lamellipodium Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A thin sheetlike process extended by the leading edge of a crawling fibroblast; contains a dense meshwork of actin filaments. (Gene Ontology, GO_0030027)
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Genes

349 proteins co-occuring with the lamellipodium cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) 2.52309
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 2.51695
CDC42 cell division cycle 42 2.15006
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.96145
CTTN cortactin 1.71497
VASP vasodilator-stimulated phosphoprotein 1.51074
PXN paxillin 1.50453
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.37023
VCL vinculin 1.36637
FN1 fibronectin 1 1.30228
VAV2 vav 2 guanine nucleotide exchange factor 1.2996
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 1.28783
BAIAP2 BAI1-associated protein 2 1.2314
DOCK1 dedicator of cytokinesis 1 1.21894
WAS Wiskott-Aldrich syndrome 1.20601
FSCN1 fascin actin-bundling protein 1 1.17414
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 1.13625
PKN1 protein kinase N1 1.09442
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 1.09442
CRK v-crk avian sarcoma virus CT10 oncogene homolog 1.08933
FSCN3 fascin actin-bundling protein 3, testicular 1.06954
FSCN2 fascin actin-bundling protein 2, retinal 1.05136
EZR ezrin 1.04833
TIAM1 T-cell lymphoma invasion and metastasis 1 1.04481
WASF3 WAS protein family, member 3 1.0408
MCF2 MCF.2 cell line derived transforming sequence 1.02679
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.982932
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.972747
VAV1 vav 1 guanine nucleotide exchange factor 0.917177
PFN1 profilin 1 0.915776
ARHGAP31 Rho GTPase activating protein 31 0.904602
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 0.90089
PLEK pleckstrin 0.890707
MSN moesin 0.884705
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa 0.872266
NEXN nexilin (F actin binding protein) 0.871346
RDX radixin 0.863988
ZYX zyxin 0.857095
ELMO2 engulfment and cell motility 2 0.856635
PFN2 profilin 2 0.846073
LRRC16A leucine rich repeat containing 16A 0.836433
CORO1B coronin, actin binding protein, 1B 0.813487
PFN4 profilin family, member 4 0.810735
INPPL1 inositol polyphosphate phosphatase-like 1 0.796062
LIMK1 LIM domain kinase 1 0.781869
FMN1 formin 1 0.767715
VAV3 vav 3 guanine nucleotide exchange factor 0.75453
WASF2 WAS protein family, member 2 0.747737
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.745477
PARVB parvin, beta 0.727494
WASL Wiskott-Aldrich syndrome-like 0.726599
SWAP70 SWAP switching B-cell complex 70kDa subunit 0.721688
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 0.713238
IQGAP1 IQ motif containing GTPase activating protein 1 0.710579
FRMD1 FERM domain containing 1 0.707039
SPATA13 spermatogenesis associated 13 0.680719
SSH1 slingshot protein phosphatase 1 0.679413
DIAPH3 diaphanous-related formin 3 0.677238
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like 0.666827
MYLK myosin light chain kinase 0.656895
MBTPS1 membrane-bound transcription factor peptidase, site 1 0.637578
GSN gelsolin 0.63544
FHOD1 formin homology 2 domain containing 1 0.629892
ANKRD28 ankyrin repeat domain 28 0.623079
CORO1C coronin, actin binding protein, 1C 0.622654
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.615437
ILK integrin-linked kinase 0.609932
EVL Enah/Vasp-like 0.605284
IQGAP2 IQ motif containing GTPase activating protein 2 0.595593
NCKIPSD NCK interacting protein with SH3 domain 0.592652
DGKZ diacylglycerol kinase, zeta 0.578833
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 0.578833
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 0.572578
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 0.565923
ABI1 abl-interactor 1 0.563847
GMFG glia maturation factor, gamma 0.561358
ACTB actin, beta 0.560943
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4 0.560943
ACTG1 actin gamma 1 0.559285
TESC tescalcin 0.558871
SCYL3 SCY1-like 3 (S. cerevisiae) 0.557629
S1PR1 sphingosine-1-phosphate receptor 1 0.555559
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.542352
EFS embryonal Fyn-associated substrate 0.539883
TPM1 tropomyosin 1 (alpha) 0.534951
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.530438
ARHGAP35 Rho GTPase activating protein 35 0.527569
DNM2 dynamin 2 0.52716
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.52716
MYO9B myosin IXB 0.523067
NCK2 NCK adaptor protein 2 0.52225
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.519798
DOCK5 dedicator of cytokinesis 5 0.517756
ARHGAP18 Rho GTPase activating protein 18 0.516532
STARD13 StAR-related lipid transfer (START) domain containing 13 0.514493
ARHGAP1 Rho GTPase activating protein 1 0.512455
AKIRIN1 akirin 1 0.50757
NCKAP1 NCK-associated protein 1 0.501881
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 0.497015
MYO18A myosin XVIIIA 0.495395
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.490135
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.487711
SEBOX SEBOX homeobox 0.484079
CYFIP2 cytoplasmic FMR1 interacting protein 2 0.483676
ROCK1P1 Rho-associated, coiled-coil containing protein kinase 1 pseudogene 1 0.483676
CD44 CD44 molecule (Indian blood group) 0.483273
NCK1 NCK adaptor protein 1 0.479647
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6 0.477636
WWC2 WW and C2 domain containing 2 0.475625
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7 0.474822
TJP1 tight junction protein 1 0.472813
CD302 CD302 molecule 0.472412
SYK spleen tyrosine kinase 0.470406
CD82 CD82 molecule 0.470406
CTNND1 catenin (cadherin-associated protein), delta 1 0.468802
PLAU plasminogen activator, urokinase 0.4676
EGFR epidermal growth factor receptor 0.465198
CFL1 cofilin 1 (non-muscle) 0.454816
PLCG1 phospholipase C, gamma 1 0.453223
TMEM97 transmembrane protein 97 0.449245
RHOB ras homolog family member B 0.446069
FYB FYN binding protein 0.444482
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 0.444482
NHSL1 NHS-like 1 0.434196
NHSL2 NHS-like 2 0.434196
MAPK4 mitogen-activated protein kinase 4 0.433407
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.429465
TIAM2 T-cell lymphoma invasion and metastasis 2 0.426318
SASH1 SAM and SH3 domain containing 1 0.425138
MET MET proto-oncogene, receptor tyrosine kinase 0.421604
MARCKS myristoylated alanine-rich protein kinase C substrate 0.416511
FAT1 FAT atypical cadherin 1 0.414555
PLEKHH2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 0.413773
NGF nerve growth factor (beta polypeptide) 0.41143
ADGRF5 adhesion G protein-coupled receptor F5 0.411039
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.410649
GDNF glial cell derived neurotrophic factor 0.409869
WASF1 WAS protein family, member 1 0.409869
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.409089
EFHD2 EF-hand domain family, member D2 0.409089
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.407529
ARF6 ADP-ribosylation factor 6 0.40675
NRP1 neuropilin 1 0.397423
COMMD5 COMM domain containing 5 0.396648
TRIP10 thyroid hormone receptor interactor 10 0.395873
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.394323
BCAR3 breast cancer anti-estrogen resistance 3 0.393936
BCAR1 breast cancer anti-estrogen resistance 1 0.390841
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like 0.389296
KPTN kaptin (actin binding protein) 0.38428
FLNA filamin A, alpha 0.383895
ITGB1BP1 integrin beta 1 binding protein 1 0.383895
RLTPR RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing 0.381969
DIAPH1 diaphanous-related formin 1 0.376202
PALLD palladin, cytoskeletal associated protein 0.37505
EPS8 epidermal growth factor receptor pathway substrate 8 0.373516
MMP9 matrix metallopeptidase 9 0.370833
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1 0.370067
CSF1 colony stimulating factor 1 (macrophage) 0.369301
IGF1 insulin-like growth factor 1 (somatomedin C) 0.367388
FAM215A family with sequence similarity 215, member A (non-protein coding) 0.366623
BAIAP2L1 BAI1-associated protein 2-like 1 0.363567
VAMP3 vesicle-associated membrane protein 3 0.361659
GRB2 growth factor receptor-bound protein 2 0.361277
PLS3 plastin 3 0.352142
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase 0.351002
JUN jun proto-oncogene 0.34645
MIR197 microRNA 197 0.346071
LAMB2 laminin, beta 2 (laminin S) 0.345692
NEBL nebulette 0.345692
MYO10 myosin X 0.344935
PTK2 protein tyrosine kinase 2 0.344556
RALGDS ral guanine nucleotide dissociation stimulator 0.343421
PLXNB1 plexin B1 0.341151
RND1 Rho family GTPase 1 0.336996
CDH5 cadherin 5, type 2 (vascular endothelium) 0.330589
CHN1 chimerin 1 0.327205
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C) 0.325327
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.32345
ITGB6 integrin, beta 6 0.32345
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.32195
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 0.32195
ARHGEF25 Rho guanine nucleotide exchange factor (GEF) 25 0.321201
GRB7 growth factor receptor-bound protein 7 0.319328
ERBB2 erb-b2 receptor tyrosine kinase 2 0.318205
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) 0.317456
HCLS1 hematopoietic cell-specific Lyn substrate 1 0.316708
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.314465
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 0.312224
ITGB5 integrin, beta 5 0.310358
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16 0.308494
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3 0.308494
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.308122
ACTA1 actin, alpha 1, skeletal muscle 0.307377
MSH6 mutS homolog 6 0.306632
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.304771
NPHS1 nephrosis 1, congenital, Finnish type (nephrin) 0.30254
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2 0.302168
SRF serum response factor (c-fos serum response element-binding transcription factor) 0.301797
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 0.301425
AMPH amphiphysin 0.300682
WDR44 WD repeat domain 44 0.298826
VEGFA vascular endothelial growth factor A 0.296972
F2R coagulation factor II (thrombin) receptor 0.296972
INPP5A inositol polyphosphate-5-phosphatase, 40kDa 0.292157
MMP2 matrix metallopeptidase 2 0.291047
RIN2 Ras and Rab interactor 2 0.289938
LMCD1 LIM and cysteine-rich domains 1 0.289938
MAPK8 mitogen-activated protein kinase 8 0.288091
SH2D5 SH2 domain containing 5 0.287352
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26 0.283663
PI3 peptidase inhibitor 3, skin-derived 0.282558
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 0.279612
CDKN2A cyclin-dependent kinase inhibitor 2A 0.277774
PHLDB1 pleckstrin homology-like domain, family B, member 1 0.277038
MTSS1 metastasis suppressor 1 0.275202
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 0.273
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.272267
PLD2 phospholipase D2 0.270434
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.269701
FYN FYN proto-oncogene, Src family tyrosine kinase 0.268603
CD2AP CD2-associated protein 0.266774
CSK c-src tyrosine kinase 0.26385
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.26385
GAS6 growth arrest-specific 6 0.262755
TRPV4 transient receptor potential cation channel, subfamily V, member 4 0.260202
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial) 0.260202
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.258745
EFNB3 ephrin-B3 0.25547
RET ret proto-oncogene 0.252202
PHACTR4 phosphatase and actin regulator 4 0.251839
NRG4 neuregulin 4 0.251476
SMPX small muscle protein, X-linked 0.250389
CCR10 chemokine (C-C motif) receptor 10 0.249664
USE1 unconventional SNARE in the ER 1 homolog (S. cerevisiae) 0.24894
PLEK2 pleckstrin 2 0.246407
ICAM1 intercellular adhesion molecule 1 0.246046
LGALS8 lectin, galactoside-binding, soluble, 8 0.244601
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.242797
MEGF10 multiple EGF-like-domains 10 0.242797
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.242076
DOCK2 dedicator of cytokinesis 2 0.240636
CCDC88A coiled-coil domain containing 88A 0.239916
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 0.238478
DVL3 dishevelled segment polarity protein 3 0.238478
DBNL drebrin-like 0.23776
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa 0.236683
RHOQ ras homolog family member Q 0.236324
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.235966
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.235966
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.235607
MCF2L MCF.2 cell line derived transforming sequence-like 0.234891
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.234533
FGD3 FYVE, RhoGEF and PH domain containing 3 0.233817
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 0.232744
MOB1B MOB kinase activator 1B 0.231315
RHOBTB1 Rho-related BTB domain containing 1 0.231315
ITGB4 integrin, beta 4 0.229176
FGD4 FYVE, RhoGEF and PH domain containing 4 0.228108
EIF5A2 eukaryotic translation initiation factor 5A2 0.227752
CCDC88C coiled-coil domain containing 88C 0.226331
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 0.222083
ITGB7 integrin, beta 7 0.219969
NAV3 neuron navigator 3 0.219617
WNT5A wingless-type MMTV integration site family, member 5A 0.219265
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 0.219265
ITGB8 integrin, beta 8 0.219265
TGFB1 transforming growth factor, beta 1 0.218914
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.218563
DPYSL3 dihydropyrimidinase-like 3 0.218563
IGSF5 immunoglobulin superfamily, member 5 0.218563
TSSK6 testis-specific serine kinase 6 0.214714
FLNB filamin B, beta 0.214714
PODXL podocalyxin-like 0.212974
HDAC6 histone deacetylase 6 0.21228
DGKG diacylglycerol kinase, gamma 90kDa 0.21124
HRAS Harvey rat sarcoma viral oncogene homolog 0.210203
TRIM2 tripartite motif containing 2 0.210203
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.210203
PTPRD protein tyrosine phosphatase, receptor type, D 0.208825
CPVL carboxypeptidase, vitellogenic-like 0.208481
FAT3 FAT atypical cadherin 3 0.203361
LGALS3 lectin, galactoside-binding, soluble, 3 0.202009
PKD1 polycystic kidney disease 1 (autosomal dominant) 0.201335
CXCR2 chemokine (C-X-C motif) receptor 2 0.198658
VPS26B vacuolar protein sorting 26 homolog B (S. pombe) 0.19733
CLASP1 cytoplasmic linker associated protein 1 0.194045
BIN3 bridging integrator 3 0.193719
FPR1 formyl peptide receptor 1 0.19307
PARD6A par-6 family cell polarity regulator alpha 0.192423
ICOS inducible T-cell co-stimulator 0.191456
AJUBA ajuba LIM protein 0.190814
EFNB2 ephrin-B2 0.189539
LYPD3 LY6/PLAUR domain containing 3 0.189539
TMOD2 tropomodulin 2 (neuronal) 0.188905
MYH2 myosin, heavy chain 2, skeletal muscle, adult 0.18859
MPDZ multiple PDZ domain protein 0.18702
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.186397
PIAS3 protein inhibitor of activated STAT, 3 0.18516
EPHA2 EPH receptor A2 0.18516
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 0.183025
GAS7 growth arrest-specific 7 0.181823
DGKA diacylglycerol kinase, alpha 80kDa 0.181823
FMNL3 formin-like 3 0.181823
PRKD1 protein kinase D1 0.181524
SPHK1 sphingosine kinase 1 0.179752
INSR insulin receptor 0.179752
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived) 0.179459
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.179167
TRIM44 tripartite motif containing 44 0.178877
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 0.177154
RHOF ras homolog family member F (in filopodia) 0.176587
RSU1 Ras suppressor protein 1 0.176587
GRP gastrin-releasing peptide 0.176305
EPHB2 EPH receptor B2 0.174635
STX4 syntaxin 4 0.174361
CCR4 chemokine (C-C motif) receptor 4 0.173543
ALKBH2 alkB, alkylation repair homolog 2 (E. coli) 0.173003
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.17141
CAPN6 calpain 6 0.17141
MAZ MYC-associated zinc finger protein (purine-binding transcription factor) 0.171149
AQP9 aquaporin 9 0.170888
KNG1 kininogen 1 0.169859
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.168349
FGD1 FYVE, RhoGEF and PH domain containing 1 0.168349
KIRREL kin of IRRE like (Drosophila) 0.167125
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F 0.166884
DACT2 dishevelled-binding antagonist of beta-catenin 2 0.165697
FXYD5 FXYD domain containing ion transport regulator 5 0.165463
CXCL12 chemokine (C-X-C motif) ligand 12 0.163865
GPR50 G protein-coupled receptor 50 0.163641
MYO5A myosin VA (heavy chain 12, myoxin) 0.162117
LIMK2 LIM domain kinase 2 0.161275
MOB1A MOB kinase activator 1A 0.160863
MAGED1 melanoma antigen family D1 0.160456
CRIP2 cysteine-rich protein 2 0.160254
MYH9 myosin, heavy chain 9, non-muscle 0.159658
LCP1 lymphocyte cytosolic protein 1 (L-plastin) 0.159462
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.159462
VAMP4 vesicle-associated membrane protein 4 0.159462
RBPJL recombination signal binding protein for immunoglobulin kappa J region-like 0.158315
AQP1 aquaporin 1 (Colton blood group) 0.158129
FGF7 fibroblast growth factor 7 0.158129
CCND1 cyclin D1 0.15776
DGKB diacylglycerol kinase, beta 90kDa 0.157578
PTK7 protein tyrosine kinase 7 (inactive) 0.157578
DOCK8 dedicator of cytokinesis 8 0.157039
RCC2 regulator of chromosome condensation 2 0.157039
SGMS2 sphingomyelin synthase 2 0.156688