iron metabolism disease Gene Set

Dataset GWASdb SNP-Disease Associations
Category disease or phenotype associations
Type disease
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/DOID:2351
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Genes

233 genes associated with the disease iron metabolism disease in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.

Symbol Name Standardized Value
TF transferrin 2.52649
PCSK7 proprotein convertase subtilisin/kexin type 7 2.21414
SIK3 SIK family kinase 3 2.19289
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) 2.16063
SIDT2 SID1 transmembrane family, member 2 2.12381
SELENBP1 selenium binding protein 1 2.01212
PPCDC phosphopantothenoylcysteine decarboxylase 1.94711
RAB6B RAB6B, member RAS oncogene family 1.90828
TAGLN transgelin 1.8834
TMPRSS6 transmembrane protease, serine 6 1.82268
HFE hemochromatosis 1.81431
SRPRB signal recognition particle receptor, B subunit 1.80315
APOA5 apolipoprotein A-V 1.76651
ZPR1 ZPR1 zinc finger 1.72879
BUD13 BUD13 homolog (S. cerevisiae) 1.72677
APOA4 apolipoprotein A-IV 1.70827
CA1 carbonic anhydrase I 1.65151
CP ceruloplasmin (ferroxidase) 1.62029
SLC17A1 solute carrier family 17 (organic anion transporter), member 1 1.51254
CDV3 CDV3 homolog (mouse) 1.43957
TFR2 transferrin receptor 2 1.33186
FNTB farnesyltransferase, CAAX box, beta 1.31635
LRRC16A leucine rich repeat containing 16A 1.26953
EPHA6 EPH receptor A6 1.26953
LINC00536 long intergenic non-protein coding RNA 536 1.26335
TYR tyrosinase 1.24313
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 1.19609
ANK2 ankyrin 2, neuronal 1.19386
ADRA1A adrenoceptor alpha 1A 1.18117
MDN1 MDN1, midasin homolog (yeast) 1.17101
TRAK1 trafficking protein, kinesin binding 1 1.1662
TTC7B tetratricopeptide repeat domain 7B 1.16574
LUZP2 leucine zipper protein 2 1.14463
KLHL13 kelch-like family member 13 1.14463
TCERG1L transcription elongation regulator 1-like 1.14463
TMEM132C transmembrane protein 132C 1.14065
KLF12 Kruppel-like factor 12 1.14065
AGBL1 ATP/GTP binding protein-like 1 1.13689
KIRREL kin of IRRE like (Drosophila) 1.13288
SERPINA9 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9 1.12892
PLXDC2 plexin domain containing 2 1.12155
PARD3B par-3 family cell polarity regulator beta 1.11123
PLEKHH2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 1.10419
PRPSAP2 phosphoribosyl pyrophosphate synthetase-associated protein 2 1.09462
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 1.08148
LRRC17 leucine rich repeat containing 17 1.04846
RUNX1 runt-related transcription factor 1 1.03858
RFC3 replication factor C (activator 1) 3, 38kDa 1.03626
TENM4 teneurin transmembrane protein 4 1.03399
LMBRD1 LMBR1 domain containing 1 1.02027
GPHN gephyrin 0.996743
DLG2 discs, large homolog 2 (Drosophila) 0.989716
GHR growth hormone receptor 0.986376
ARSB arylsulfatase B 0.986376
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.967072
KIAA1217 KIAA1217 0.95885
UNC5C unc-5 homolog C (C. elegans) 0.93456
SHC4 SHC (Src homology 2 domain containing) family, member 4 0.932777
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.928472
AKAP6 A kinase (PRKA) anchor protein 6 0.928472
ST6GALNAC6 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 0.927636
ACBD3 acyl-CoA binding domain containing 3 0.925987
STOM stomatin 0.921998
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 0.920453
ATXN1 ataxin 1 0.912987
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.905653
LRRC3B leucine rich repeat containing 3B 0.898875
DOCK1 dedicator of cytokinesis 1 0.898875
PHIP pleckstrin homology domain interacting protein 0.898875
COL27A1 collagen, type XXVII, alpha 1 0.898875
NCKAP5 NCK-associated protein 5 0.892579
GRM7 glutamate receptor, metabotropic 7 0.890776
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.886521
SLC44A3 solute carrier family 44, member 3 0.88338
CACHD1 cache domain containing 1 0.874542
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 0.869084
ZBTB20 zinc finger and BTB domain containing 20 0.859982
SATB2 SATB homeobox 2 0.853791
MYEOV2 myeloma overexpressed 2 0.848917
ZNF202 zinc finger protein 202 0.848917
RIMS2 regulating synaptic membrane exocytosis 2 0.848917
TMEM225 transmembrane protein 225 0.831584
MADCAM1 mucosal vascular addressin cell adhesion molecule 1 0.801304
KYNU kynureninase 0.790866
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 0.787593
CSMD1 CUB and Sushi multiple domains 1 0.781342
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.775452
RYR2 ryanodine receptor 2 (cardiac) 0.769887
LINC00371 long intergenic non-protein coding RNA 371 0.766993
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 0.764659
OR6T1 olfactory receptor, family 6, subfamily T, member 1 0.758489
PTPRM protein tyrosine phosphatase, receptor type, M 0.756064
DPYSL2 dihydropyrimidinase-like 2 0.755798
C10ORF11 chromosome 10 open reading frame 11 0.753693
LINC00189 long intergenic non-protein coding RNA 189 0.749605
CAPN13 calpain 13 0.748856
CHST9 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9 0.743283
PTPRG protein tyrosine phosphatase, receptor type, G 0.74211
TGFBI transforming growth factor, beta-induced, 68kDa 0.740261
CASC15 cancer susceptibility candidate 15 (non-protein coding) 0.739121
GLI3 GLI family zinc finger 3 0.716372
TMCC3 transmembrane and coiled-coil domain family 3 0.710228
LPL lipoprotein lipase 0.69756
MED27 mediator complex subunit 27 0.689554
CTIF CBP80/20-dependent translation initiation factor 0.686305
PDE10A phosphodiesterase 10A 0.684345
CD109 CD109 molecule 0.6784
NELL1 NEL-like 1 (chicken) 0.67631
GBP6 guanylate binding protein family, member 6 0.672258
ZNF592 zinc finger protein 592 0.663947
UHRF1 ubiquitin-like with PHD and ring finger domains 1 0.653298
FAM19A2 family with sequence similarity 19 (chemokine (C-C motif)-like), member A2 0.644765
CHCHD6 coiled-coil-helix-coiled-coil-helix domain containing 6 0.635554
CTTNBP2 cortactin binding protein 2 0.63232
LOC100505776 0.630132
IST1 increased sodium tolerance 1 homolog (yeast) 0.628889
LIPC lipase, hepatic 0.622682
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.62159
FAM13A family with sequence similarity 13, member A 0.612357
GRM1 glutamate receptor, metabotropic 1 0.611353
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 0.610694
TSHZ3 teashirt zinc finger homeobox 3 0.60781
NCS1 neuronal calcium sensor 1 0.606266
F13A1 coagulation factor XIII, A1 polypeptide 0.60417
MOB3B MOB kinase activator 3B 0.603584
MYO10 myosin X 0.602717
SIRPB2 signal-regulatory protein beta 2 0.601861
CDK5RAP1 CDK5 regulatory subunit associated protein 1 0.600463
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.599368
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.59854
LRTM2 leucine-rich repeats and transmembrane domains 2 0.597094
CHSY3 chondroitin sulfate synthase 3 0.592944
ATXN7L1 ataxin 7-like 1 0.592146
ALMS1 Alstrom syndrome protein 1 0.591358
WRN Werner syndrome, RecQ helicase-like 0.589052
PLXNC1 plexin C1 0.586104
SLC8A3 solute carrier family 8 (sodium/calcium exchanger), member 3 0.586104
ESD esterase D 0.585865
LOC100506474 uncharacterized LOC100506474 0.584916
SHISA6 shisa family member 6 0.580999
CCDC162P coiled-coil domain containing 162, pseudogene 0.580521
TREM1 triggering receptor expressed on myeloid cells 1 0.580283
KCTD17 potassium channel tetramerization domain containing 17 0.579575
LPAR5 lysophosphatidic acid receptor 5 0.579107
FABP3 fatty acid binding protein 3, muscle and heart 0.577951
THSD7A thrombospondin, type I, domain containing 7A 0.577951
EDAR ectodysplasin A receptor 0.577041
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.574169
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.573738
MMRN1 multimerin 1 0.57331
NFASC neurofascin 0.572673
ALPK3 alpha-kinase 3 0.5708
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase 0.568383
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6 0.563808
ELMOD2 ELMO/CED-12 domain containing 2 0.563624
DLGAP3 discs, large (Drosophila) homolog-associated protein 3 0.562455
NUMB numb homolog (Drosophila) 0.561491
SH3GL2 SH3-domain GRB2-like 2 0.561109
PTPRD protein tyrosine phosphatase, receptor type, D 0.560351
MRPL3 mitochondrial ribosomal protein L3 0.560351
SOGA1 suppressor of glucose, autophagy associated 1 0.559788
PARK2 parkin RBR E3 ubiquitin protein ligase 0.559788
SIM2 single-minded family bHLH transcription factor 2 0.559601
ADGB androglobin 0.557402
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 0.556507
GCM1 glial cells missing homolog 1 (Drosophila) 0.555799
TSPEAR thrombospondin-type laminin G domain and EAR repeats 0.554062
ALOX5AP arachidonate 5-lipoxygenase-activating protein 0.55338
NALCN sodium leak channel, non selective 0.552369
CNTNAP5 contactin associated protein-like 5 0.550555
CHSY1 chondroitin sulfate synthase 1 0.54879
MEGF11 multiple EGF-like-domains 11 0.54879
KLHL14 kelch-like family member 14 0.548632
CFAP54 cilia and flagella associated 54 0.548632
OLFM1 olfactomedin 1 0.54738
EIF6 eukaryotic translation initiation factor 6 0.543994
SUGP1 SURP and G patch domain containing 1 0.541821
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.541668
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 0.54016
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) 0.539566
KDM4B lysine (K)-specific demethylase 4B 0.535966
PALLD palladin, cytoskeletal associated protein 0.535966
LYSMD2 LysM, putative peptidoglycan-binding, domain containing 2 0.535826
C1ORF100 chromosome 1 open reading frame 100 0.531752
DLC1 DLC1 Rho GTPase activating protein 0.530705
TTL tubulin tyrosine ligase 0.530188
IGF1R insulin-like growth factor 1 receptor 0.529039
CLIC5 chloride intracellular channel 5 0.528409
INADL InaD-like (Drosophila) 0.528159
FMN1 formin 1 0.528159
GRIK2 glutamate receptor, ionotropic, kainate 2 0.526189
FAM71B family with sequence similarity 71, member B 0.526189
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.525946
TTC17 tetratricopeptide repeat domain 17 0.525826
ZIC5 Zic family member 5 0.525705
SGCZ sarcoglycan, zeta 0.525103
ETV1 ets variant 1 0.525103
LRRC8A leucine rich repeat containing 8 family, member A 0.524507
TCF12 transcription factor 12 0.52115
PRPF18 pre-mRNA processing factor 18 0.518278
LOC401324 uncharacterized LOC401324 0.518063
PTTG1 pituitary tumor-transforming 1 0.517847
NCOR2 nuclear receptor corepressor 2 0.517313
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 0.516047
NBAS neuroblastoma amplified sequence 0.51563
KLK14 kallikrein-related peptidase 14 0.51399
C9 complement component 9 0.512985
CPN1 carboxypeptidase N, polypeptide 1 0.512489
SUSD1 sushi domain containing 1 0.512489
PZP pregnancy-zone protein 0.51239
METTL13 methyltransferase like 13 0.51239
TGM5 transglutaminase 5 0.511996
RNF157 ring finger protein 157 0.511507
NBEA neurobeachin 0.51054
CORO2A coronin, actin binding protein, 2A 0.510252
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 0.509492
PARVA parvin, alpha 0.507539
SOX13 SRY (sex determining region Y)-box 13 0.506889
CPNE4 copine IV 0.506035
TMOD2 tropomodulin 2 (neuronal) 0.504572
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.50423
VIMP VCP-interacting membrane selenoprotein 0.503822
CCDC172 coiled-coil domain containing 172 0.503822
BCAS1 breast carcinoma amplified sequence 1 0.502883
CADPS Ca++-dependent secretion activator 0.502156
KIAA0319 KIAA0319 0.501699
DDX27 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 0.500225
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.498668
LTBP1 latent transforming growth factor beta binding protein 1 0.498668
PRLR prolactin receptor 0.498362
TSHZ2 teashirt zinc finger homeobox 2 0.497817
DTNB dystrobrevin, beta 0.497336
ZNF12 zinc finger protein 12 0.496506