indometacin-453 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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199 genes differentially expressed following the indometacin-453 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AATK apoptosis-associated tyrosine kinase
ACOT11 acyl-CoA thioesterase 11
ACTC1 actin, alpha, cardiac muscle 1
ADAM5 ADAM metallopeptidase domain 5 (pseudogene)
AFF1 AF4/FMR2 family, member 1
AKR1C2 aldo-keto reductase family 1, member C2
ALCAM activated leukocyte cell adhesion molecule
ATN1 atrophin 1
ATXN2 ataxin 2
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BLK BLK proto-oncogene, Src family tyrosine kinase
C10ORF76 chromosome 10 open reading frame 76
C14ORF79 chromosome 14 open reading frame 79
C1ORF105 chromosome 1 open reading frame 105
C20ORF27 chromosome 20 open reading frame 27
C5ORF45 chromosome 5 open reading frame 45
CDC25A cell division cycle 25A
CHMP1B charged multivesicular body protein 1B
CMTR1 cap methyltransferase 1
COL18A1 collagen, type XVIII, alpha 1
COL5A3 collagen, type V, alpha 3
CPB1 carboxypeptidase B1 (tissue)
CSH2 chorionic somatomammotropin hormone 2
CXCL12 chemokine (C-X-C motif) ligand 12
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYR61 cysteine-rich, angiogenic inducer, 61
DENND3 DENN/MADD domain containing 3
DLAT dihydrolipoamide S-acetyltransferase
DMTN dematin actin binding protein
EFNB3 ephrin-B3
EGFR epidermal growth factor receptor
EGR3 early growth response 3
ELF2 E74-like factor 2 (ets domain transcription factor)
FAM110B family with sequence similarity 110, member B
FAM188A family with sequence similarity 188, member A
FBLN1 fibulin 1
FOSL2 FOS-like antigen 2
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FRAT1 frequently rearranged in advanced T-cell lymphomas 1
GAB2 GRB2-associated binding protein 2
GADD45B growth arrest and DNA-damage-inducible, beta
GP6 glycoprotein VI (platelet)
GPATCH4 G patch domain containing 4
GPATCH8 G patch domain containing 8
GRIP2 glutamate receptor interacting protein 2
GYPB glycophorin B (MNS blood group)
HABP2 hyaluronan binding protein 2
HIST1H4J histone cluster 1, H4j
HLA-G major histocompatibility complex, class I, G
HOXA11 homeobox A11
IL11 interleukin 11
ILK integrin-linked kinase
KHSRP KH-type splicing regulatory protein
LDLR low density lipoprotein receptor
LEMD3 LEM domain containing 3
LGALS8 lectin, galactoside-binding, soluble, 8
MARC2 mitochondrial amidoxime reducing component 2
MNAT1 MNAT CDK-activating kinase assembly factor 1
MOSPD2 motile sperm domain containing 2
MVK mevalonate kinase
MXD4 MAX dimerization protein 4
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NDRG2 NDRG family member 2
NES nestin
NF1 neurofibromin 1
NMT1 N-myristoyltransferase 1
NRGN neurogranin (protein kinase C substrate, RC3)
OTUD4 OTU deubiquitinase 4
PACRG PARK2 co-regulated
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PELP1 proline, glutamate and leucine rich protein 1
PHC1 polyhomeotic homolog 1 (Drosophila)
POLG polymerase (DNA directed), gamma
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
RBL2 retinoblastoma-like 2
RGS3 regulator of G-protein signaling 3
RNF220 ring finger protein 220
SCYL3 SCY1-like 3 (S. cerevisiae)
SFTPC surfactant protein C
SH2B2 SH2B adaptor protein 2
SIDT2 SID1 transmembrane family, member 2
SIGMAR1 sigma non-opioid intracellular receptor 1
SLC45A2 solute carrier family 45, member 2
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SZRD1 SUZ RNA binding domain containing 1
TCF3 transcription factor 3
TCL1A T-cell leukemia/lymphoma 1A
TCP11L1 t-complex 11, testis-specific-like 1
TM6SF1 transmembrane 6 superfamily member 1
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TP53I11 tumor protein p53 inducible protein 11
TRIM14 tripartite motif containing 14
TRIM29 tripartite motif containing 29
TRIM33 tripartite motif containing 33
TTLL4 tubulin tyrosine ligase-like family member 4
VCX2 variable charge, X-linked 2
ZFR zinc finger RNA binding protein
ZNF335 zinc finger protein 335
ZNF654 zinc finger protein 654

decreased expression

Symbol Name
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALPK1 alpha-kinase 1
ARMC4 armadillo repeat containing 4
ASB9 ankyrin repeat and SOCS box containing 9
ATAD2B ATPase family, AAA domain containing 2B
ATXN8OS ATXN8 opposite strand (non-protein coding)
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BCL2L14 BCL2-like 14 (apoptosis facilitator)
BIK BCL2-interacting killer (apoptosis-inducing)
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
C1ORF95 chromosome 1 open reading frame 95
C1QTNF1 C1q and tumor necrosis factor related protein 1
CADPS2 Ca++-dependent secretion activator 2
CAV3 caveolin 3
CCDC94 coiled-coil domain containing 94
CCR8 chemokine (C-C motif) receptor 8
CCS copper chaperone for superoxide dismutase
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CFAP74 cilia and flagella associated protein 74
CPNE7 copine VII
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CYB5R3 cytochrome b5 reductase 3
DAAM1 dishevelled associated activator of morphogenesis 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DBR1 debranching RNA lariats 1
DCAF10 DDB1 and CUL4 associated factor 10
DET1 de-etiolated homolog 1 (Arabidopsis)
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DSCAM Down syndrome cell adhesion molecule
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1
ECM2 extracellular matrix protein 2, female organ and adipocyte specific
ECT2 epithelial cell transforming 2
EFNA4 ephrin-A4
EGFL6 EGF-like-domain, multiple 6
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
EVPL envoplakin
FGD6 FYVE, RhoGEF and PH domain containing 6
FGFBP1 fibroblast growth factor binding protein 1
FOXD1 forkhead box D1
GMEB1 glucocorticoid modulatory element binding protein 1
GOLPH3 golgi phosphoprotein 3 (coat-protein)
GPRASP1 G protein-coupled receptor associated sorting protein 1
GPRC5C G protein-coupled receptor, class C, group 5, member C
GREB1L growth regulation by estrogen in breast cancer-like
GTF2I general transcription factor IIi
HCG9 HLA complex group 9 (non-protein coding)
HCRT hypocretin (orexin) neuropeptide precursor
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
JMJD4 jumonji domain containing 4
KLF15 Kruppel-like factor 15
KRT1 keratin 1, type II
LARP6 La ribonucleoprotein domain family, member 6
LEFTY2 left-right determination factor 2
LIAS lipoic acid synthetase
LYPD1 LY6/PLAUR domain containing 1
MACROD1 MACRO domain containing 1
MAGT1 magnesium transporter 1
MECR mitochondrial trans-2-enoyl-CoA reductase
MGC2889 uncharacterized protein MGC2889
MGST2 microsomal glutathione S-transferase 2
MOB3B MOB kinase activator 3B
MRPL44 mitochondrial ribosomal protein L44
NAV2 neuron navigator 2
NELL2 NEL-like 2 (chicken)
NIP7 NIP7, nucleolar pre-rRNA processing protein
OMG oligodendrocyte myelin glycoprotein
PHF11 PHD finger protein 11
PLA2G12A phospholipase A2, group XIIA
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PQLC2 PQ loop repeat containing 2
PQLC3 PQ loop repeat containing 3
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
PSAT1 phosphoserine aminotransferase 1
RAB33B RAB33B, member RAS oncogene family
RASAL1 RAS protein activator like 1 (GAP1 like)
REC8 REC8 meiotic recombination protein
SDC3 syndecan 3
SIL1 SIL1 nucleotide exchange factor
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC25A24 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SND1-IT1 SND1 intronic transcript 1
T T, brachyury homolog (mouse)
TAGLN transgelin
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TMEM176A transmembrane protein 176A
TMEM38B transmembrane protein 38B
TMEM53 transmembrane protein 53
TMPRSS5 transmembrane protease, serine 5
TSNAXIP1 translin-associated factor X interacting protein 1
UNC93B1 unc-93 homolog B1 (C. elegans)
ZNF354A zinc finger protein 354A
ZNF430 zinc finger protein 430
ZNF652 zinc finger protein 652
ZNHIT2 zinc finger, HIT-type containing 2