inflammatory bowel disease Gene Set

Dataset GWASdb SNP-Disease Associations
Category disease or phenotype associations
Type disease
Description An intestinal disease characterized by inflammation located_in all parts of digestive tract. (Human Disease Ontology, DOID_0050589)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/DOID:0050589
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Genes

317 genes associated with the disease inflammatory bowel disease in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.

Symbol Name Standardized Value
IL23R interleukin 23 receptor 3.30977
CARD9 caspase recruitment domain family, member 9 2.62533
C5ORF56 chromosome 5 open reading frame 56 2.5872
MST1 macrophage stimulating 1 2.53168
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 2.39626
ZNF300 zinc finger protein 300 2.3845
C1ORF106 chromosome 1 open reading frame 106 2.31657
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 2.30751
IL1RL1 interleukin 1 receptor-like 1 2.29972
PUS10 pseudouridylate synthase 10 2.29954
PTPN2 protein tyrosine phosphatase, non-receptor type 2 2.17705
CCHCR1 coiled-coil alpha-helical rod protein 1 2.12144
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) 2.11633
ZGPAT zinc finger, CCCH-type with G patch domain 2.11291
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 2.06605
IL27 interleukin 27 2.06126
GPR35 G protein-coupled receptor 35 2.05009
CDC37 cell division cycle 37 1.94711
ZMIZ1 zinc finger, MIZ-type containing 1 1.93944
IL18RAP interleukin 18 receptor accessory protein 1.91365
UBE2L3 ubiquitin-conjugating enzyme E2L 3 1.8787
RORC RAR-related orphan receptor C 1.85286
SMAD3 SMAD family member 3 1.84431
ADCY3 adenylate cyclase 3 1.84431
TSPAN14 tetraspanin 14 1.83526
PARK7 parkinson protein 7 1.83309
FEN1 flap structure-specific endonuclease 1 1.82268
FLJ31356 uncharacterized protein FLJ31356 1.81431
NOD2 nucleotide-binding oligomerization domain containing 2 1.78394
TTL tubulin tyrosine ligase 1.77455
GPR65 G protein-coupled receptor 65 1.77455
GPR183 G protein-coupled receptor 183 1.77455
HORMAD2 HORMA domain containing 2 1.76581
NDFIP1 Nedd4 family interacting protein 1 1.75993
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 1.74243
TRAF3IP2-AS1 TRAF3IP2 antisense RNA 1 1.74
KIAA1109 KIAA1109 1.71806
SLC9A4 solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4 1.71432
ERAP2 endoplasmic reticulum aminopeptidase 2 1.70502
DENND1B DENN/MADD domain containing 1B 1.69911
CPSF3L cleavage and polyadenylation specific factor 3-like 1.69911
TUBD1 tubulin, delta 1 1.69672
CD6 CD6 molecule 1.69672
ZNF831 zinc finger protein 831 1.69467
IL18R1 interleukin 18 receptor 1 1.67669
PNKD paroxysmal nonkinesigenic dyskinesia 1.6622
THADA thyroid adenoma associated 1.64426
STAT4 signal transducer and activator of transcription 4 1.60875
RIT1 Ras-like without CAAX 1 1.59102
MAP3K8 mitogen-activated protein kinase kinase kinase 8 1.59102
DOCK4 dedicator of cytokinesis 4 1.5865
CRTC3 CREB regulated transcription coactivator 3 1.57873
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 1.55738
LSP1 lymphocyte-specific protein 1 1.54533
SNX20 sorting nexin 20 1.53999
IL2RA interleukin 2 receptor, alpha 1.53704
TM9SF4 transmembrane 9 superfamily protein member 4 1.52524
LPXN leupaxin 1.52067
C10ORF55 chromosome 10 open reading frame 55 1.52067
PRKCB protein kinase C, beta 1.50906
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 1.50906
ATXN2L ataxin 2-like 1.48714
HNF1A HNF1 homeobox A 1.47287
APEH acylaminoacyl-peptide hydrolase 1.4457
HDAC7 histone deacetylase 7 1.43537
IPMK inositol polyphosphate multikinase 1.43537
DAP death-associated protein 1.42467
DUSP16 dual specificity phosphatase 16 1.42467
NKX2-3 NK2 homeobox 3 1.40859
LOC100506403 uncharacterized LOC100506403 1.39396
RGS14 regulator of G-protein signaling 14 1.39396
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 1.34065
SBNO2 strawberry notch homolog 2 (Drosophila) 1.31953
OTUD3 OTU deubiquitinase 3 1.31785
LACC1 laccase (multicopper oxidoreductase) domain containing 1 1.30755
BSN bassoon presynaptic cytomatrix protein 1.27089
IL1R1 interleukin 1 receptor, type I 1.25589
RTEL1 regulator of telomere elongation helicase 1 1.22625
CCNY cyclin Y 1.15433
BTNL2 butyrophilin-like 2 1.14143
IL1RL2 interleukin 1 receptor-like 2 1.14071
NR5A2 nuclear receptor subfamily 5, group A, member 2 1.11765
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 1.10965
GNA12 guanine nucleotide binding protein (G protein) alpha 12 1.07854
KSR1 kinase suppressor of ras 1 1.06272
SP140 SP140 nuclear body protein 1.05823
PLCL1 phospholipase C-like 1 1.05023
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) 1.0283
FUT2 fucosyltransferase 2 (secretor status included) 0.958374
AMT aminomethyltransferase 0.914431
LOC285626 uncharacterized LOC285626 0.805161
SCAMP3 secretory carrier membrane protein 3 0.742156
IL10 interleukin 10 0.668836
TYK2 tyrosine kinase 2 0.668836
FGFR1OP FGFR1 oncogene partner 0.668836
MAML2 mastermind-like 2 (Drosophila) 0.662755
GSDMB gasdermin B 0.65263
BANK1 B-cell scaffold protein with ankyrin repeats 1 0.64645
ATG16L2 autophagy related 16-like 2 (S. cerevisiae) 0.641733
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.63024
ANKRD55 ankyrin repeat domain 55 0.63024
RNASET2 ribonuclease T2 0.615118
CLN3 ceroid-lipofuscinosis, neuronal 3 0.593633
TMEM258 transmembrane protein 258 0.593633
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.571954
GCKR glucokinase (hexokinase 4) regulator 0.570922
PPP5C protein phosphatase 5, catalytic subunit 0.534605
RSPO3 R-spondin 3 0.516381
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8 0.505133
KIF21B kinesin family member 21B 0.500404
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 0.498333
ITLN1 intelectin 1 (galactofuranose binding) 0.496271
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 0.487532
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.482709
JAZF1 JAZF zinc finger 1 0.482571
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.481235
SLC22A23 solute carrier family 22, member 23 0.47932
ZNF365 zinc finger protein 365 0.47932
PER3 period circadian clock 3 0.47932
ELF1 E74-like factor 1 (ets domain transcription factor) 0.478563
TEX9 testis expressed 9 0.478081
SFMBT1 Scm-like with four mbt domains 1 0.477278
MLN motilin 0.477278
NKD1 naked cuticle homolog 1 (Drosophila) 0.473004
SLAIN2 SLAIN motif family, member 2 0.472904
DSCAM Down syndrome cell adhesion molecule 0.470599
ZFP90 ZFP90 zinc finger protein 0.470241
TCF4 transcription factor 4 0.470241
SKAP2 src kinase associated phosphoprotein 2 0.470241
PTRF polymerase I and transcript release factor 0.470241
CYLD cylindromatosis (turban tumor syndrome) 0.469901
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.469122
IL7R interleukin 7 receptor 0.468362
IL17REL interleukin 17 receptor E-like 0.468362
JAK2 Janus kinase 2 0.467809
TCTA T-cell leukemia translocation altered 0.46057
LINC00284 long intergenic non-protein coding RNA 284 0.459167
OSBPL3 oxysterol binding protein-like 3 0.456271
C1ORF141 chromosome 1 open reading frame 141 0.456271
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 0.455618
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 0.453563
NOTCH1 notch 1 0.453243
LYRM4 LYR motif containing 4 0.450891
RHOA ras homolog family member A 0.450399
FCHSD2 FCH and double SH3 domains 2 0.44927
NICN1 nicolin 1 0.448787
IL26 interleukin 26 0.446685
BCAS3 breast carcinoma amplified sequence 3 0.446389
CD244 CD244 molecule, natural killer cell receptor 2B4 0.444585
PSORS1C3 psoriasis susceptibility 1 candidate 3 (non-protein coding) 0.442803
ADAD1 adenosine deaminase domain containing 1 (testis-specific) 0.439762
GRK5 G protein-coupled receptor kinase 5 0.439047
C6ORF10 chromosome 6 open reading frame 10 0.435443
USP4 ubiquitin specific peptidase 4 (proto-oncogene) 0.435259
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6 0.434302
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1 0.431091
HDAC9 histone deacetylase 9 0.430311
LOC285484 uncharacterized LOC285484 0.426384
NELL1 NEL-like 1 (chicken) 0.425585
CIITA class II, major histocompatibility complex, transactivator 0.425585
ITGA9 integrin, alpha 9 0.425463
BSN-AS2 BSN antisense RNA 2 (head to head) 0.424829
HLA-DOB major histocompatibility complex, class II, DO beta 0.42479
WDR78 WD repeat domain 78 0.423412
CDC42SE2 CDC42 small effector 2 0.42331
WDR27 WD repeat domain 27 0.422682
CAMK2G calcium/calmodulin-dependent protein kinase II gamma 0.422395
LDLRAD3 low density lipoprotein receptor class A domain containing 3 0.421693
IL3 interleukin 3 0.421663
MYH16 myosin, heavy chain 16 pseudogene 0.420891
CARD8 caspase recruitment domain family, member 8 0.419531
SATB2 SATB homeobox 2 0.419335
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 0.417528
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 0.417062
TMEM47 transmembrane protein 47 0.416993
MIER1 mesoderm induction early response 1, transcriptional regulator 0.416767
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.416723
IQCB1 IQ motif containing B1 0.41637
ACSL6 acyl-CoA synthetase long-chain family member 6 0.416154
ZDHHC23 zinc finger, DHHC-type containing 23 0.414949
LAMB1 laminin, beta 1 0.414949
ZBTB16 zinc finger and BTB domain containing 16 0.413472
F11 coagulation factor XI 0.413454
CAPZB capping protein (actin filament) muscle Z-line, beta 0.413127
CCDC169 coiled-coil domain containing 169 0.412791
GPSM3 G-protein signaling modulator 3 0.412382
LOC728637 0.412222
RUNX3 runt-related transcription factor 3 0.411526
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.411376
FAM92B family with sequence similarity 92, member B 0.410722
ANKRD44 ankyrin repeat domain 44 0.410372
ZNF664-FAM101A filamin-interacting protein FAM101A 0.410235
TRAIP TRAF interacting protein 0.408935
CCDC38 coiled-coil domain containing 38 0.407725
FOS FBJ murine osteosarcoma viral oncogene homolog 0.407594
CAMKV CaM kinase-like vesicle-associated 0.406111
RALGDS ral guanine nucleotide dissociation stimulator 0.404869
IP6K1 inositol hexakisphosphate kinase 1 0.403924
AKAP13 A kinase (PRKA) anchor protein 13 0.402198
NCF4 neutrophil cytosolic factor 4, 40kDa 0.401752
SUGT1P3 SUGT1 pseudogene 3 0.401752
PRIM2 primase, DNA, polypeptide 2 (58kDa) 0.401319
FNIP1 folliculin interacting protein 1 0.401149
ZFPM2 zinc finger protein, FOG family member 2 0.400489
TTC6 tetratricopeptide repeat domain 6 0.400489
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.400248
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.399934
BATF basic leucine zipper transcription factor, ATF-like 0.397903
IL1R2 interleukin 1 receptor, type II 0.397836
BRD2 bromodomain containing 2 0.397436
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) 0.39654
MUC21 mucin 21, cell surface associated 0.39654
MST1R macrophage stimulating 1 receptor 0.395688
PRPF18 pre-mRNA processing factor 18 0.39481
RADIL Ras association and DIL domains 0.394164
FREM2 FRAS1 related extracellular matrix protein 2 0.392942
MON1A MON1 secretory trafficking family member A 0.391802
ZNF532 zinc finger protein 532 0.391529
COL11A2 collagen, type XI, alpha 2 0.390375
FDPS farnesyl diphosphate synthase 0.38878
ESRRG estrogen-related receptor gamma 0.388643
ROR1 receptor tyrosine kinase-like orphan receptor 1 0.387324
RHOU ras homolog family member U 0.38703
NOTCH4 notch 4 0.386783
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.38662
DZIP1 DAZ interacting zinc finger protein 1 0.386338
EPHB2 EPH receptor B2 0.386219
COL23A1 collagen, type XXIII, alpha 1 0.383941
TET2 tet methylcytosine dioxygenase 2 0.383826
CHSY3 chondroitin sulfate synthase 3 0.383673
KAZN kazrin, periplakin interacting protein 0.383297
SPON1 spondin 1, extracellular matrix protein 0.382964
SORCS2 sortilin-related VPS10 domain containing receptor 2 0.382928
TNXB tenascin XB 0.382387
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F 0.382281
ATRNL1 attractin-like 1 0.381863
CCDC91 coiled-coil domain containing 91 0.381691
SCN3A sodium channel, voltage gated, type III alpha subunit 0.38142
HLA-DPB2 major histocompatibility complex, class II, DP beta 2 (pseudogene) 0.380629
CLSTN2 calsyntenin 2 0.380436
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 0.379778
VAMP3 vesicle-associated membrane protein 3 0.377991
MACROD2 MACRO domain containing 2 0.377172
RNF5 ring finger protein 5, E3 ubiquitin protein ligase 0.373642
FBXL13 F-box and leucine-rich repeat protein 13 0.373598
AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1 0.373576
HPSE2 heparanase 2 (inactive) 0.373315
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.372658
SORCS1 sortilin-related VPS10 domain containing receptor 1 0.371964
BCL9 B-cell CLL/lymphoma 9 0.371085
POU5F1 POU class 5 homeobox 1 0.370951
LDLRAD4 low density lipoprotein receptor class A domain containing 4 0.370753
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 0.365609
TCF19 transcription factor 19 0.364588
AGER advanced glycosylation end product-specific receptor 0.363486
TAGAP T-cell activation RhoGTPase activating protein 0.362445
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 0.360411
GPC6 glypican 6 0.359312
MB21D2 Mab-21 domain containing 2 0.358275
KAT6B K(lysine) acetyltransferase 6B 0.358275
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.356673
CLUL1 clusterin-like 1 (retinal) 0.352561
ARHGAP19 Rho GTPase activating protein 19 0.352561
GNG2 guanine nucleotide binding protein (G protein), gamma 2 0.352561
VSTM4 V-set and transmembrane domain containing 4 0.350171
CHD9 chromodomain helicase DNA binding protein 9 0.349873
RAB6B RAB6B, member RAS oncogene family 0.349434
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.348723
ZNF311 zinc finger protein 311 0.348037
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.348037
TEX41 testis expressed 41 (non-protein coding) 0.348037
CSMD1 CUB and Sushi multiple domains 1 0.348037
CD36 CD36 molecule (thrombospondin receptor) 0.34673
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 0.345865
SULF2 sulfatase 2 0.345804
MTMR3 myotubularin related protein 3 0.344977
QPCT glutaminyl-peptide cyclotransferase 0.34435
CFB complement factor B 0.343366
NPAS3 neuronal PAS domain protein 3 0.34163
GDPD4 glycerophosphodiester phosphodiesterase domain containing 4 0.339425
CCDC85A coiled-coil domain containing 85A 0.338905
HLA-DRA major histocompatibility complex, class II, DR alpha 0.338447
FHIT fragile histidine triad 0.338397
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.338397
MARCH11 membrane-associated ring finger (C3HC4) 11 0.338196
SRPK1 SRSF protein kinase 1 0.337655
COL19A1 collagen, type XIX, alpha 1 0.336936
SLC14A2 solute carrier family 14 (urea transporter), member 2 0.336013
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 0.333286
MIPEP mitochondrial intermediate peptidase 0.332653
FERMT1 fermitin family member 1 0.332304
PDE8A phosphodiesterase 8A 0.332266
TEK TEK tyrosine kinase, endothelial 0.331511
HLA-C major histocompatibility complex, class I, C 0.330354
LPPR5 lipid phosphate phosphatase-related protein type 5 0.329388
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.329053
NOS2 nitric oxide synthase 2, inducible 0.328269
NPSR1 neuropeptide S receptor 1 0.328077
DNAH11 dynein, axonemal, heavy chain 11 0.328077
COL25A1 collagen, type XXV, alpha 1 0.327824
CNTNAP5 contactin associated protein-like 5 0.327605
GRM5 glutamate receptor, metabotropic 5 0.327449
SCUBE3 signal peptide, CUB domain, EGF-like 3 0.327295
ITGB6 integrin, beta 6 0.327142
FAM188A family with sequence similarity 188, member A 0.325665
AGBL4 ATP/GTP binding protein-like 4 0.325665
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A 0.325382
RAB12 RAB12, member RAS oncogene family 0.325063
PPP2R2B protein phosphatase 2, regulatory subunit B, beta 0.324739
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 0.323885
MYO5B myosin VB 0.323179
WDR46 WD repeat domain 46 0.323119
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.322878
SIDT1 SID1 transmembrane family, member 1 0.322287
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.322287
SGCZ sarcoglycan, zeta 0.321425
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.321425