ivermectin-7206 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the ivermectin-7206 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ACE angiotensin I converting enzyme
ALOX12 arachidonate 12-lipoxygenase
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP9A ATPase, class II, type 9A
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BIRC3 baculoviral IAP repeat containing 3
C1RL complement component 1, r subcomponent-like
CASP8 caspase 8, apoptosis-related cysteine peptidase
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CSHL1 chorionic somatomammotropin hormone-like 1
CTC1 CTS telomere maintenance complex component 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DIO2 deiodinase, iodothyronine, type II
DLC1 DLC1 Rho GTPase activating protein
DPYS dihydropyrimidinase
EGR3 early growth response 3
EMID1 EMI domain containing 1
ETV7 ets variant 7
FBXL7 F-box and leucine-rich repeat protein 7
FGFR2 fibroblast growth factor receptor 2
FHL1 four and a half LIM domains 1
FHL2 four and a half LIM domains 2
FRMPD1 FERM and PDZ domain containing 1
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GTPBP2 GTP binding protein 2
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HOXC8 homeobox C8
HYMAI hydatidiform mole associated and imprinted (non-protein coding)
IFI6 interferon, alpha-inducible protein 6
IFIT5 interferon-induced protein with tetratricopeptide repeats 5
IGFBP5 insulin-like growth factor binding protein 5
IGFBP6 insulin-like growth factor binding protein 6
IL24 interleukin 24
INHBE inhibin, beta E
ISG20 interferon stimulated exonuclease gene 20kDa
KDM4C lysine (K)-specific demethylase 4C
KRT6B keratin 6B, type II
L3MBTL1 l(3)mbt-like 1 (Drosophila)
LIF leukemia inhibitory factor
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP3K9 mitogen-activated protein kinase kinase kinase 9
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NPFF neuropeptide FF-amide peptide precursor
NR2E3 nuclear receptor subfamily 2, group E, member 3
NUP188 nucleoporin 188kDa
NUP54 nucleoporin 54kDa
NUPR1 nuclear protein, transcriptional regulator, 1
OCM2 oncomodulin 2
PAIP2B poly(A) binding protein interacting protein 2B
PCDHGA10 protocadherin gamma subfamily A, 10
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PODNL1 podocan-like 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RFTN1 raftlin, lipid raft linker 1
RNF170 ring finger protein 170
RPL7 ribosomal protein L7
RYR1 ryanodine receptor 1 (skeletal)
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SH3D21 SH3 domain containing 21
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
SMC1A structural maintenance of chromosomes 1A
SPINK1 serine peptidase inhibitor, Kazal type 1
SRSF5 serine/arginine-rich splicing factor 5
STAG3L4 stromal antigen 3-like 4 (pseudogene)
SYBU syntabulin (syntaxin-interacting)
SYNPO synaptopodin
TAT tyrosine aminotransferase
TDRD3 tudor domain containing 3
THBS1 thrombospondin 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLR2 toll-like receptor 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TTC33 tetratricopeptide repeat domain 33
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
WDTC1 WD and tetratricopeptide repeats 1
XYLB xylulokinase homolog (H. influenzae)
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ADRA2C adrenoceptor alpha 2C
AHDC1 AT hook, DNA binding motif, containing 1
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1
ARL15 ADP-ribosylation factor-like 15
ARSB arylsulfatase B
ATP7B ATPase, Cu++ transporting, beta polypeptide
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BCAS1 breast carcinoma amplified sequence 1
BMP4 bone morphogenetic protein 4
C21ORF91 chromosome 21 open reading frame 91
CAPN15 calpain 15
CDKL3 cyclin-dependent kinase-like 3
CDR2L cerebellar degeneration-related protein 2-like
CHMP7 charged multivesicular body protein 7
CIT citron rho-interacting serine/threonine kinase
CLDN15 claudin 15
CLSPN claspin
CPPED1 calcineurin-like phosphoesterase domain containing 1
CPTP ceramide-1-phosphate transfer protein
CRBN cereblon
CTNNBIP1 catenin, beta interacting protein 1
CTSK cathepsin K
DCAF17 DDB1 and CUL4 associated factor 17
DENND4A DENN/MADD domain containing 4A
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
EDC4 enhancer of mRNA decapping 4
EGLN3 egl-9 family hypoxia-inducible factor 3
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
EVPL envoplakin
FAAH fatty acid amide hydrolase
FAM111A family with sequence similarity 111, member A
FAM114A1 family with sequence similarity 114, member A1
FAM189B family with sequence similarity 189, member B
GHR growth hormone receptor
GLTP glycolipid transfer protein
GPATCH1 G patch domain containing 1
GUSBP3 glucuronidase, beta pseudogene 3
HMHA1 histocompatibility (minor) HA-1
HOXC13 homeobox C13
HSPA2 heat shock 70kDa protein 2
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
ITPKC inositol-trisphosphate 3-kinase C
LMCD1 LIM and cysteine-rich domains 1
LRRC42 leucine rich repeat containing 42
LYPLA2P1 lysophospholipase II pseudogene 1
MAGEH1 melanoma antigen family H1
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MAST3 microtubule associated serine/threonine kinase 3
MED20 mediator complex subunit 20
MFSD12 major facilitator superfamily domain containing 12
MISP mitotic spindle positioning
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MON1B MON1 secretory trafficking family member B
MSX1 msh homeobox 1
MXD3 MAX dimerization protein 3
NAP1L2 nucleosome assembly protein 1-like 2
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PARG poly (ADP-ribose) glycohydrolase
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PILRB paired immunoglobin-like type 2 receptor beta
PLA2G10 phospholipase A2, group X
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLD2 phospholipase D2
POLE polymerase (DNA directed), epsilon, catalytic subunit
POLH polymerase (DNA directed), eta
PP14571 uncharacterized LOC100130449
PTBP2 polypyrimidine tract binding protein 2
PTPRU protein tyrosine phosphatase, receptor type, U
RASA2 RAS p21 protein activator 2
RECQL4 RecQ protein-like 4
RIBC2 RIB43A domain with coiled-coils 2
ROM1 retinal outer segment membrane protein 1
S100A4 S100 calcium binding protein A4
SCAI suppressor of cancer cell invasion
SDF2 stromal cell-derived factor 2
SETMAR SET domain and mariner transposase fusion gene
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SNHG3 small nucleolar RNA host gene 3
STAG3L1 stromal antigen 3-like 1 (pseudogene)
TACC3 transforming, acidic coiled-coil containing protein 3
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TESK2 testis-specific kinase 2
THBS3 thrombospondin 3
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TM7SF3 transmembrane 7 superfamily member 3
TMEM62 transmembrane protein 62
TMSB15A thymosin beta 15a
TPRA1 transmembrane protein, adipocyte asscociated 1
UNKL unkempt family zinc finger-like
USB1 U6 snRNA biogenesis 1
VEGFC vascular endothelial growth factor C
WDR4 WD repeat domain 4
XYLT2 xylosyltransferase II
ZBTB39 zinc finger and BTB domain containing 39
ZBTB6 zinc finger and BTB domain containing 6
ZNF205 zinc finger protein 205
ZNF668 zinc finger protein 668