ivermectin-2051 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the ivermectin-2051 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
ALOXE3 arachidonate lipoxygenase 3
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANKFY1 ankyrin repeat and FYVE domain containing 1
ANXA10 annexin A10
ARSB arylsulfatase B
ASPH aspartate beta-hydroxylase
BAX BCL2-associated X protein
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BEGAIN brain-enriched guanylate kinase-associated
BMP1 bone morphogenetic protein 1
C10ORF10 chromosome 10 open reading frame 10
C1R complement component 1, r subcomponent
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCL20 chemokine (C-C motif) ligand 20
CCNG2 cyclin G2
CD40 CD40 molecule, TNF receptor superfamily member 5
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2
CDK9 cyclin-dependent kinase 9
CDKL3 cyclin-dependent kinase-like 3
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHST4 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
CLCN7 chloride channel, voltage-sensitive 7
CNPPD1 cyclin Pas1/PHO80 domain containing 1
CREM cAMP responsive element modulator
CUL7 cullin 7
EGR1 early growth response 1
ETV5 ets variant 5
FAM214B family with sequence similarity 214, member B
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FZD8 frizzled class receptor 8
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GAST gastrin
GPR107 G protein-coupled receptor 107
GPR137 G protein-coupled receptor 137
GPR4 G protein-coupled receptor 4
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
HOMER3 homer scaffolding protein 3
HOOK1 hook microtubule-tethering protein 1
HOXC4 homeobox C4
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
KIF22 kinesin family member 22
KLF3 Kruppel-like factor 3 (basic)
KRT17 keratin 17, type I
KYNU kynureninase
LIME1 Lck interacting transmembrane adaptor 1
LINC00260 long intergenic non-protein coding RNA 260
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MAGEA6 melanoma antigen family A6
MAPK14 mitogen-activated protein kinase 14
MAPT microtubule-associated protein tau
MBTPS2 membrane-bound transcription factor peptidase, site 2
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta)
MCTP2 multiple C2 domains, transmembrane 2
MTUS1 microtubule associated tumor suppressor 1
MXD4 MAX dimerization protein 4
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NADK NAD kinase
NCOA2 nuclear receptor coactivator 2
NOTCH4 notch 4
NUPR1 nuclear protein, transcriptional regulator, 1
OXLD1 oxidoreductase-like domain containing 1
PARVB parvin, beta
PGPEP1 pyroglutamyl-peptidase I
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PML promyelocytic leukemia
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RGS4 regulator of G-protein signaling 4
RPS4Y1 ribosomal protein S4, Y-linked 1
SAFB2 scaffold attachment factor B2
SLC30A5 solute carrier family 30 (zinc transporter), member 5
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOCS6 suppressor of cytokine signaling 6
STON1 stonin 1
STS steroid sulfatase (microsomal), isozyme S
SYT17 synaptotagmin XVII
TBC1D30 TBC1 domain family, member 30
TENM4 teneurin transmembrane protein 4
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TM2D1 TM2 domain containing 1
TMEM259 transmembrane protein 259
TMEM53 transmembrane protein 53
TMEM57 transmembrane protein 57
TMF1 TATA element modulatory factor 1
TRIB3 tribbles pseudokinase 3
TRIM29 tripartite motif containing 29
TSC22D3 TSC22 domain family, member 3
WDFY3 WD repeat and FYVE domain containing 3
WIZ widely interspaced zinc finger motifs
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
ZBTB22 zinc finger and BTB domain containing 22
ZNF223 zinc finger protein 223

decreased expression

Symbol Name
AFAP1 actin filament associated protein 1
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
ANKRD27 ankyrin repeat domain 27 (VPS9 domain)
ATP10D ATPase, class V, type 10D
BDNF brain-derived neurotrophic factor
BEX4 brain expressed, X-linked 4
BRIP1 BRCA1 interacting protein C-terminal helicase 1
C16ORF59 chromosome 16 open reading frame 59
CCDC85C coiled-coil domain containing 85C
CCS copper chaperone for superoxide dismutase
CD70 CD70 molecule
CHEK2 checkpoint kinase 2
CRYBB2P1 crystallin, beta B2 pseudogene 1
DENND5B DENN/MADD domain containing 5B
DGKZ diacylglycerol kinase, zeta
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13
DNAL4 dynein, axonemal, light chain 4
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3
EDC4 enhancer of mRNA decapping 4
ENDOG endonuclease G
EPN3 epsin 3
EPPK1 epiplakin 1
ETV4 ets variant 4
FAM155A family with sequence similarity 155, member A
FAM193B family with sequence similarity 193, member B
FBXW12 F-box and WD repeat domain containing 12
FEM1C fem-1 homolog c (C. elegans)
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOXC1 forkhead box C1
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GLI3 GLI family zinc finger 3
GLTP glycolipid transfer protein
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa
GUSBP3 glucuronidase, beta pseudogene 3
HAUS6 HAUS augmin-like complex, subunit 6
HIRA histone cell cycle regulator
HIST1H2BJ histone cluster 1, H2bj
HYI hydroxypyruvate isomerase (putative)
HYMAI hydatidiform mole associated and imprinted (non-protein coding)
IL7R interleukin 7 receptor
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KRT8P12 keratin 8 pseudogene 12
LINC00339 long intergenic non-protein coding RNA 339
MAN2B2 mannosidase, alpha, class 2B, member 2
MFSD11 major facilitator superfamily domain containing 11
MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
MYBBP1A MYB binding protein (P160) 1a
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
NDRG4 NDRG family member 4
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NHLRC2 NHL repeat containing 2
NOL12 nucleolar protein 12
NRGN neurogranin (protein kinase C substrate, RC3)
NRSN2 neurensin 2
NUBP2 nucleotide binding protein 2
ORAI3 ORAI calcium release-activated calcium modulator 3
PAQR3 progestin and adipoQ receptor family member III
PARPBP PARP1 binding protein
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa
PECR peroxisomal trans-2-enoyl-CoA reductase
PIBF1 progesterone immunomodulatory binding factor 1
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLA2G15 phospholipase A2, group XV
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEKHA6 pleckstrin homology domain containing, family A member 6
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
POLR1B polymerase (RNA) I polypeptide B, 128kDa
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
PPAN peter pan homolog (Drosophila)
PYCRL pyrroline-5-carboxylate reductase-like
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae)
RFWD3 ring finger and WD repeat domain 3
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae)
RPUSD2 RNA pseudouridylate synthase domain containing 2
RUSC2 RUN and SH3 domain containing 2
SCML2 sex comb on midleg-like 2 (Drosophila)
SDC3 syndecan 3
SIX1 SIX homeobox 1
SLC39A1 solute carrier family 39 (zinc transporter), member 1
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
TBL3 transducin (beta)-like 3
TCTN1 tectonic family member 1
TGS1 trimethylguanosine synthase 1
TM7SF3 transmembrane 7 superfamily member 3
TMEM165 transmembrane protein 165
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TUBA3C tubulin, alpha 3c
TUBB2B tubulin, beta 2B class IIb
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2
UNKL unkempt family zinc finger-like
WDR3 WD repeat domain 3
WNT10B wingless-type MMTV integration site family, member 10B
ZMAT5 zinc finger, matrin-type 5
ZNF276 zinc finger protein 276
ZNF324 zinc finger protein 324
ZNF580 zinc finger protein 580
ZNF813 zinc finger protein 813