inhibitory synapse Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A synapse in which an action potential in the presynaptic cell reduces the probability of an action potential occurring in the postsynaptic cell. (Gene Ontology, GO_0060077)
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Genes

154 proteins co-occuring with the inhibitory synapse cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
GPHN gephyrin 3.01563
NLGN2 neuroligin 2 2.34884
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9 1.77339
NLGN1 neuroligin 1 1.66901
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1 1.5656
BDNF brain-derived neurotrophic factor 1.4041
CARF calcium responsive transcription factor 1.35923
NPAS4 neuronal PAS domain protein 4 1.35266
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 1.29264
SLITRK3 SLIT and NTRK-like family, member 3 1.28836
PVALB parvalbumin 1.25443
NRXN1 neurexin 1 1.1726
CNR1 cannabinoid receptor 1 (brain) 1.15774
NXPH1 neurexophilin 1 1.13369
NLGN3 neuroligin 3 1.12756
GABARAP GABA(A) receptor-associated protein 1.10154
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 1.0934
LRRTM2 leucine rich repeat transmembrane neuronal 2 1.08272
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase 1.06195
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 1.02231
SYT15 synaptotagmin XV 1.00399
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 0.989759
IGSF9B immunoglobulin superfamily, member 9B 0.987317
IQSEC3 IQ motif and Sec7 domain 3 0.980016
TMEM144 transmembrane protein 144 0.976135
CLSTN3 calsyntenin 3 0.962627
MDGA1 MAM domain containing glycosylphosphatidylinositol anchor 1 0.952573
DAGLA diacylglycerol lipase, alpha 0.920918
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 0.914842
DAGLB diacylglycerol lipase, beta 0.848369
FCN3 ficolin (collagen/fibrinogen domain containing) 3 0.831384
DSE dermatan sulfate epimerase 0.806148
GRIA1 glutamate receptor, ionotropic, AMPA 1 0.776384
GRIA3 glutamate receptor, ionotropic, AMPA 3 0.761342
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.757707
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 0.741416
IQSEC2 IQ motif and Sec7 domain 2 0.731076
GRM1 glutamate receptor, metabotropic 1 0.71857
CALB1 calbindin 1, 28kDa 0.71768
SLC6A5 solute carrier family 6 (neurotransmitter transporter), member 5 0.709251
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 0.700863
CBLN1 cerebellin 1 precursor 0.696905
MRO maestro 0.670725
SYN1 synapsin I 0.666827
LRFN4 leucine rich repeat and fibronectin type III domain containing 4 0.65388
GRIA2 glutamate receptor, ionotropic, AMPA 2 0.648291
KIRREL2 kin of IRRE like 2 (Drosophila) 0.643572
UPB1 ureidopropionase, beta 0.640573
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 0.634586
SST somatostatin 0.619255
NRXN2 neurexin 2 0.617982
NRG1 neuregulin 1 0.610778
GLRA3 glycine receptor, alpha 3 0.592232
ABAT 4-aminobutyrate aminotransferase 0.588037
COL19A1 collagen, type XIX, alpha 1 0.580922
PTPRT protein tyrosine phosphatase, receptor type, T 0.575912
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.573411
DLG4 discs, large homolog 4 (Drosophila) 0.572578
CCK cholecystokinin 0.569248
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 0.565092
ZDHHC3 zinc finger, DHHC-type containing 3 0.557214
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon 0.545236
ALG10 ALG10, alpha-1,2-glucosyltransferase 0.539883
NTF4 neurotrophin 4 0.536594
NRXN3 neurexin 3 0.532898
CLCN2 chloride channel, voltage-sensitive 2 0.531258
IQSEC1 IQ motif and Sec7 domain 1 0.527979
MEGF10 multiple EGF-like-domains 10 0.523476
BSN bassoon presynaptic cytomatrix protein 0.521841
IGSF9 immunoglobulin superfamily, member 9 0.503506
SYP synaptophysin 0.492157
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2 0.48287
KLHL1 kelch-like family member 1 0.481258
ZDHHC17 zinc finger, DHHC-type containing 17 0.474018
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.466399
CPLX2 complexin 2 0.461998
GRIP2 glutamate receptor interacting protein 2 0.461199
CBLN2 cerebellin 2 precursor 0.460401
CPLX1 complexin 1 0.447259
CAPS2 calcyphosine 2 0.440916
LRRTM1 leucine rich repeat transmembrane neuronal 1 0.440916
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 0.433407
CADPS2 Ca++-dependent secretion activator 2 0.421212
MSTO1 misato 1, mitochondrial distribution and morphology regulator 0.420428
LYNX1 Ly6/neurotoxin 1 0.416511
MIR203A microRNA 203a 0.413382
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3 0.41143
NPY neuropeptide Y 0.39471
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 0.390841
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 0.389296
RIMS1 regulating synaptic membrane exocytosis 1 0.381969
CLSTN1 calsyntenin 1 0.380429
GDF5 growth differentiation factor 5 0.37966
SYNJ1 synaptojanin 1 0.37045
NTF3 neurotrophin 3 0.365095
SYT11 synaptotagmin XI 0.361277
ACAP3 ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 0.360515
GRIA4 glutamate receptor, ionotropic, AMPA 4 0.356324
NBEA neurobeachin 0.354042
GRM8 glutamate receptor, metabotropic 8 0.352522
HLA-E major histocompatibility complex, class I, E 0.345692
THBS3 thrombospondin 3 0.343799
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 0.342664
CADM1 cell adhesion molecule 1 0.337751
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 0.336996
DACT1 dishevelled-binding antagonist of beta-catenin 1 0.329461
OPRM1 opioid receptor, mu 1 0.326829
KLRC1 killer cell lectin-like receptor subfamily C, member 1 0.321201
TNFRSF4 tumor necrosis factor receptor superfamily, member 4 0.31783
SYN3 synapsin III 0.31596
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.315586
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3 0.311478
CALB2 calbindin 2 0.309613
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 0.308122
UCN2 urocortin 2 0.29994
KIDINS220 kinase D-interacting substrate, 220kDa 0.299197
ADCY2 adenylate cyclase 2 (brain) 0.29623
DMD dystrophin 0.295119
KLRD1 killer cell lectin-like receptor subfamily D, member 1 0.28846
CADM3 cell adhesion molecule 3 0.288091
CNTNAP2 contactin associated protein-like 2 0.287721
TRPA1 transient receptor potential cation channel, subfamily A, member 1 0.282189
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae) 0.280349
NFASC neurofascin 0.277774
GRIP1 glutamate receptor interacting protein 1 0.275202
GRM5 glutamate receptor, metabotropic 5 0.269701
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6 0.267871
LEP leptin 0.266774
NXN nucleoredoxin 0.262025
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7 0.255834
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila) 0.253653
NUTM1 NUT midline carcinoma, family member 1 0.253291
IGLL5 immunoglobulin lambda-like polypeptide 5 0.231315
MAF1 MAF1 homolog (S. cerevisiae) 0.218914
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.218563
GLUD2 glutamate dehydrogenase 2 0.213669
PRDM2 PR domain containing 2, with ZNF domain 0.210203
SGCE sarcoglycan, epsilon 0.203361
MGLL monoglyceride lipase 0.203361
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit 0.201335
EPHA3 EPH receptor A3 0.196999
IL17C interleukin 17C 0.195025
KLRK1 killer cell lectin-like receptor subfamily K, member 1 0.192423
NSF N-ethylmaleimide-sensitive factor 0.18796
CRH corticotropin releasing hormone 0.184853
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.183935
SLC30A3 solute carrier family 30 (zinc transporter), member 3 0.166643
DLC1 DLC1 Rho GTPase activating protein 0.16342
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D 0.162763
ERBB4 erb-b2 receptor tyrosine kinase 4 0.158882
MCF2 MCF.2 cell line derived transforming sequence 0.158315
MCM8 minichromosome maintenance complex component 8 0.158315
WNT7A wingless-type MMTV integration site family, member 7A 0.158129
HAP1 huntingtin-associated protein 1 0.15776