irritable bowel syndrome Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A syndrome that is a functional bowel disorder characterized by chronic abdominal pain, discomfort, bloating, and alteration of bowel habits in the absence of any detectable organic cause. (Human Disease Ontology, DOID_9778)
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Genes

219 genes co-occuring with the disease irritable bowel syndrome in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 2.5867
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 2.02341
CRH corticotropin releasing hormone 1.91453
CCK cholecystokinin 1.73413
LCT lactase 1.72319
GUCY2C guanylate cyclase 2C 1.69496
NPR1 natriuretic peptide receptor 1 1.62336
CRHR1 corticotropin releasing hormone receptor 1 1.6162
TRPV1 transient receptor potential cation channel, subfamily V, member 1 1.57512
TAC1 tachykinin, precursor 1 1.57022
TPH1 tryptophan hydroxylase 1 1.5304
MLN motilin 1.4588
KLB klotho beta 1.38909
HTR3E 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic 1.35943
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 1.27214
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 1.2717
LTF lactotransferrin 1.25645
ITM2B integral membrane protein 2B 1.23733
OCLN occludin 1.23082
HTR3D 5-hydroxytryptamine (serotonin) receptor 3D, ionotropic 1.22302
F2RL1 coagulation factor II (thrombin) receptor-like 1 1.20483
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 1.17292
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic 1.16264
TACR2 tachykinin receptor 2 1.12361
PYY peptide YY 1.10678
TACR1 tachykinin receptor 1 1.09167
FGF19 fibroblast growth factor 19 1.06984
PARM1 prostate androgen-regulated mucin-like protein 1 1.06732
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 1.04335
TJP1 tight junction protein 1 1.03409
CCKAR cholecystokinin A receptor 1.03325
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3 1.00963
SST somatostatin 0.988114
CHGA chromogranin A 0.96918
CD79A CD79a molecule, immunoglobulin-associated alpha 0.967083
FGFR4 fibroblast growth factor receptor 4 0.960797
NPS neuropeptide S 0.946186
FOS FBJ murine osteosarcoma viral oncogene homolog 0.944938
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.944106
ASIC3 acid sensing (proton gated) ion channel 3 0.938289
CRHR2 corticotropin releasing hormone receptor 2 0.908553
VIP vasoactive intestinal peptide 0.899103
UBASH3B ubiquitin associated and SH3 domain containing B 0.887618
UCN urocortin 0.866321
UCN3 urocortin 3 0.857315
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 0.850354
P2RY4 pyrimidinergic receptor P2Y, G-protein coupled, 4 0.838066
S100A12 S100 calcium binding protein A12 0.831918
TMEM133 transmembrane protein 133 0.816334
CNR1 cannabinoid receptor 1 (brain) 0.815514
ADRA2A adrenoceptor alpha 2A 0.764718
AQP8 aquaporin 8 0.758601
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 0.753306
KCNQ4 potassium channel, voltage gated KQT-like subfamily Q, member 4 0.731786
MLNR motilin receptor 0.731381
CLCN2 chloride channel, voltage-sensitive 2 0.728547
MPO myeloperoxidase 0.716828
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.708767
CLDN1 claudin 1 0.705949
HTR3C 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic 0.70434
CRP C-reactive protein, pentraxin-related 0.701526
POMC proopiomelanocortin 0.694301
TRPA1 transient receptor potential cation channel, subfamily A, member 1 0.683892
BHLHE22 basic helix-loop-helix family, member e22 0.662784
IL1B interleukin 1, beta 0.65565
GHRL ghrelin/obestatin prepropeptide 0.641827
GPR161 G protein-coupled receptor 161 0.63907
IL10 interleukin 10 0.634349
UCN2 urocortin 2 0.633956
FAF2 Fas associated factor family member 2 0.62728
NXPH1 neurexophilin 1 0.626888
OPRL1 opiate receptor-like 1 0.615138
HRH4 histamine receptor H4 0.608885
OR2H2 olfactory receptor, family 2, subfamily H, member 2 0.608494
TRPV4 transient receptor potential cation channel, subfamily V, member 4 0.608494
FAAH fatty acid amide hydrolase 0.605372
AQP10 aquaporin 10 0.60264
GAST gastrin 0.596012
GPBAR1 G protein-coupled bile acid receptor 1 0.588222
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 0.587833
OR2B2 olfactory receptor, family 2, subfamily B, member 2 0.585497
NPY neuropeptide Y 0.570329
NGF nerve growth factor (beta polypeptide) 0.55945
ADRB3 adrenoceptor beta 3 0.55945
CCKBR cholecystokinin B receptor 0.559062
OPRM1 opioid receptor, mu 1 0.548971
SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter), member 2 0.546644
PDZD3 PDZ domain containing 3 0.543542
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.541605
ATP5J ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6 0.539667
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.533861
TMEM131 transmembrane protein 131 0.531541
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 0.531154
PPY pancreatic polypeptide 0.525746
C4BPA complement component 4 binding protein, alpha 0.524974
CALCA calcitonin-related polypeptide alpha 0.52343
CLDN7 claudin 7 0.511496
TLR4 toll-like receptor 4 0.507657
CELA1 chymotrypsin-like elastase family, member 1 0.506507
CNOT2 CCR4-NOT transcription complex, subunit 2 0.501909
CELA3B chymotrypsin-like elastase family, member 3B 0.496557
TNF tumor necrosis factor 0.491978
CAPN8 calpain 8 0.488169
GUCA2B guanylate cyclase activator 2B (uroguanylin) 0.483224
CCR9 chemokine (C-C motif) receptor 9 0.479807
NAV2 neuron navigator 2 0.478668
TACR3 tachykinin receptor 3 0.47753
AVPR2 arginine vasopressin receptor 2 0.468819
TLR8 toll-like receptor 8 0.467684
SLCO6A1 solute carrier organic anion transporter family, member 6A1 0.463527
CCL16 chemokine (C-C motif) ligand 16 0.460506
PROKR1 prokineticin receptor 1 0.459373
PNOC prepronociceptin 0.456732
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain 0.448817
TNFRSF17 tumor necrosis factor receptor superfamily, member 17 0.447311
TJP2 tight junction protein 2 0.433397
CGN cingulin 0.433397
ITGB7 integrin, beta 7 0.43227
MPDZ multiple PDZ domain protein 0.430768
MED28 mediator complex subunit 28 0.430393
PDYN prodynorphin 0.430017
STYK1 serine/threonine/tyrosine kinase 1 0.428891
ALB albumin 0.42289
SP6 Sp6 transcription factor 0.418394
PDIA3 protein disulfide isomerase family A, member 3 0.417644
NR1H4 nuclear receptor subfamily 1, group H, member 4 0.411283
PNN pinin, desmosome associated protein 0.405305
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.397471
S100A10 S100 calcium binding protein A10 0.388538
MARK4 MAP/microtubule affinity-regulating kinase 4 0.385936
ASIC1 acid sensing (proton gated) ion channel 1 0.382594
HNRNPF heterogeneous nuclear ribonucleoprotein F 0.379626
SCG3 secretogranin III 0.378885
NLRP6 NLR family, pyrin domain containing 6 0.376661
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.37592
LRP5 low density lipoprotein receptor-related protein 5 0.375179
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.373698
SV2A synaptic vesicle glycoprotein 2A 0.364085
PROK2 prokineticin 2 0.361502
IL6 interleukin 6 0.359289
TLR5 toll-like receptor 5 0.357814
CTSC cathepsin C 0.347879
NUCB2 nucleobindin 2 0.346777
PRLH prolactin releasing hormone 0.343106
CD4 CD4 molecule 0.340906
CXCL8 chemokine (C-X-C motif) ligand 8 0.335412
GCG glucagon 0.331756
DEFB4A defensin, beta 4A 0.326281
BDNF brain-derived neurotrophic factor 0.321909
NTS neurotensin 0.321909
GNAT1 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 0.317182
TRPM8 transient receptor potential cation channel, subfamily M, member 8 0.316092
MADCAM1 mucosal vascular addressin cell adhesion molecule 1 0.315729
COMT catechol-O-methyltransferase 0.313189
RBBP9 retinoblastoma binding protein 9 0.305587
PRDX6 peroxiredoxin 6 0.300533
TRPM5 transient receptor potential cation channel, subfamily M, member 5 0.300173
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16 0.292975
NR1D1 nuclear receptor subfamily 1, group D, member 1 0.289386
PXDN peroxidasin 0.289386
APOLD1 apolipoprotein L domain containing 1 0.286877
PRRC2A proline-rich coiled-coil 2A 0.285802
MYLK3 myosin light chain kinase 3 0.285444
HRH2 histamine receptor H2 0.285086
RPSA ribosomal protein SA 0.283655
TLR6 toll-like receptor 6 0.28294
ATAD3C ATPase family, AAA domain containing 3C 0.280796
ANO7P1 anoctamin 7 pseudogene 1 0.279724
SHKBP1 SH3KBP1 binding protein 1 0.278297
MEFV Mediterranean fever 0.273308
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1 0.272597
MGP matrix Gla protein 0.270108
CTSS cathepsin S 0.265849
FABP6 fatty acid binding protein 6, ileal 0.264785
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon 0.260538
FAM131C family with sequence similarity 131, member C 0.260184
MYLK myosin light chain kinase 0.259124
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 0.254888
CBS cystathionine-beta-synthase 0.254183
CYP2D7 cytochrome P450, family 2, subfamily D, polypeptide 7 (gene/pseudogene) 0.251015
CBR1 carbonyl reductase 1 0.241895
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 0.241895
CARS cysteinyl-tRNA synthetase 0.241895
SP9 Sp9 transcription factor 0.235964
TARBP2 TAR (HIV-1) RNA binding protein 2 0.23353
IGHE immunoglobulin heavy constant epsilon 0.231448
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 0.231102
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 0.223165
TRPV3 transient receptor potential cation channel, subfamily V, member 3 0.221793
GLO1 glyoxalase I 0.220766
IDO1 indoleamine 2,3-dioxygenase 1 0.213621
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12 0.213283
TLR9 toll-like receptor 9 0.212608
TLR2 toll-like receptor 2 0.211597
CSN1S1 casein alpha s1 0.209918
UBD ubiquitin D 0.208245
SPAG7 sperm associated antigen 7 0.205916
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.202946
FICD FIC domain containing 0.201635
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits 0.198386
ADCY1 adenylate cyclase 1 (brain) 0.198064
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4 0.197742
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1 0.19742
LY96 lymphocyte antigen 96 0.192657
GIP gastric inhibitory polypeptide 0.190168
CLDN4 claudin 4 0.189859
LCN2 lipocalin 2 0.189551
TRPC4 transient receptor potential cation channel, subfamily C, member 4 0.189244
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 0.185612
TLR7 toll-like receptor 7 0.185313
GAN gigaxonin 0.177029
MIR21 microRNA 21 0.173057
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 0.169571
TLR1 toll-like receptor 1 0.16933
MGLL monoglyceride lipase 0.164571
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 0.161523
PRKCZ protein kinase C, zeta 0.160948
TAGLN transgelin 0.160948
TRPM6 transient receptor potential cation channel, subfamily M, member 6 0.159124