inflammatory bowel disease Gene Set

Dataset DISEASES Experimental Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description An intestinal disease characterized by inflammation located_in all parts of digestive tract. (Human Disease Ontology, DOID_0050589)
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Genes

321 genes associated with the disease inflammatory bowel disease in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
IKZF3 IKAROS family zinc finger 3 (Aiolos) 1.96161
ZMIZ1 zinc finger, MIZ-type containing 1 1.77331
SNX20 sorting nexin 20 1.71882
HLA-C major histocompatibility complex, class I, C 1.66741
CCL7 chemokine (C-C motif) ligand 7 1.62569
ZGPAT zinc finger, CCCH-type with G patch domain 1.52269
IL27 interleukin 27 1.43901
MUC19 mucin 19, oligomeric 1.41058
RNASET2 ribonuclease T2 1.40682
CARD9 caspase recruitment domain family, member 9 1.31515
SMAD3 SMAD family member 3 1.31515
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 1.2894
CDC37 cell division cycle 37 1.27521
APEH acylaminoacyl-peptide hydrolase 1.22898
NR5A2 nuclear receptor subfamily 5, group A, member 2 1.22898
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 1.18942
KSR1 kinase suppressor of ras 1 1.18387
IFNG interferon, gamma 1.17894
SP140 SP140 nuclear body protein 1.17894
CUX2 cut-like homeobox 2 1.17894
UBE2L3 ubiquitin-conjugating enzyme E2L 3 1.17894
ATF6B activating transcription factor 6 beta 1.17894
TNXB tenascin XB 1.17894
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) 1.14929
PRM1 protamine 1 1.14929
RORC RAR-related orphan receptor C 1.12703
C11ORF30 chromosome 11 open reading frame 30 1.11998
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G 1.11998
ADCY3 adenylate cyclase 3 1.1139
TSPAN14 tetraspanin 14 1.09962
FUT2 fucosyltransferase 2 (secretor status included) 1.09588
FEN1 flap structure-specific endonuclease 1 1.07383
RSBN1 round spermatid basic protein 1 1.07383
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.07383
AMZ1 archaelysin family metallopeptidase 1 1.06123
FOSL2 FOS-like antigen 2 1.06123
GNA12 guanine nucleotide binding protein (G protein) alpha 12 1.06123
AMT aminomethyltransferase 1.06123
SLC7A10 solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10 1.0394
IKZF1 IKAROS family zinc finger 1 (Ikaros) 1.03485
THEMIS thymocyte selection associated 1.03105
GPR183 G protein-coupled receptor 183 1.00628
THADA thyroid adenoma associated 1.00628
PUS10 pseudouridylate synthase 10 1.00628
UBAC2 UBA domain containing 2 1.00628
GPR65 G protein-coupled receptor 65 1.00628
HORMAD2 HORMA domain containing 2 0.995303
MTMR3 myotubularin related protein 3 0.995303
NXPE1 neurexophilin and PC-esterase domain family, member 1 0.982645
CD40 CD40 molecule, TNF receptor superfamily member 5 0.965481
TRAF3IP2 TRAF3 interacting protein 2 0.965481
PLCL1 phospholipase C-like 1 0.945428
EPO erythropoietin 0.945428
SCAMP3 secretory carrier membrane protein 3 0.945428
LACC1 laccase (multicopper oxidoreductase) domain containing 1 0.945428
KIAA1109 KIAA1109 0.932337
DENND1B DENN/MADD domain containing 1B 0.901326
CPSF3L cleavage and polyadenylation specific factor 3-like 0.901326
TUBD1 tubulin, delta 1 0.897589
CD6 CD6 molecule 0.897589
ZNF831 zinc finger protein 831 0.894262
TYK2 tyrosine kinase 2 0.894262
FGFR1OP FGFR1 oncogene partner 0.894262
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.872896
IL18RAP interleukin 18 receptor accessory protein 0.872896
BANK1 B-cell scaffold protein with ankyrin repeats 1 0.872896
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 0.85991
IL1R1 interleukin 1 receptor, type I 0.85991
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.85991
PNKD paroxysmal nonkinesigenic dyskinesia 0.850113
PTOV1 prostate tumor overexpressed 1 0.850113
ANKRD55 ankyrin repeat domain 55 0.850113
TMBIM1 transmembrane BAX inhibitor motif containing 1 0.850113
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.850113
DAP death-associated protein 0.835734
MAMSTR MEF2 activating motif and SAP domain containing transcriptional regulator 0.830123
AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.817078
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta 0.817078
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) 0.817078
SORCS2 sortilin-related VPS10 domain containing receptor 2 0.817078
CLN3 ceroid-lipofuscinosis, neuronal 3 0.790827
NOTCH2 notch 2 0.790827
TAGAP T-cell activation RhoGTPase activating protein 0.790827
TMEM258 transmembrane protein 258 0.790827
RNF186 ring finger protein 186 0.790827
STAT4 signal transducer and activator of transcription 4 0.774217
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4 0.7623
GCKR glucokinase (hexokinase 4) regulator 0.752991
ZPBP2 zona pellucida binding protein 2 0.752991
MAP3K8 mitogen-activated protein kinase kinase kinase 8 0.745324
RIT1 Ras-like without CAAX 1 0.745324
ICOSLG inducible T-cell co-stimulator ligand 0.745324
FCAR Fc fragment of IgA receptor 0.738873
GPR35 G protein-coupled receptor 35 0.73332
KPNA7 karyopherin alpha 7 (importin alpha 8) 0.728541
CRTC3 CREB regulated transcription coactivator 3 0.728541
CXCR2 chemokine (C-X-C motif) receptor 2 0.724323
LSP1 lymphocyte-specific protein 1 0.724323
ZNF365 zinc finger protein 365 0.724323
ERAP2 endoplasmic reticulum aminopeptidase 2 0.724323
PPP5C protein phosphatase 5, catalytic subunit 0.69843
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.69843
RAD51B RAD51 paralog B 0.69843
VEGFA vascular endothelial growth factor A 0.69843
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.69843
FIBP fibroblast growth factor (acidic) intracellular binding protein 0.682635
LRRK2 leucine-rich repeat kinase 2 0.682635
RSPO3 R-spondin 3 0.670996
HINT1 histidine triad nucleotide binding protein 1 0.670996
SLMAP sarcolemma associated protein 0.670996
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 0.661797
AKAP11 A kinase (PRKA) anchor protein 11 0.661797
TMEM174 transmembrane protein 174 0.65413
TM9SF4 transmembrane 9 superfamily protein member 4 0.65413
PRDX5 peroxiredoxin 5 0.65413
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.65413
LPXN leupaxin 0.647573
PLAU plasminogen activator, urokinase 0.647573
C10ORF55 chromosome 10 open reading frame 55 0.647573
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 0.63666
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.63666
ITLN1 intelectin 1 (galactofuranose binding) 0.63207
CEP72 centrosomal protein 72kDa 0.63207
PTGER4 prostaglandin E receptor 4 (subtype EP4) 0.63207
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 0.63207
NRG3 neuregulin 3 0.63207
TRAM2 translocation associated membrane protein 2 0.63207
PRKCB protein kinase C, beta 0.63207
CTIF CBP80/20-dependent translation initiation factor 0.63207
SLC39A11 solute carrier family 39, member 11 0.602429
NUP153 nucleoporin 153kDa 0.602429
NDFIP1 Nedd4 family interacting protein 1 0.602429
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8 0.602429
ACSL6 acyl-CoA synthetase long-chain family member 6 0.602429
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 0.602429
GIPC2 GIPC PDZ domain containing family, member 2 0.58494
IL2RA interleukin 2 receptor, alpha 0.58494
FAM213B family with sequence similarity 213, member B 0.58494
CCL25 chemokine (C-C motif) ligand 25 0.58494
MST1 macrophage stimulating 1 0.572184
AUH AU RNA binding protein/enoyl-CoA hydratase 0.572184
JAZF1 JAZF zinc finger 1 0.572184
CYLD cylindromatosis (turban tumor syndrome) 0.572184
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) 0.572184
PARK7 parkinson protein 7 0.561725
C7ORF72 chromosome 7 open reading frame 72 0.561725
CD226 CD226 molecule 0.561725
SBNO2 strawberry notch homolog 2 (Drosophila) 0.552621
FBLN2 fibulin 2 0.552621
TMEM17 transmembrane protein 17 0.544585
NXN nucleoredoxin 0.544585
OTUD3 OTU deubiquitinase 3 0.544585
PER3 period circadian clock 3 0.544585
CXCR5 chemokine (C-X-C motif) receptor 5 0.544585
TUBGCP4 tubulin, gamma complex associated protein 4 0.537125
IPMK inositol polyphosphate multikinase 0.537125
ELF1 E74-like factor 1 (ets domain transcription factor) 0.537125
HDAC7 histone deacetylase 7 0.537125
SLC43A3 solute carrier family 43, member 3 0.537125
TEX9 testis expressed 9 0.5306
TSPAN18 tetraspanin 18 0.5306
PRDM1 PR domain containing 1, with ZNF domain 0.52461
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.52461
OSGIN2 oxidative stress induced growth inhibitor family member 2 0.52461
IL10 interleukin 10 0.52461
DUSP16 dual specificity phosphatase 16 0.52461
MAML2 mastermind-like 2 (Drosophila) 0.52461
C1ORF141 chromosome 1 open reading frame 141 0.52461
SFMBT1 Scm-like with four mbt domains 1 0.52461
NKX2-3 NK2 homeobox 3 0.52461
WNT2 wingless-type MMTV integration site family member 2 0.52461
AK5 adenylate kinase 5 0.52461
IL23R interleukin 23 receptor 0.52461
SPRED2 sprouty-related, EVH1 domain containing 2 0.486425
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1 0.486425
TMEM135 transmembrane protein 135 0.486425
RGS14 regulator of G-protein signaling 14 0.486425
SBSPON somatomedin B and thrombospondin, type 1 domain containing 0.486425
PTGER3 prostaglandin E receptor 3 (subtype EP3) 0.486425
EIF6 eukaryotic translation initiation factor 6 0.486425
HOXA13 homeobox A13 0.486425
PHACTR2 phosphatase and actin regulator 2 0.486425
FAP fibroblast activation protein, alpha 0.486425
IRF5 interferon regulatory factor 5 0.486425
NKD1 naked cuticle homolog 1 (Drosophila) 0.486425
SLCO6A1 solute carrier organic anion transporter family, member 6A1 0.486425
SLAIN2 SLAIN motif family, member 2 0.486425
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 0.486425
EP300 E1A binding protein p300 0.464771
HHEX hematopoietically expressed homeobox 0.464771
SKAP2 src kinase associated phosphoprotein 2 0.464771
GSDMB gasdermin B 0.464771
CXCL5 chemokine (C-X-C motif) ligand 5 0.464771
PTPN2 protein tyrosine phosphatase, non-receptor type 2 0.464771
ZFP90 ZFP90 zinc finger protein 0.464771
RGS18 regulator of G-protein signaling 18 0.464771
IL7R interleukin 7 receptor 0.449873
CDH3 cadherin 3, type 1, P-cadherin (placental) 0.449873
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D 0.449873
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.438544
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.438544
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) 0.429338
FBXO9 F-box protein 9 0.414708
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.403461
SLC26A3 solute carrier family 26 (anion exchanger), member 3 0.403461
WNT4 wingless-type MMTV integration site family, member 4 0.403461
C5ORF56 chromosome 5 open reading frame 56 0.403461
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18 0.368757
NUPL2 nucleoporin like 2 0.368757
PTMAP5 prothymosin, alpha pseudogene 5 0.368757
PHOX2B paired-like homeobox 2b 0.368757
IL26 interleukin 26 0.368757
ZNF767P zinc finger family member 767, pseudogene 0.368757
MRGPRX4 MAS-related GPR, member X4 0.368757
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 0.368757
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 0.368757
KIF21B kinesin family member 21B 0.368757
IL17REL interleukin 17 receptor E-like 0.368757
NOTCH4 notch 4 0.345945
IL3 interleukin 3 0.345945
HMHB1 histocompatibility (minor) HB-1 0.345945
TCTA T-cell leukemia translocation altered 0.345945
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.327313
ZNF300 zinc finger protein 300 0.327313
FCHSD2 FCH and double SH3 domains 2 0.327313
NICN1 nicolin 1 0.327313
LYRM4 LYR motif containing 4 0.327313
RHOA ras homolog family member A 0.327313
IRGM immunity-related GTPase family, M 0.327313
CUL2 cullin 2 0.327313
NELL1 NEL-like 1 (chicken) 0.311576
BSN bassoon presynaptic cytomatrix protein 0.311576
BCAS3 breast carcinoma amplified sequence 3 0.311576
AQP12B aquaporin 12B 0.297866
CAMK1G calcium/calmodulin-dependent protein kinase IG 0.285417
POU5F1 POU class 5 homeobox 1 0.285417
C2CD3 C2 calcium-dependent domain containing 3 0.285417
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) 0.274608
PRRT1 proline-rich transmembrane protein 1 0.264872
ADAD1 adenosine deaminase domain containing 1 (testis-specific) 0.264872
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.256228
GRK5 G protein-coupled receptor kinase 5 0.256228
RAB32 RAB32, member RAS oncogene family 0.256228
JAK2 Janus kinase 2 0.256228
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.256228
C1ORF106 chromosome 1 open reading frame 106 0.256228
FAM19A1 family with sequence similarity 19 (chemokine (C-C motif)-like), member A1 0.256228
UTS2 urotensin 2 0.256228
INSL4 insulin-like 4 (placenta) 0.256228
F11 coagulation factor XI 0.256228
USP4 ubiquitin specific peptidase 4 (proto-oncogene) 0.256228
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 0.256228
NOD2 nucleotide-binding oligomerization domain containing 2 0.256228
DLD dihydrolipoamide dehydrogenase 0.256228
SLC36A4 solute carrier family 36 (proton/amino acid symporter), member 4 0.256228
SLC22A23 solute carrier family 22, member 23 0.256228
TXNL4A thioredoxin-like 4A 0.256228
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.197766
C14ORF177 chromosome 14 open reading frame 177 0.197766
HLA-A major histocompatibility complex, class I, A 0.197766
EDN3 endothelin 3 0.197766
HDAC9 histone deacetylase 9 0.197766
TMEM170A transmembrane protein 170A 0.197766
IRF1 interferon regulatory factor 1 0.197766
TSKU tsukushi, small leucine rich proteoglycan 0.197766
CCL2 chemokine (C-C motif) ligand 2 0.197766
MRPS22 mitochondrial ribosomal protein S22 0.197766
GJB2 gap junction protein, beta 2, 26kDa 0.15771
MYH13 myosin, heavy chain 13, skeletal muscle 0.15771
ACBD3 acyl-CoA binding domain containing 3 0.15771
RBM26 RNA binding motif protein 26 0.15771
CIITA class II, major histocompatibility complex, transactivator 0.15771
AIF1 allograft inflammatory factor 1 0.15771
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 0.15771
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 0.15771
RSPO2 R-spondin 2 0.15771
CCNY cyclin Y 0.126165
UST uronyl-2-sulfotransferase 0.126165
WDR78 WD repeat domain 78 0.126165
BPIFB4 BPI fold containing family B, member 4 0.126165
PCDH9 protocadherin 9 0.126165
MKX mohawk homeobox 0.126165
CDC42SE2 CDC42 small effector 2 0.126165
CARD8 caspase recruitment domain family, member 8 0.100789
ZP2 zona pellucida glycoprotein 2 (sperm receptor) 0.100789
BATF basic leucine zipper transcription factor, ATF-like 0.100789
SATB2 SATB homeobox 2 0.100789
TMEM47 transmembrane protein 47 0.080593
IL19 interleukin 19 0.080593
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.080593
IQCB1 IQ motif containing B1 0.080593
TET2 tet methylcytosine dioxygenase 2 0.080593
HLA-DOB major histocompatibility complex, class II, DO beta 0.080593
CLK3 CDC-like kinase 3 0.080593
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.080593
MIER1 mesoderm induction early response 1, transcriptional regulator 0.080593
CD28 CD28 molecule 0.080593
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa 0.064973
ARID3B AT rich interactive domain 3B (BRIGHT-like) 0.064973
MUSK muscle, skeletal, receptor tyrosine kinase 0.064973
FOXP2 forkhead box P2 0.064973
ADCK3 aarF domain containing kinase 3 0.064973
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 0.064973
PTRF polymerase I and transcript release factor 0.064973
SH3BP4 SH3-domain binding protein 4 0.064973
FBXL17 F-box and leucine-rich repeat protein 17 0.064973
LAMB1 laminin, beta 1 0.064973
GRP gastrin-releasing peptide 0.052255
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.052255
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.052255
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.052255
IL12B interleukin 12B 0.052255
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.052255
GPC5 glypican 5 0.052255
CDH13 cadherin 13 0.052255
KIAA1467 KIAA1467 0.043246
TRIM27 tripartite motif containing 27 0.043246
RUNX3 runt-related transcription factor 3 0.043246
BMPER BMP binding endothelial regulator 0.043246
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20 0.043246
FAM92B family with sequence similarity 92, member B 0.035343