karakoline-3741 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the karakoline-3741 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADCY2 adenylate cyclase 2 (brain)
ADGRL3 adhesion G protein-coupled receptor L3
ANXA10 annexin A10
APOH apolipoprotein H (beta-2-glycoprotein I)
ARC activity-regulated cytoskeleton-associated protein
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ARMC9 armadillo repeat containing 9
ARSE arylsulfatase E (chondrodysplasia punctata 1)
ATF5 activating transcription factor 5
ATF6B activating transcription factor 6 beta
ATG10 autophagy related 10
ATP10B ATPase, class V, type 10B
BCL2L10 BCL2-like 10 (apoptosis facilitator)
BHLHB9 basic helix-loop-helix domain containing, class B, 9
C14ORF79 chromosome 14 open reading frame 79
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
C2ORF72 chromosome 2 open reading frame 72
CARF calcium responsive transcription factor
CCDC134 coiled-coil domain containing 134
CCP110 centriolar coiled coil protein 110kDa
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle)
CLDN8 claudin 8
CREB3L1 cAMP responsive element binding protein 3-like 1
DKFZP434C153 DKFZP434C153 protein
DUSP2 dual specificity phosphatase 2
EDRF1 erythroid differentiation regulatory factor 1
EGR1 early growth response 1
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FGF2 fibroblast growth factor 2 (basic)
FGF22 fibroblast growth factor 22
FHL3 four and a half LIM domains 3
GLYAT glycine-N-acyltransferase
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GZMK granzyme K (granzyme 3; tryptase II)
HEG1 heart development protein with EGF-like domains 1
HIST1H3F histone cluster 1, H3f
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
IGF1R insulin-like growth factor 1 receptor
IL1RN interleukin 1 receptor antagonist
IL22RA1 interleukin 22 receptor, alpha 1
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KDM4C lysine (K)-specific demethylase 4C
KLK10 kallikrein-related peptidase 10
KRT17 keratin 17, type I
MAPK11 mitogen-activated protein kinase 11
MEGF8 multiple EGF-like-domains 8
MMP10 matrix metallopeptidase 10
MPZ myelin protein zero
MRC2 mannose receptor, C type 2
MST1 macrophage stimulating 1
NAV3 neuron navigator 3
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
NR1H4 nuclear receptor subfamily 1, group H, member 4
NTF3 neurotrophin 3
NUP214 nucleoporin 214kDa
PAX8 paired box 8
PDE12 phosphodiesterase 12
PDE2A phosphodiesterase 2A, cGMP-stimulated
PECAM1 platelet/endothelial cell adhesion molecule 1
PGLYRP1 peptidoglycan recognition protein 1
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PLK4 polo-like kinase 4
PLXND1 plexin D1
POU2F2 POU class 2 homeobox 2
PRKG1 protein kinase, cGMP-dependent, type I
PRODH proline dehydrogenase (oxidase) 1
PTCRA pre T-cell antigen receptor alpha
R3HCC1L R3H domain and coiled-coil containing 1-like
RABEP1 rabaptin, RAB GTPase binding effector protein 1
RABEP2 rabaptin, RAB GTPase binding effector protein 2
RAD51 RAD51 recombinase
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RASL11B RAS-like, family 11, member B
RBMS3 RNA binding motif, single stranded interacting protein 3
RECQL5 RecQ protein-like 5
RNF17 ring finger protein 17
RNF6 ring finger protein (C3H2C3 type) 6
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SKIL SKI-like proto-oncogene
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SOX10 SRY (sex determining region Y)-box 10
SRSF5 serine/arginine-rich splicing factor 5
STAB2 stabilin 2
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
TBX6 T-box 6
TJP3 tight junction protein 3
TNS1 tensin 1
TNXB tenascin XB
TSPAN9 tetraspanin 9
UBE2I ubiquitin-conjugating enzyme E2I
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
ZBTB6 zinc finger and BTB domain containing 6
ZFP64 ZFP64 zinc finger protein
ZNF345 zinc finger protein 345
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ADAM15 ADAM metallopeptidase domain 15
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12
ADGRB2 adhesion G protein-coupled receptor B2
ADTRP androgen-dependent TFPI-regulating protein
AIPL1 aryl hydrocarbon receptor interacting protein-like 1
AK5 adenylate kinase 5
AMN amnion associated transmembrane protein
ANKH ANKH inorganic pyrophosphate transport regulator
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BDKRB1 bradykinin receptor B1
C11ORF21 chromosome 11 open reading frame 21
C1ORF54 chromosome 1 open reading frame 54
C1QTNF3 C1q and tumor necrosis factor related protein 3
CCDC7 coiled-coil domain containing 7
CDH19 cadherin 19, type 2
CEP41 centrosomal protein 41kDa
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CISH cytokine inducible SH2-containing protein
CLDN1 claudin 1
CORT cortistatin
CUZD1 CUB and zona pellucida-like domains 1
CXORF21 chromosome X open reading frame 21
CYB5R2 cytochrome b5 reductase 2
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
ELSPBP1 epididymal sperm binding protein 1
ERN2 endoplasmic reticulum to nucleus signaling 2
F13A1 coagulation factor XIII, A1 polypeptide
FAM120C family with sequence similarity 120C
FAM46C family with sequence similarity 46, member C
FBXL7 F-box and leucine-rich repeat protein 7
FBXO31 F-box protein 31
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FRS2 fibroblast growth factor receptor substrate 2
GBP2 guanylate binding protein 2, interferon-inducible
GMPR guanosine monophosphate reductase
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
HAO2 hydroxyacid oxidase 2 (long chain)
HIST1H2BN histone cluster 1, H2bn
HIST1H4F histone cluster 1, H4f
HOMER2 homer scaffolding protein 2
HOXA4 homeobox A4
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
HSPA1L heat shock 70kDa protein 1-like
IFNA17 interferon, alpha 17
INPP5J inositol polyphosphate-5-phosphatase J
IQCC IQ motif containing C
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIAA1456 KIAA1456
LMTK2 lemur tyrosine kinase 2
LRP5L low density lipoprotein receptor-related protein 5-like
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MFI2 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MRAS muscle RAS oncogene homolog
MYOZ3 myozenin 3
NARFL nuclear prelamin A recognition factor-like
NELL2 NEL-like 2 (chicken)
NPHP1 nephronophthisis 1 (juvenile)
NR2E3 nuclear receptor subfamily 2, group E, member 3
OAZ3 ornithine decarboxylase antizyme 3
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)
PARD6A par-6 family cell polarity regulator alpha
PC pyruvate carboxylase
PER3 period circadian clock 3
PGLYRP4 peptidoglycan recognition protein 4
PODNL1 podocan-like 1
PRDM1 PR domain containing 1, with ZNF domain
PTPRS protein tyrosine phosphatase, receptor type, S
RLN1 relaxin 1
RPL10L ribosomal protein L10-like
SCD5 stearoyl-CoA desaturase 5
SCUBE3 signal peptide, CUB domain, EGF-like 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter), member 2
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TBC1D2 TBC1 domain family, member 2
TCP10 t-complex 10
TESPA1 thymocyte expressed, positive selection associated 1
TEX15 testis expressed 15
TIGD6 tigger transposable element derived 6
TMEM74B transmembrane protein 74B
TRAC T cell receptor alpha constant
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TSNAXIP1 translin-associated factor X interacting protein 1
USP20 ubiquitin specific peptidase 20
VGF VGF nerve growth factor inducible
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZNF219 zinc finger protein 219
ZNF446 zinc finger protein 446
ZNF480 zinc finger protein 480
ZNF528 zinc finger protein 528
ZNF573 zinc finger protein 573
ZNRD1-AS1 ZNRD1 antisense RNA 1