ivermectin-2213 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the ivermectin-2213 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
ADRA1B adrenoceptor alpha 1B
AREG amphiregulin
ASIC3 acid sensing (proton gated) ion channel 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BAIAP3 BAI1-associated protein 3
BET1L Bet1 golgi vesicular membrane trafficking protein-like
BIRC3 baculoviral IAP repeat containing 3
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit
CD70 CD70 molecule
CEMIP cell migration inducing protein, hyaluronan binding
CFB complement factor B
CGA glycoprotein hormones, alpha polypeptide
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLIC2 chloride intracellular channel 2
COL1A1 collagen, type I, alpha 1
CSHL1 chorionic somatomammotropin hormone-like 1
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DRD1 dopamine receptor D1
EFNB3 ephrin-B3
EPHB6 EPH receptor B6
FCAR Fc fragment of IgA receptor
GADD45A growth arrest and DNA-damage-inducible, alpha
GMPR guanosine monophosphate reductase
HBEGF heparin-binding EGF-like growth factor
HIST1H2BO histone cluster 1, H2bo
HIST1H4H histone cluster 1, H4h
HOXC5 homeobox C5
ICAM1 intercellular adhesion molecule 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IL1RN interleukin 1 receptor antagonist
IL2RG interleukin 2 receptor, gamma
INHBE inhibin, beta E
ISG20 interferon stimulated exonuclease gene 20kDa
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
LAMC2 laminin, gamma 2
LIF leukemia inhibitory factor
LINC00341 long intergenic non-protein coding RNA 341
LOC157562 uncharacterized LOC157562
LTB lymphotoxin beta (TNF superfamily, member 3)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MALL mal, T-cell differentiation protein-like
MAOA monoamine oxidase A
MBNL2 muscleblind-like splicing regulator 2
MEF2D myocyte enhancer factor 2D
MRC2 mannose receptor, C type 2
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
MYT1 myelin transcription factor 1
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
NF2 neurofibromin 2 (merlin)
NFIL3 nuclear factor, interleukin 3 regulated
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NNAT neuronatin
NR4A1 nuclear receptor subfamily 4, group A, member 1
NUPR1 nuclear protein, transcriptional regulator, 1
OASL 2'-5'-oligoadenylate synthetase-like
OPRK1 opioid receptor, kappa 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLK3 polo-like kinase 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP1R37 protein phosphatase 1, regulatory subunit 37
PSPH phosphoserine phosphatase
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RND1 Rho family GTPase 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
SERHL2 serine hydrolase-like 2
SH3BP2 SH3-domain binding protein 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC25A30 solute carrier family 25, member 30
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
THRB thyroid hormone receptor, beta
TLR2 toll-like receptor 2
TM4SF1 transmembrane 4 L six family member 1
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TPP1 tripeptidyl peptidase I
TREM1 triggering receptor expressed on myeloid cells 1
TRIB3 tribbles pseudokinase 3
TXNIP thioredoxin interacting protein
UPK1B uroplakin 1B
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ABHD3 abhydrolase domain containing 3
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAP2 ArfGAP with dual PH domains 2
ADCY7 adenylate cyclase 7
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
APOLD1 apolipoprotein L domain containing 1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARSB arylsulfatase B
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
ATP13A2 ATPase type 13A2
BCORL1 BCL6 corepressor-like 1
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
BTF3P12 basic transcription factor 3 pseudogene 12
C11ORF30 chromosome 11 open reading frame 30
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
C22ORF29 chromosome 22 open reading frame 29
C2ORF27A chromosome 2 open reading frame 27A
C2ORF68 chromosome 2 open reading frame 68
C5AR2 complement component 5a receptor 2
CA2 carbonic anhydrase II
CAMK1 calcium/calmodulin-dependent protein kinase I
CBX8 chromobox homolog 8
CDK18 cyclin-dependent kinase 18
CLCN6 chloride channel, voltage-sensitive 6
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CORO7 coronin 7
CPPED1 calcineurin-like phosphoesterase domain containing 1
CUZD1 CUB and zona pellucida-like domains 1
DMTN dematin actin binding protein
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
ERCC6L excision repair cross-complementation group 6-like
ERN2 endoplasmic reticulum to nucleus signaling 2
EXD3 exonuclease 3'-5' domain containing 3
FLT4 fms-related tyrosine kinase 4
FOXI1 forkhead box I1
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GATA4 GATA binding protein 4
HDAC11 histone deacetylase 11
HIST1H2BF histone cluster 1, H2bf
HSPA1L heat shock 70kDa protein 1-like
HSPA2 heat shock 70kDa protein 2
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
IFT140 intraflagellar transport 140
IL17RA interleukin 17 receptor A
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITPKB inositol-trisphosphate 3-kinase B
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KLHL25 kelch-like family member 25
L2HGDH L-2-hydroxyglutarate dehydrogenase
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LMO2 LIM domain only 2 (rhombotin-like 1)
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LRP2 low density lipoprotein receptor-related protein 2
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MBTPS2 membrane-bound transcription factor peptidase, site 2
METTL8 methyltransferase like 8
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
NEK11 NIMA-related kinase 11
NKAIN1 Na+/K+ transporting ATPase interacting 1
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
P3H1 prolyl 3-hydroxylase 1
PAIP2B poly(A) binding protein interacting protein 2B
PARD6A par-6 family cell polarity regulator alpha
PHACTR4 phosphatase and actin regulator 4
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PMP22 peripheral myelin protein 22
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRR4 proline rich 4 (lacrimal)
R3HCC1L R3H domain and coiled-coil containing 1-like
RAB30 RAB30, member RAS oncogene family
RBL1 retinoblastoma-like 1
RNF2 ring finger protein 2
RPL23AP32 ribosomal protein L23a pseudogene 32
SAYSD1 SAYSVFN motif domain containing 1
SCMH1 sex comb on midleg homolog 1 (Drosophila)
SCN1B sodium channel, voltage gated, type I beta subunit
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLIT2 slit homolog 2 (Drosophila)
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SYNC syncoilin, intermediate filament protein
TDRD1 tudor domain containing 1
TMEM164 transmembrane protein 164
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
UBQLN4 ubiquilin 4
UNC119 unc-119 homolog (C. elegans)
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae)
XK X-linked Kx blood group
ZIC3 Zic family member 3
ZNF611 zinc finger protein 611
ZNF675 zinc finger protein 675