increased tumor necrosis factor secretion Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium (Mammalian Phenotype Ontology, MP_0008560)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008560
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Genes

83 gene mutations causing the increased tumor necrosis factor secretion phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADORA2B adenosine A2b receptor
ADRB2 adrenoceptor beta 2, surface
AIM2 absent in melanoma 2
AIRE autoimmune regulator
APOE apolipoprotein E
ARRB2 arrestin, beta 2
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
B2M beta-2-microglobulin
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
BPIFA1 BPI fold containing family A, member 1
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCR1 chemokine (C-C motif) receptor 1
CCR2 chemokine (C-C motif) receptor 2
CCR4 chemokine (C-C motif) receptor 4
CD200R1 CD200 receptor 1
CD274 CD274 molecule
CD300A CD300a molecule
CD44 CD44 molecule (Indian blood group)
CLEC4D C-type lectin domain family 4, member D
CLEC6A C-type lectin domain family 6, member A
DMD dystrophin
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP4 dual specificity phosphatase 4
FOS FBJ murine osteosarcoma viral oncogene homolog
FYN FYN proto-oncogene, Src family tyrosine kinase
GFI1 growth factor independent 1 transcription repressor
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GPR34 G protein-coupled receptor 34
GRN granulin
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HSF1 heat shock transcription factor 1
IDO1 indoleamine 2,3-dioxygenase 1
IFNB1 interferon, beta 1, fibroblast
IFNGR1 interferon gamma receptor 1
IRAK3 interleukin-1 receptor-associated kinase 3
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LPAR2 lysophosphatidic acid receptor 2
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MERTK MER proto-oncogene, tyrosine kinase
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
MMP28 matrix metallopeptidase 28
MUC2 mucin 2, oligomeric mucus/gel-forming
NCKAP1L NCK-associated protein 1-like
NCOA3 nuclear receptor coactivator 3
NFIL3 nuclear factor, interleukin 3 regulated
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NLRC3 NLR family, CARD domain containing 3
PBK PDZ binding kinase
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
POMC proopiomelanocortin
PRF1 perforin 1 (pore forming protein)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PYCARD PYD and CARD domain containing
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1
RC3H2 ring finger and CCCH-type domains 2
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SIT1 signaling threshold regulating transmembrane adaptor 1
SOCS2 suppressor of cytokine signaling 2
SOD3 superoxide dismutase 3, extracellular
SSTR4 somatostatin receptor 4
STK17B serine/threonine kinase 17b
STX11 syntaxin 11
SYK spleen tyrosine kinase
TANK TRAF family member-associated NFKB activator
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TBK1 TANK-binding kinase 1
TIMD4 T-cell immunoglobulin and mucin domain containing 4
TIMP3 TIMP metallopeptidase inhibitor 3
TNF tumor necrosis factor
TNFAIP8L2 tumor necrosis factor, alpha-induced protein 8-like 2
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNIP1 TNFAIP3 interacting protein 1
TRAFD1 TRAF-type zinc finger domain containing 1
TREML1 triggering receptor expressed on myeloid cells-like 1
TRIM27 tripartite motif containing 27
TRPV1 transient receptor potential cation channel, subfamily V, member 1
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats
UNC93B1 unc-93 homolog B1 (C. elegans)
ZC3H12A zinc finger CCCH-type containing 12A