jak-stat cascade Gene Set

Dataset GO Biological Process Annotations
Category structural or functional annotations
Type biological process
Description Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The JAK-STAT cascade begins with activation of STAT proteins by members of the JAK family of tyrosine kinases, proceeds through dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins. (Gene Ontology, GO_0007259)
External Link http://amigo.geneontology.org/amigo/term/GO:0007259
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Genes

44 genes participating in the jak-stat cascade biological process from the curated GO Biological Process Annotations dataset.

Symbol Name
ADAM17 ADAM metallopeptidase domain 17
CCL2 chemokine (C-C motif) ligand 2
CCR2 chemokine (C-C motif) receptor 2
CISH cytokine inducible SH2-containing protein
CLCF1 cardiotrophin-like cytokine factor 1
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen)
CTR9 CTR9, Paf1/RNA polymerase II complex component
FGFR3 fibroblast growth factor receptor 3
GH1 growth hormone 1
GH2 growth hormone 2
GHR growth hormone receptor
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNAR2 interferon (alpha, beta and omega) receptor 2
IFNL1 interferon, lambda 1
IFNL2 interferon, lambda 2
IFNL3 interferon, lambda 3
IL31RA interleukin 31 receptor A
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
JAK2 Janus kinase 2
JAK3 Janus kinase 3
LYN LYN proto-oncogene, Src family tyrosine kinase
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
NMI N-myc (and STAT) interactor
PIAS1 protein inhibitor of activated STAT, 1
PKD1 polycystic kidney disease 1 (autosomal dominant)
PKD2 polycystic kidney disease 2 (autosomal dominant)
PRL prolactin
PRLR prolactin receptor
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN6 protein tyrosine phosphatase, non-receptor type 6
SOCS1 suppressor of cytokine signaling 1
SOCS2 suppressor of cytokine signaling 2
SOCS3 suppressor of cytokine signaling 3
SOCS5 suppressor of cytokine signaling 5
SOCS6 suppressor of cytokine signaling 6
STAMBP STAM binding protein
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT2 signal transducer and activator of transcription 2, 113kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT4 signal transducer and activator of transcription 4
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B