intercalated disc Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells. (Gene Ontology, GO_0014704)
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Genes

126 proteins co-occuring with the intercalated disc cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
GJA1 gap junction protein, alpha 1, 43kDa 2.66208
PKP2 plakophilin 2 2.11294
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 1.87106
DSP desmoplakin 1.71063
JUP junction plakoglobin 1.55821
DSG2 desmoglein 2 1.5034
VCL vinculin 1.49888
XIRP1 xin actin binding repeat containing 1 1.3543
GJA5 gap junction protein, alpha 5, 40kDa 1.31789
GJC1 gap junction protein, gamma 1, 45kDa 1.25759
XIRP2 xin actin binding repeat containing 2 1.17311
DSC2 desmocollin 2 1.16491
DMPK dystrophia myotonica-protein kinase 1.07207
CTNNA3 catenin (cadherin-associated protein), alpha 3 1.03679
TJP1 tight junction protein 1 0.943059
TMEM43 transmembrane protein 43 0.897183
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 0.869966
SCN5A sodium channel, voltage gated, type V alpha subunit 0.866746
CLEC4F C-type lectin domain family 4, member F 0.863528
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.862149
NRAP nebulin-related anchoring protein 0.847451
CDC42BPG CDC42 binding protein kinase gamma (DMPK-like) 0.830007
CLMP CXADR-like membrane protein 0.820829
CSRNP3 cysteine-serine-rich nuclear protein 3 0.807982
DMD dystrophin 0.790106
SCN8A sodium channel, voltage gated, type VIII alpha subunit 0.75317
RANGRF RAN guanine nucleotide release factor 0.731076
CXADR coxsackie virus and adenovirus receptor 0.725258
MYOZ1 myozenin 1 0.722134
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.696905
POPDC3 popeye domain containing 3 0.694709
FLNC filamin C, gamma 0.693393
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.683771
TTN titin 0.677673
SCN3A sodium channel, voltage gated, type III alpha subunit 0.674196
SCN1B sodium channel, voltage gated, type I beta subunit 0.662503
ACTC1 actin, alpha, cardiac muscle 1 0.644858
POPDC2 popeye domain containing 2 0.640145
FERMT2 fermitin family member 2 0.639289
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 0.636723
VASP vasodilator-stimulated phosphoprotein 0.635868
ALPK3 alpha-kinase 3 0.617557
DSC3 desmocollin 3 0.605284
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 0.603596
BVES blood vessel epicardial substance 0.599802
NPPA natriuretic peptide A 0.580086
DLG1 discs, large homolog 1 (Drosophila) 0.573411
PDLIM3 PDZ and LIM domain 3 0.570913
NEB nebulin 0.560943
MYPN myopalladin 0.550599
PERP PERP, TP53 apoptosis effector 0.547297
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) 0.54606
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 0.520615
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 0.51694
TNNT2 troponin T type 2 (cardiac) 0.51164
ANXA6 annexin A6 0.511233
SRF serum response factor (c-fos serum response element-binding transcription factor) 0.502693
COL13A1 collagen, type XIII, alpha 1 0.4958
SCN4A sodium channel, voltage gated, type IV alpha subunit 0.475223
PGM5 phosphoglucomutase 5 0.468001
CTNND1 catenin (cadherin-associated protein), delta 1 0.4676
STRN striatin, calmodulin binding protein 0.4676
DES desmin 0.462798
KCNIP2 Kv channel interacting protein 2 0.453621
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 0.445275
GATA4 GATA binding protein 4 0.44052
GPD1L glycerol-3-phosphate dehydrogenase 1-like 0.434196
VAMP5 vesicle-associated membrane protein 5 0.414555
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B) 0.407529
CRYAB crystallin, alpha B 0.404804
YOD1 YOD1 deubiquitinase 0.395873
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.394323
CMYA5 cardiomyopathy associated 5 0.393936
AHNAK AHNAK nucleoprotein 0.393549
MAP2K7 mitogen-activated protein kinase kinase 7 0.392388
CDY2A chromodomain protein, Y-linked, 2A 0.387365
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 0.384665
ANKRD23 ankyrin repeat domain 23 0.376202
LIMS2 LIM and senescent cell antigen-like domains 2 0.347208
CSRP2 cysteine and glycine-rich protein 2 0.338884
LIMS3 LIM and senescent cell antigen-like domains 3 0.338884
OBSL1 obscurin-like 1 0.336241
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7 0.333602
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF 0.322325
LEFTY1 left-right determination factor 1 0.319702
EMD emerin 0.316708
HSPB2 heat shock 27kDa protein 2 0.303655
TNNI3 troponin I type 3 (cardiac) 0.298084
TLN2 talin 2 0.296972
DST dystonin 0.292527
ANK1 ankyrin 1, erythrocytic 0.291417
GJB1 gap junction protein, beta 1, 32kDa 0.286245
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta 0.285507
ANXA5 annexin A5 0.280716
DNM2 dynamin 2 0.278509
PTPRM protein tyrosine phosphatase, receptor type, M 0.274101
UTRN utrophin 0.263485
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 0.262755
BHLHE22 basic helix-loop-helix family, member e22 0.260202
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.258016
GLB1 galactosidase, beta 1 0.256925
MYOT myotilin 0.248578
LEFTY2 left-right determination factor 2 0.239557
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.238837
KCNC4 potassium channel, voltage gated Shaw related subfamily C, member 4 0.231315
CAV3 caveolin 3 0.218563
HAND2 heart and neural crest derivatives expressed 2 0.21716
MYOCD myocardin 0.214366
GFAP glial fibrillary acidic protein 0.209858
PKP4 plakophilin 4 0.208481
AQP6 aquaporin 6, kidney specific 0.207108
DNAH8 dynein, axonemal, heavy chain 8 0.20574
MYOM2 myomesin 2 0.204039
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome 0.196999
FGF2 fibroblast growth factor 2 (basic) 0.193719
LMNA lamin A/C 0.19307
NEK6 NIMA-related kinase 6 0.181524
APLNR apelin receptor 0.180634
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 0.179167
FHOD1 formin homology 2 domain containing 1 0.167125
LDB3 LIM domain binding 3 0.165932
TJP2 tight junction protein 2 0.165697
NOS3 nitric oxide synthase 3 (endothelial cell) 0.164542
NRG1 neuregulin 1 0.163865
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 0.161693
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 0.160053