ivermectin-5853 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the ivermectin-5853 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AKAP7 A kinase (PRKA) anchor protein 7
AKR1C2 aldo-keto reductase family 1, member C2
ALX4 ALX homeobox 4
APOC4 apolipoprotein C-IV
ARC activity-regulated cytoskeleton-associated protein
ARTN artemin
BAHCC1 BAH domain and coiled-coil containing 1
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit
BZRAP1 benzodiazepine receptor (peripheral) associated protein 1
CACTIN cactin, spliceosome C complex subunit
CCDC71 coiled-coil domain containing 71
CCL27 chemokine (C-C motif) ligand 27
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CDC14B cell division cycle 14B
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
CNGA1 cyclic nucleotide gated channel alpha 1
CNPPD1 cyclin Pas1/PHO80 domain containing 1
CTSF cathepsin F
CYLC1 cylicin, basic protein of sperm head cytoskeleton 1
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DDIT3 DNA-damage-inducible transcript 3
DDO D-aspartate oxidase
DLC1 DLC1 Rho GTPase activating protein
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DST dystonin
DTNA dystrobrevin, alpha
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EPHB2 EPH receptor B2
ERC1 ELKS/RAB6-interacting/CAST family member 1
FBXO40 F-box protein 40
GAN gigaxonin
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GSTA3 glutathione S-transferase alpha 3
HDAC5 histone deacetylase 5
ICOSLG inducible T-cell co-stimulator ligand
IGF1 insulin-like growth factor 1 (somatomedin C)
IGHM immunoglobulin heavy constant mu
IL11 interleukin 11
INADL InaD-like (Drosophila)
KYNU kynureninase
LPAR6 lysophosphatidic acid receptor 6
MAK male germ cell-associated kinase
MANBA mannosidase, beta A, lysosomal
METTL7A methyltransferase like 7A
MOBP myelin-associated oligodendrocyte basic protein
MXD4 MAX dimerization protein 4
MYRF myelin regulatory factor
NDRG1 N-myc downstream regulated 1
NF2 neurofibromin 2 (merlin)
NIPAL2 NIPA-like domain containing 2
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
NOTCH2 notch 2
NOTCH4 notch 4
NOX1 NADPH oxidase 1
NPY6R neuropeptide Y receptor Y6 (pseudogene)
OSMR oncostatin M receptor
PASK PAS domain containing serine/threonine kinase
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PDE10A phosphodiesterase 10A
PDLIM7 PDZ and LIM domain 7 (enigma)
PHF1 PHD finger protein 1
PLCD1 phospholipase C, delta 1
PPP4R4 protein phosphatase 4, regulatory subunit 4
PRAMEF11 PRAME family member 11
PROSER1 proline and serine rich 1
PTPRR protein tyrosine phosphatase, receptor type, R
RAB29 RAB29, member RAS oncogene family
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RASA2 RAS p21 protein activator 2
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RPL10 ribosomal protein L10
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RTEL1 regulator of telomere elongation helicase 1
RUNX1 runt-related transcription factor 1
SARM1 sterile alpha and TIR motif containing 1
SCAMP1 secretory carrier membrane protein 1
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOS2 son of sevenless homolog 2 (Drosophila)
SPTBN5 spectrin, beta, non-erythrocytic 5
STAC SH3 and cysteine rich domain
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
STARD3 StAR-related lipid transfer (START) domain containing 3
SYMPK symplekin
SYNJ2 synaptojanin 2
TAZ tafazzin
TENM1 teneurin transmembrane protein 1
TLE2 transducin-like enhancer of split 2
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
UTRN utrophin
WEE1 WEE1 G2 checkpoint kinase
WIZ widely interspaced zinc finger motifs
ZBTB20 zinc finger and BTB domain containing 20
ZNF227 zinc finger protein 227
ZNF334 zinc finger protein 334

decreased expression

Symbol Name
ACADSB acyl-CoA dehydrogenase, short/branched chain
ACIN1 apoptotic chromatin condensation inducer 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALG12 ALG12, alpha-1,6-mannosyltransferase
ALPK1 alpha-kinase 1
ARHGAP10 Rho GTPase activating protein 10
ATP7B ATPase, Cu++ transporting, beta polypeptide
AXIN1 axin 1
C19ORF40 chromosome 19 open reading frame 40
C5 complement component 5
CAPN15 calpain 15
CDADC1 cytidine and dCMP deaminase domain containing 1
CDCA3 cell division cycle associated 3
CDON cell adhesion associated, oncogene regulated
CENPT centromere protein T
CEP85 centrosomal protein 85kDa
CNTNAP3B contactin associated protein-like 3B
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTSK cathepsin K
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DEAF1 DEAF1 transcription factor
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
ERMAP erythroblast membrane-associated protein (Scianna blood group)
EVPL envoplakin
FANCE Fanconi anemia, complementation group E
FOXK2 forkhead box K2
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPATCH3 G patch domain containing 3
GRWD1 glutamate-rich WD repeat containing 1
HAMP hepcidin antimicrobial peptide
HIRA histone cell cycle regulator
HIST1H3G histone cluster 1, H3g
HLX H2.0-like homeobox
HPS6 Hermansky-Pudlak syndrome 6
IFNA14 interferon, alpha 14
INF2 inverted formin, FH2 and WH2 domain containing
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
IRAK4 interleukin-1 receptor-associated kinase 4
KCTD7 potassium channel tetramerization domain containing 7
KDELC1 KDEL (Lys-Asp-Glu-Leu) containing 1
KIAA1549L KIAA1549-like
KLHL3 kelch-like family member 3
LPAR3 lysophosphatidic acid receptor 3
LRRC6 leucine rich repeat containing 6
MCTP2 multiple C2 domains, transmembrane 2
NAG18 NAG18 mRNA
NARFL nuclear prelamin A recognition factor-like
NID2 nidogen 2 (osteonidogen)
NUBP2 nucleotide binding protein 2
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PALMD palmdelphin
PECR peroxisomal trans-2-enoyl-CoA reductase
PELI1 pellino E3 ubiquitin protein ligase 1
PHKG2 phosphorylase kinase, gamma 2 (testis)
PKN1 protein kinase N1
PLAC8 placenta-specific 8
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
POLM polymerase (DNA directed), mu
PRPH peripherin
PRSS22 protease, serine, 22
RAB17 RAB17, member RAS oncogene family
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RANBP17 RAN binding protein 17
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RNF121 ring finger protein 121
RPL10L ribosomal protein L10-like
SCRN3 secernin 3
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SHPK sedoheptulokinase
SHROOM2 shroom family member 2
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SMYD3 SET and MYND domain containing 3
SNORA21 small nucleolar RNA, H/ACA box 21
SPEG SPEG complex locus
SRBD1 S1 RNA binding domain 1
STAG3L4 stromal antigen 3-like 4 (pseudogene)
TFPT TCF3 (E2A) fusion partner (in childhood Leukemia)
TGFBR3 transforming growth factor, beta receptor III
TLN1 talin 1
TMEM184C transmembrane protein 184C
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TPCN1 two pore segment channel 1
TRDMT1 tRNA aspartic acid methyltransferase 1
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
USP18 ubiquitin specific peptidase 18
USP6NL USP6 N-terminal like
ZBED1 zinc finger, BED-type containing 1
ZFHX3 zinc finger homeobox 3
ZNF276 zinc finger protein 276
ZNF551 zinc finger protein 551
ZNF592 zinc finger protein 592
ZNF671 zinc finger protein 671
ZNF816 zinc finger protein 816