jak stat signaling pathway Gene Set

Dataset KEGG Pathways
Category structural or functional annotations
Type pathway
Description The Jak-Stat pathway is a main intracellular cascade initiated primarily in response to cytokine and also other ligand signaling. Four Janus kinases (Jak) and seven signal transducers and activators of transcription (Stat) families of proteins mediate the action of almost 40 cytokine receptors, including the receptor for leptin. Combinations between four Jak(s) and seven Stat(s) shape the outcome of ligand triggered signaling through the various receptors. (Pathway Ontology, PW_0000209)
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Genes

148 proteins participating in the jak stat signaling pathway pathway from the KEGG Pathways dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
BCL2L1 BCL2-like 1
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBLC Cbl proto-oncogene C, E3 ubiquitin protein ligase
CCND1 cyclin D1
CCND2 cyclin D2
CCND3 cyclin D3
CISH cytokine inducible SH2-containing protein
CLCF1 cardiotrophin-like cytokine factor 1
CNTF ciliary neurotrophic factor
CNTFR ciliary neurotrophic factor receptor
CREBBP CREB binding protein
CRLF2 cytokine receptor-like factor 2
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CSF3 colony stimulating factor 3 (granulocyte)
CSF3R colony stimulating factor 3 receptor (granulocyte)
CTF1 cardiotrophin 1
EP300 E1A binding protein p300
EPO erythropoietin
EPOR erythropoietin receptor
GH1 growth hormone 1
GH2 growth hormone 2
GHR growth hormone receptor
GRB2 growth factor receptor-bound protein 2
IFNA1 interferon, alpha 1
IFNA10 interferon, alpha 10
IFNA13 interferon, alpha 13
IFNA14 interferon, alpha 14
IFNA16 interferon, alpha 16
IFNA17 interferon, alpha 17
IFNA2 interferon, alpha 2
IFNA21 interferon, alpha 21
IFNA4 interferon, alpha 4
IFNA5 interferon, alpha 5
IFNA6 interferon, alpha 6
IFNA7 interferon, alpha 7
IFNA8 interferon, alpha 8
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNAR2 interferon (alpha, beta and omega) receptor 2
IFNB1 interferon, beta 1, fibroblast
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IFNK interferon, kappa
IFNW1 interferon, omega 1
IL10 interleukin 10
IL10RA interleukin 10 receptor, alpha
IL10RB interleukin 10 receptor, beta
IL11 interleukin 11
IL11RA interleukin 11 receptor, alpha
IL12A interleukin 12A
IL12B interleukin 12B
IL12RB1 interleukin 12 receptor, beta 1
IL12RB2 interleukin 12 receptor, beta 2
IL13 interleukin 13
IL13RA1 interleukin 13 receptor, alpha 1
IL13RA2 interleukin 13 receptor, alpha 2
IL15 interleukin 15
IL15RA interleukin 15 receptor, alpha
IL19 interleukin 19
IL2 interleukin 2
IL20 interleukin 20
IL20RA interleukin 20 receptor, alpha
IL21 interleukin 21
IL21R interleukin 21 receptor
IL22 interleukin 22
IL22RA1 interleukin 22 receptor, alpha 1
IL22RA2 interleukin 22 receptor, alpha 2
IL23A interleukin 23, alpha subunit p19
IL23R interleukin 23 receptor
IL24 interleukin 24
IL26 interleukin 26
IL2RA interleukin 2 receptor, alpha
IL2RB interleukin 2 receptor, beta
IL2RG interleukin 2 receptor, gamma
IL3 interleukin 3
IL3RA interleukin 3 receptor, alpha (low affinity)
IL4 interleukin 4
IL4R interleukin 4 receptor
IL5 interleukin 5
IL5RA interleukin 5 receptor, alpha
IL6 interleukin 6
IL6R interleukin 6 receptor
IL6ST interleukin 6 signal transducer
IL7 interleukin 7
IL7R interleukin 7 receptor
IL9 interleukin 9
IL9R interleukin 9 receptor
IRF9 interferon regulatory factor 9
JAK1 Janus kinase 1
JAK2 Janus kinase 2
JAK3 Janus kinase 3
LEP leptin
LEPR leptin receptor
LIF leukemia inhibitory factor
LIFR leukemia inhibitory factor receptor alpha
MPL MPL proto-oncogene, thrombopoietin receptor
MYC v-myc avian myelocytomatosis viral oncogene homolog
OSM oncostatin M
OSMR oncostatin M receptor
PIAS1 protein inhibitor of activated STAT, 1
PIAS2 protein inhibitor of activated STAT, 2
PIAS3 protein inhibitor of activated STAT, 3
PIAS4 protein inhibitor of activated STAT, 4
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PRL prolactin
PRLR prolactin receptor
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN6 protein tyrosine phosphatase, non-receptor type 6
SOCS1 suppressor of cytokine signaling 1
SOCS2 suppressor of cytokine signaling 2
SOCS3 suppressor of cytokine signaling 3
SOCS4 suppressor of cytokine signaling 4
SOCS5 suppressor of cytokine signaling 5
SOCS7 suppressor of cytokine signaling 7
SOS1 son of sevenless homolog 1 (Drosophila)
SOS2 son of sevenless homolog 2 (Drosophila)
SPRED1 sprouty-related, EVH1 domain containing 1
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
SPRY3 sprouty homolog 3 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT2 signal transducer and activator of transcription 2, 113kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT4 signal transducer and activator of transcription 4
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TPO thyroid peroxidase
TSLP thymic stromal lymphopoietin
TYK2 tyrosine kinase 2