interstrand cross-link repair Gene Set

Dataset GO Biological Process Annotations
Category structural or functional annotations
Type biological process
Description Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication. (Gene Ontology, GO_0036297)
External Link
Similar Terms
Downloads & Tools


7 genes participating in the interstrand cross-link repair biological process from the curated GO Biological Process Annotations dataset.

Symbol Name
C1ORF86 chromosome 1 open reading frame 86
ERCC1 excision repair cross-complementation group 1
EXO5 exonuclease 5
FAN1 FANCD2/FANCI-associated nuclease 1
POLN polymerase (DNA directed) nu
RNF168 ring finger protein 168, E3 ubiquitin protein ligase
RNF8 ring finger protein 8, E3 ubiquitin protein ligase