indometacin-452 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the indometacin-452 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AK2 adenylate kinase 2
AKR1C3 aldo-keto reductase family 1, member C3
AMBRA1 autophagy/beclin-1 regulator 1
AMIGO2 adhesion molecule with Ig-like domain 2
ANGPTL4 angiopoietin-like 4
ARMC7 armadillo repeat containing 7
ATG13 autophagy related 13
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BMP7 bone morphogenetic protein 7
C7ORF26 chromosome 7 open reading frame 26
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CASP7 caspase 7, apoptosis-related cysteine peptidase
CBX6 chromobox homolog 6
CD2BP2 CD2 (cytoplasmic tail) binding protein 2
CD58 CD58 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDR2L cerebellar degeneration-related protein 2-like
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CIITA class II, major histocompatibility complex, transactivator
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CROT carnitine O-octanoyltransferase
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14
DPP4 dipeptidyl-peptidase 4
EGFR epidermal growth factor receptor
EMC1 ER membrane protein complex subunit 1
EMC9 ER membrane protein complex subunit 9
FABP4 fatty acid binding protein 4, adipocyte
FAF1 Fas (TNFRSF6) associated factor 1
FAM222B family with sequence similarity 222, member B
FAM89B family with sequence similarity 89, member B
FKBP1A FK506 binding protein 1A, 12kDa
FKBPL FK506 binding protein like
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
HBEGF heparin-binding EGF-like growth factor
HIRIP3 HIRA interacting protein 3
HP1BP3 heterochromatin protein 1, binding protein 3
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
IFRD1 interferon-related developmental regulator 1
ITGB5 integrin, beta 5
JMJD4 jumonji domain containing 4
JUN jun proto-oncogene
KTN1 kinectin 1 (kinesin receptor)
LPIN1 lipin 1
LRP1 low density lipoprotein receptor-related protein 1
LUZP1 leucine zipper protein 1
LYPD3 LY6/PLAUR domain containing 3
MYL10 myosin, light chain 10, regulatory
NBL1 neuroblastoma 1, DAN family BMP antagonist
NDRG2 NDRG family member 2
OTUD4 OTU deubiquitinase 4
OVGP1 oviductal glycoprotein 1, 120kDa
PADI1 peptidyl arginine deiminase, type I
PISD phosphatidylserine decarboxylase
PLEKHO2 pleckstrin homology domain containing, family O member 2
PLIN2 perilipin 2
PML promyelocytic leukemia
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha
PPP4C protein phosphatase 4, catalytic subunit
PRKX protein kinase, X-linked
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
QTRT1 queuine tRNA-ribosyltransferase 1
RARG retinoic acid receptor, gamma
RBM10 RNA binding motif protein 10
RIPPLY3 ripply transcriptional repressor 3
RITA1 RBPJ interacting and tubulin associated 1
RPLP2 ribosomal protein, large, P2
RPS2 ribosomal protein S2
RUNX1 runt-related transcription factor 1
SFN stratifin
SIAH2 siah E3 ubiquitin protein ligase 2
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SPATA5L1 spermatogenesis associated 5-like 1
SPTBN1 spectrin, beta, non-erythrocytic 1
SREBF1 sterol regulatory element binding transcription factor 1
SSPN sarcospan
STAG1 stromal antigen 1
TADA3 transcriptional adaptor 3
TMC6 transmembrane channel-like 6
TMED7 transmembrane emp24 protein transport domain containing 7
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TOB2 transducer of ERBB2, 2
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TSKU tsukushi, small leucine rich proteoglycan
TSPAN32 tetraspanin 32
USF2 upstream transcription factor 2, c-fos interacting
USP20 ubiquitin specific peptidase 20
WDR46 WD repeat domain 46
ZBTB40 zinc finger and BTB domain containing 40
ZC3H12A zinc finger CCCH-type containing 12A
ZC3H13 zinc finger CCCH-type containing 13
ZNF768 zinc finger protein 768

decreased expression

Symbol Name
ADRA2B adrenoceptor alpha 2B
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
APOD apolipoprotein D
ART3 ADP-ribosyltransferase 3
ASCC1 activating signal cointegrator 1 complex subunit 1
BCAS4 breast carcinoma amplified sequence 4
CA6 carbonic anhydrase VI
CA9 carbonic anhydrase IX
CD2 CD2 molecule
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon
CHGB chromogranin B
CHRM4 cholinergic receptor, muscarinic 4
CHRM5 cholinergic receptor, muscarinic 5
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
COL5A2 collagen, type V, alpha 2
COLEC12 collectin sub-family member 12
CPB1 carboxypeptidase B1 (tissue)
CRYBB2P1 crystallin, beta B2 pseudogene 1
CTGF connective tissue growth factor
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
DAGLA diacylglycerol lipase, alpha
DENND6B DENN/MADD domain containing 6B
DNASE1L2 deoxyribonuclease I-like 2
ETV7 ets variant 7
FAM46C family with sequence similarity 46, member C
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FZD8 frizzled class receptor 8
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GDF3 growth differentiation factor 3
GPR27 G protein-coupled receptor 27
GUCA2A guanylate cyclase activator 2A (guanylin)
HCRTR2 hypocretin (orexin) receptor 2
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2
IFNA17 interferon, alpha 17
IGFLR1 IGF-like family receptor 1
IL10RA interleukin 10 receptor, alpha
IL22RA1 interleukin 22 receptor, alpha 1
INHBC inhibin, beta C
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KLHL25 kelch-like family member 25
KRT85 keratin 85, type II
LGALS4 lectin, galactoside-binding, soluble, 4
LMTK2 lemur tyrosine kinase 2
LOC440792 proline dehydrogenase (oxidase) 1 pseudogene
LOC441601 septin 7 pseudogene
LYRM9 LYR motif containing 9
MAGEC1 melanoma antigen family C1
MANSC1 MANSC domain containing 1
MC5R melanocortin 5 receptor
MPPED1 metallophosphoesterase domain containing 1
MTERF4 mitochondrial transcription termination factor 4
MYNN myoneurin
N4BP3 NEDD4 binding protein 3
NCF2 neutrophil cytosolic factor 2
NDN necdin, melanoma antigen (MAGE) family member
NELL2 NEL-like 2 (chicken)
NLK nemo-like kinase
NPTX1 neuronal pentraxin I
NTNG1 netrin G1
NTSR1 neurotensin receptor 1 (high affinity)
NXPH3 neurexophilin 3
OR12D3 olfactory receptor, family 12, subfamily D, member 3
P2RY4 pyrimidinergic receptor P2Y, G-protein coupled, 4
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PALM paralemmin
PENK proenkephalin
PLAC1 placenta-specific 1
PLK2 polo-like kinase 2
PNOC prepronociceptin
PPP1R17 protein phosphatase 1, regulatory subunit 17
PRKCE protein kinase C, epsilon
PTPN7 protein tyrosine phosphatase, non-receptor type 7
RASL10A RAS-like, family 10, member A
RBM4B RNA binding motif protein 4B
RLBP1 retinaldehyde binding protein 1
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SETDB1 SET domain, bifurcated 1
SIGLEC5 sialic acid binding Ig-like lectin 5
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SPP2 secreted phosphoprotein 2, 24kDa
STX5 syntaxin 5
TAS2R14 taste receptor, type 2, member 14
THBS2 thrombospondin 2
THNSL2 threonine synthase-like 2 (S. cerevisiae)
TMPRSS5 transmembrane protease, serine 5
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8
TRIM45 tripartite motif containing 45
TRIM66 tripartite motif containing 66
VSIG4 V-set and immunoglobulin domain containing 4
WDR62 WD repeat domain 62
ZBED2 zinc finger, BED-type containing 2