lamellipodium Gene Set

Dataset COMPARTMENTS Curated Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A thin sheetlike process extended by the leading edge of a crawling fibroblast; contains a dense meshwork of actin filaments. (Gene Ontology, GO_0030027)
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Genes

132 proteins localized to the lamellipodium cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
NME1-NME2 NME1-NME2 readthrough 0.663342
SSH1 slingshot protein phosphatase 1 0.663342
DGKZ diacylglycerol kinase, zeta 0.663342
PKN2 protein kinase N2 0.663342
FAP fibroblast activation protein, alpha 0.663342
TSC1 tuberous sclerosis 1 0.663342
PTPRM protein tyrosine phosphatase, receptor type, M 0.663342
CIB1 calcium and integrin binding 1 (calmyrin) 0.663342
PLEKHH2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 0.663342
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.663342
WASH1 WAS protein family homolog 1 0.663342
SCYL3 SCY1-like 3 (S. cerevisiae) 0.663342
PODXL podocalyxin-like 0.663342
PLEK2 pleckstrin 2 0.663342
VIL1 villin 1 0.663342
MYLK myosin light chain kinase 0.663342
ITGB1BP1 integrin beta 1 binding protein 1 0.663342
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.663342
SNAP25 synaptosomal-associated protein, 25kDa 0.663342
NME2 NME/NM23 nucleoside diphosphate kinase 2 0.663342
WASF2 WAS protein family, member 2 0.663342
CORO1A coronin, actin binding protein, 1A 0.663342
PPP1R9B protein phosphatase 1, regulatory subunit 9B 0.663342
SLC39A6 solute carrier family 39 (zinc transporter), member 6 0.663342
PLCG1 phospholipase C, gamma 1 0.663342
INPPL1 inositol polyphosphate phosphatase-like 1 0.663342
SH3RF1 SH3 domain containing ring finger 1 0.663342
CCDC88A coiled-coil domain containing 88A 0.663342
MCC mutated in colorectal cancers 0.663342
RAB3IP RAB3A interacting protein 0.663342
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.663342
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) 0.663342
APC adenomatous polyposis coli 0.663342
SWAP70 SWAP switching B-cell complex 70kDa subunit 0.663342
PARVB parvin, beta 0.663342
EPHA2 EPH receptor A2 0.663342
AMOT angiomotin 0.663342
VASP vasodilator-stimulated phosphoprotein 0.663342
SCRIB scribbled planar cell polarity protein 0.663342
DPP4 dipeptidyl-peptidase 4 0.663342
STMN2 stathmin 2 0.663342
ABLIM3 actin binding LIM protein family, member 3 0.663342
ABLIM1 actin binding LIM protein 1 0.663342
SPATA13 spermatogenesis associated 13 0.663342
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 0.663342
TESC tescalcin 0.663342
ABI1 abl-interactor 1 0.663342
ABI3 ABI family, member 3 0.663342
ABI2 abl-interactor 2 0.663342
ITGAV integrin, alpha V 0.663342
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.663342
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.663342
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.663342
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.663342
ITSN1 intersectin 1 (SH3 domain protein) 0.663342
PTK2B protein tyrosine kinase 2 beta 0.663342
CLRN1 clarin 1 0.663342
SYNE1 spectrin repeat containing, nuclear envelope 1 0.663342
SYNE2 spectrin repeat containing, nuclear envelope 2 0.663342
MEFV Mediterranean fever 0.663342
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 0.663342
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 0.663342
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.663342
ANTXR1 anthrax toxin receptor 1 0.663342
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3 0.663342
PALLD palladin, cytoskeletal associated protein 0.663342
APC2 adenomatosis polyposis coli 2 0.237908
ALS2 amyotrophic lateral sclerosis 2 (juvenile) 0.237908
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 0.237908
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.237908
FGD3 FYVE, RhoGEF and PH domain containing 3 0.237908
FGD2 FYVE, RhoGEF and PH domain containing 2 0.237908
FGD1 FYVE, RhoGEF and PH domain containing 1 0.237908
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 0.237908
FGD6 FYVE, RhoGEF and PH domain containing 6 0.237908
FGD4 FYVE, RhoGEF and PH domain containing 4 0.237908
PTPRO protein tyrosine phosphatase, receptor type, O 0.237908
FGD5 FYVE, RhoGEF and PH domain containing 5 0.237908
LRRC16A leucine rich repeat containing 16A 0.237908
RAB13 RAB13, member RAS oncogene family 0.237908
CORO1B coronin, actin binding protein, 1B 0.237908
DBNL drebrin-like 0.237908
DPYSL3 dihydropyrimidinase-like 3 0.237908
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.237908
CTTN cortactin 0.237908
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.237908
PXN paxillin 0.237908
PKD2 polycystic kidney disease 2 (autosomal dominant) 0.237908
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 0.237908
PLXND1 plexin D1 0.237908
PDPN podoplanin 0.237908
RHOA ras homolog family member A 0.237908
PHACTR4 phosphatase and actin regulator 4 0.237908
CYFIP1 cytoplasmic FMR1 interacting protein 1 0.237908
AIF1 allograft inflammatory factor 1 0.237908
ARPIN actin-related protein 2/3 complex inhibitor 0.237908
EVL Enah/Vasp-like 0.237908
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 0.237908
TRPV4 transient receptor potential cation channel, subfamily V, member 4 0.098109
HAX1 HCLS1 associated protein X-1 0.098109
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.098109
TWF2 twinfilin actin binding protein 2 0.098109
GSN gelsolin 0.03318
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa 0.03318
PARVA parvin, alpha 0.03318
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.03318
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.03318
FAT1 FAT atypical cadherin 1 0.03318
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.03318
AMOTL1 angiomotin like 1 0.03318
DYSF dysferlin 0.03318
ILK integrin-linked kinase 0.03318
CDK5 cyclin-dependent kinase 5 0.03318
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.03318
NF2 neurofibromin 2 (merlin) 0.03318
WASF1 WAS protein family, member 1 0.03318
ARHGAP31 Rho GTPase activating protein 31 0.03318
AJUBA ajuba LIM protein 0.03318
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.03318
PTK2 protein tyrosine kinase 2 0.03318
MYO9B myosin IXB 0.03318
ENAH enabled homolog (Drosophila) 0.03318
BCAR1 breast cancer anti-estrogen resistance 1 0.03318
CFL1 cofilin 1 (non-muscle) 0.03318
MCF2L MCF.2 cell line derived transforming sequence-like 0.03318
CAPZB capping protein (actin filament) muscle Z-line, beta 0.03318
NCKAP1 NCK-associated protein 1 0.03318
CTNND1 catenin (cadherin-associated protein), delta 1 0.03318
RDX radixin 0.03318
WASL Wiskott-Aldrich syndrome-like 0.03318
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 0.03318
WASF3 WAS protein family, member 3 0.03318