidase 4
DPYSL3 dihydropyrimidinase-like 3
DYSF dysferlin
ENAH enabled homolog (Drosophila)
EVL Enah/Vasp-like
FAP fibroblast activation protein, alpha
FAT1 FAT atypical cadherin 1
FER fer (fps/fes related) tyrosine kinase
FGD1 FYVE, RhoGEF and PH domain containing 1
FGD2 FYVE, RhoGEF and PH domain containing 2
FGD3 FYVE, RhoGEF and PH domain containing 3
FGD4 FYVE, RhoGEF and PH domain containing 4
FGD5 FYVE, RhoGEF and PH domain containing 5
FGD6 FYVE, RhoGEF and PH domain containing 6
GSN gelsolin
HAX1 HCLS1 associated protein X-1
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1
ILK integrin-linked kinase
INPPL1 inositol polyphosphate phosphatase-like 1
IQGAP2 IQ motif containing GTPase activating protein 2
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB1BP1 integrin beta 1 binding protein 1
ITSN1 intersectin 1 (SH3 domain protein)
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2
KLHL2 kelch-like family member 2
LRRC16A leucine rich repeat containing 16A
MCC mutated in colorectal cancers
MCF2L MCF.2 cell line derived transforming sequence-like
MEFV Mediterranean fever
MYH10 myosin, heavy chain 10, non-muscle
MYLK myosin light chain kinase
MYO10 myosin X
MYO1G myosin IG
MYO9B myosin IXB
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NF2 neurofibromin 2 (merlin)
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies)
NRBP1 nuclear receptor binding protein 1
PALLD palladin, cytoskeletal associated protein
PARVA parvin, alpha
PARVB parvin, beta
PDPN podoplanin
PDXP pyridoxal (pyridoxine, vitamin B6) phosphatase
PHACTR4 phosphatase and actin regulator 4
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PKD2 polycystic kidney disease 2 (autosomal dominant)
PKN2 protein kinase N2
PLCG1 phospholipase C, gamma 1
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5
PLEKHH2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
PLXND1 plexin D1
PODXL podocalyxin-like
PPP1R9B protein phosphatase 1, regulatory subunit 9B
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PTPRM protein tyrosine phosphatase, receptor type, M
PTPRO protein tyrosine phosphatase, receptor type, O
PXN paxillin
RAB13 RAB13, member RAS oncogene family
RAB3IP RAB3A interacting protein
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
RDX radixin
RHOA ras homolog family member A
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
SCRIB scribbled planar cell polarity protein
SCYL3 SCY1-like 3 (S. cerevisiae)
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3
SH3RF1 SH3 domain containing ring finger 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SNX1 sorting nexin 1
SNX2 sorting nexin 2
SPATA13 spermatogenesis associated 13
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2
SSH1 slingshot protein phosphatase 1
STMN2 stathmin 2
STX2 syntaxin 2
STX3 syntaxin 3
STX4 syntaxin 4
SWAP70 SWAP switching B-cell complex 70kDa subunit
TESC tescalcin
TIAM2 T-cell lymphoma invasion and metastasis 2
TRPV4 transient receptor potential cation channel, subfamily V, member 4
TSC1 tuberous sclerosis 1
TWF2 twinfilin actin binding protein 2
VAMP7 vesicle-associated membrane protein 7
VIL1 villin 1
WASF2 WAS protein family, member 2
WASF3 WAS protein family, member 3
WASL Wiskott-Aldrich syndrome-like