increased tumor incidence Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater than the expected number of neoplasms in a specific population in a given time period, usually of a specific type (Mammalian Phenotype Ontology, MP_0002020)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002020
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Genes

390 gene mutations causing the increased tumor incidence phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
A4GNT alpha-1,4-N-acetylglucosaminyltransferase
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4
ACADVL acyl-CoA dehydrogenase, very long chain
ACOX1 acyl-CoA oxidase 1, palmitoyl
ACPP acid phosphatase, prostate
ACTB actin, beta
ACVR1 activin A receptor, type I
AHR aryl hydrocarbon receptor
AIP aryl hydrocarbon receptor interacting protein
AIRE autoimmune regulator
ALOX15 arachidonate 15-lipoxygenase
AMBN ameloblastin (enamel matrix protein)
AMHR2 anti-Mullerian hormone receptor, type II
ANXA7 annexin A7
APC adenomatous polyposis coli
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
AR androgen receptor
ARID4A AT rich interactive domain 4A (RBP1-like)
ASIP agouti signaling protein
ASXL1 additional sex combs like transcriptional regulator 1
ATAD5 ATPase family, AAA domain containing 5
ATG4C autophagy related 4C, cysteine peptidase
ATM ATM serine/threonine kinase
ATP11C ATPase, class VI, type 11C
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
ATR ATR serine/threonine kinase
AURKA aurora kinase A
AURKB aurora kinase B
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
BAD BCL2-associated agonist of cell death
BCL2 B-cell CLL/lymphoma 2
BECN1 beclin 1, autophagy related
BHLHA15 basic helix-loop-helix family, member a15
BHMT betaine--homocysteine S-methyltransferase
BIN3 bridging integrator 3
BLM Bloom syndrome, RecQ helicase-like
BLNK B-cell linker
BMF Bcl2 modifying factor
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BTG3 BTG family, member 3
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
BUB3 BUB3 mitotic checkpoint protein
CABLES1 Cdk5 and Abl enzyme substrate 1
CASC1 cancer susceptibility candidate 1
CAT catalase
CAV1 caveolin 1, caveolae protein, 22kDa
CBX7 chromobox homolog 7
CCNDBP1 cyclin D-type binding-protein 1
CCNG1 cyclin G1
CD226 CD226 molecule
CD34 CD34 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDK11A cyclin-dependent kinase 11A
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDX2 caudal type homeobox 2
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CERS2 ceramide synthase 2
CHD2 chromodomain helicase DNA binding protein 2
CHEK2 checkpoint kinase 2
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CHUK conserved helix-loop-helix ubiquitous kinase
CREBBP CREB binding protein
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSG cathepsin G
CUL9 cullin 9
CXCR3 chemokine (C-X-C motif) receptor 3
CXCR6 chemokine (C-X-C motif) receptor 6
CYGB cytoglobin
CYLD cylindromatosis (turban tumor syndrome)
CYTIP cytohesin 1 interacting protein
DCC DCC netrin 1 receptor
DCLRE1A DNA cross-link repair 1A
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DGKD diacylglycerol kinase, delta 130kDa
DKC1 dyskeratosis congenita 1, dyskerin
DMTF1 cyclin D binding myb-like transcription factor 1
DNA2 DNA replication helicase/nuclease 2
DND1 DND microRNA-mediated repression inhibitor 1
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DOK2 docking protein 2, 56kDa
DOK3 docking protein 3
DPH1 diphthamide biosynthesis 1
DRD2 dopamine receptor D2
E2F1 E2F transcription factor 1
EAF2 ELL associated factor 2
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1
EGR1 early growth response 1
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
EPHA2 EPH receptor A2
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
ERCC2 excision repair cross-complementation group 2
ERCC6 excision repair cross-complementation group 6
ERCC8 excision repair cross-complementation group 8
ERRFI1 ERBB receptor feedback inhibitor 1
ESR2 estrogen receptor 2 (ER beta)
ETV6 ets variant 6
EXO1 exonuclease 1
EXT1 exostosin glycosyltransferase 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FANCD2 Fanconi anemia, complementation group D2
FANCM Fanconi anemia, complementation group M
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FBXO4 F-box protein 4
FEN1 flap structure-specific endonuclease 1
FHIT fragile histidine triad
FLCN folliculin
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FLT3 fms-related tyrosine kinase 3
FOLR1 folate receptor 1 (adult)
FOXM1 forkhead box M1
FOXN1 forkhead box N1
FOXO3 forkhead box O3
FPR2 formyl peptide receptor 2
FSHR follicle stimulating hormone receptor
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GADD45A growth arrest and DNA-damage-inducible, alpha
GAST gastrin
GLIPR1 GLI pathogenesis-related 1
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNMT glycine N-methyltransferase
GON4L gon-4-like (C. elegans)
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPX7 glutathione peroxidase 7
GRM1 glutamate receptor, metabotropic 1
GSTP1 glutathione S-transferase pi 1
GTF2IRD1 GTF2I repeat domain containing 1
H2AFX H2A histone family, member X
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
HCK HCK proto-oncogene, Src family tyrosine kinase
HELQ helicase, POLQ-like
HIC1 hypermethylated in cancer 1
HINT1 histidine triad nucleotide binding protein 1
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HMGA1 high mobility group AT-hook 1
HMGN1 high mobility group nucleosome binding domain 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
HR hair growth associated
HRAS Harvey rat sarcoma viral oncogene homolog
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNAR2 interferon (alpha, beta and omega) receptor 2
IFNG interferon, gamma
IGHM immunoglobulin heavy constant mu
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IKZF3 IKAROS family zinc finger 3 (Aiolos)
IL10 interleukin 10
IL12A interleukin 12A
IL12RB2 interleukin 12 receptor, beta 2
IL22 interleukin 22
IL22RA2 interleukin 22 receptor, alpha 2
IL6ST interleukin 6 signal transducer
ING1 inhibitor of growth family, member 1
ING2 inhibitor of growth family, member 2
INHA inhibin, alpha
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
IP6K2 inositol hexakisphosphate kinase 2
IQGAP2 IQ motif containing GTPase activating protein 2
IRF1 interferon regulatory factor 1
IRF8 interferon regulatory factor 8
JAK2 Janus kinase 2
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KITLG KIT ligand
KLF10 Kruppel-like factor 10
KMT2A lysine (K)-specific methyltransferase 2A
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT14 keratin 14, type I
KRT9 keratin 9, type I
LATS1 large tumor suppressor kinase 1
LIG1 ligase I, DNA, ATP-dependent
LIG4 ligase IV, DNA, ATP-dependent
LMO7 LIM domain 7
LTBP4 latent transforming growth factor beta binding protein 4
LYST lysosomal trafficking regulator
LZTS1 leucine zipper, putative tumor suppressor 1
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAPK8 mitogen-activated protein kinase 8
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MC4R melanocortin 4 receptor
MCM2 minichromosome maintenance complex component 2
MCM4 minichromosome maintenance complex component 4
MCM8 minichromosome maintenance complex component 8
MCM9 minichromosome maintenance complex component 9
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEN1 multiple endocrine neoplasia I
MET MET proto-oncogene, receptor tyrosine kinase
MGMT O-6-methylguanine-DNA methyltransferase
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MIR122 microRNA 122
MLH1 mutL homolog 1
MMP7 matrix metallopeptidase 7
MMP8 matrix metallopeptidase 8
MOS v-mos Moloney murine sarcoma viral oncogene homolog
MSH2 mutS homolog 2
MSH3 mutS homolog 3
MSH6 mutS homolog 6
MSMB microseminoprotein, beta-
MTF1 metal-regulatory transcription factor 1
MTSS1 metastasis suppressor 1
MTUS1 microtubule associated tumor suppressor 1
MUC2 mucin 2, oligomeric mucus/gel-forming
MUS81 MUS81 structure-specific endonuclease subunit
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH14 myosin, heavy chain 14, non-muscle
MZF1 myeloid zinc finger 1
NBN nibrin
NCOA3 nuclear receptor coactivator 3
NCOA5 nuclear receptor coactivator 5
NDRG1 N-myc downstream regulated 1
NEIL1 nei endonuclease VIII-like 1 (E. coli)
NF1 neurofibromin 1
NF2 neurofibromin 2 (merlin)
NFE2 nuclear factor, erythroid 2
NFE2L2 nuclear factor, erythroid 2-like 2
NIT1 nitrilase 1
NKX2-8 NK2 homeobox 8
NKX3-1 NK3 homeobox 1
NLRP12 NLR family, pyrin domain containing 12
NLRP6 NLR family, pyrin domain containing 6
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOTCH1 notch 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
NR0B1 nuclear receptor subfamily 0, group B, member 1
NR1H4 nuclear receptor subfamily 1, group H, member 4
NUAK2 NUAK family, SNF1-like kinase, 2
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
OGG1 8-oxoguanine DNA glycosylase
PAQR3 progestin and adipoQ receptor family member III
PAX6 paired box 6
PCSK6 proprotein convertase subtilisin/kexin type 6
PCYT1B phosphate cytidylyltransferase 1, choline, beta
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PER2 period circadian clock 2
PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1
PKD1 polycystic kidney disease 1 (autosomal dominant)
PLCD1 phospholipase C, delta 1
PLCL1 phospholipase C-like 1
PLK1 polo-like kinase 1
PLK3 polo-like kinase 3
PML promyelocytic leukemia
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POLE polymerase (DNA directed), epsilon, catalytic subunit
POLG polymerase (DNA directed), gamma
POLH polymerase (DNA directed), eta
POMC proopiomelanocortin
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PRDM2 PR domain containing 2, with ZNF domain
PRDX1 peroxiredoxin 1
PRF1 perforin 1 (pore forming protein)
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRKCA protein kinase C, alpha
PRKCH protein kinase C, eta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRL prolactin
PRLR prolactin receptor
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTCH1 patched 1
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRJ protein tyrosine phosphatase, receptor type, J
PTPRT protein tyrosine phosphatase, receptor type, T
RAD50 RAD50 homolog (S. cerevisiae)
RAE1 ribonucleic acid export 1
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic)
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RASSF5 Ras association (RalGDS/AF-6) domain family member 5
RB1 retinoblastoma 1
RBBP8 retinoblastoma binding protein 8
RC3H1 ring finger and CCCH-type domains 1
RECQL4 RecQ protein-like 4
RET ret proto-oncogene
RFWD2 ring finger and WD repeat domain 2, E3 ubiquitin protein ligase
RGPD1 RANBP2-like and GRIP domain containing 1
RHOB ras homolog family member B
RINT1 RAD50 interactor 1
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPA1 replication protein A1, 70kDa
RUNX1 runt-related transcription factor 1
S100A4 S100 calcium binding protein A4
SAMD9L sterile alpha motif domain containing 9-like
SAV1 salvador family WW domain containing protein 1
SCRIB scribbled planar cell polarity protein
SF1 splicing factor 1
SFN stratifin
SGOL1 shugoshin-like 1 (S. pombe)
SIPA1 signal-induced proliferation-associated 1
SIRT2 sirtuin 2
SKI SKI proto-oncogene
SKIL SKI-like proto-oncogene
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SMAD9 SMAD family member 9
SMAP1 small ArfGAP 1
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SOAT1 sterol O-acyltransferase 1
SOCS1 suppressor of cytokine signaling 1
SOD2 superoxide dismutase 2, mitochondrial
SPG20 spastic paraplegia 20 (Troyer syndrome)
SPI1 Spi-1 proto-oncogene
SPRY2 sprouty homolog 2 (Drosophila)
SPTBN1 spectrin, beta, non-erythrocytic 1
SRPX sushi-repeat containing protein, X-linked
SSBP2 single-stranded DNA binding protein 2
STAG1 stromal antigen 1
STK11 serine/threonine kinase 11
STK3 serine/threonine kinase 3
STK4 serine/threonine kinase 4
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
TCF3 transcription factor 3
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TERC telomerase RNA component
TES testin LIM domain protein
TET2 tet methylcytosine dioxygenase 2
TFF1 trefoil factor 1
TGFB1 transforming growth factor, beta 1
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS2 thrombospondin 2
THRB thyroid hormone receptor, beta
TIAM1 T-cell lymphoma invasion and metastasis 1
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TMPRSS11D transmembrane protease, serine 11D
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNK1 tyrosine kinase, non-receptor, 1
TOM1L2 target of myb1-like 2 (chicken)
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
TP53BP2 tumor protein p53 binding protein 2
TP53INP1 tumor protein p53 inducible nuclear protein 1
TP63 tumor protein p63
TP73 tumor protein p73
TPX2 TPX2, microtubule-associated
TREX2 three prime repair exonuclease 2
TRIM24 tripartite motif containing 24
TRIM62 tripartite motif containing 62
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TSC1 tuberous sclerosis 1
TSC2 tuberous sclerosis 2
TSPAN33 tetraspanin 33
TTC7A tetratricopeptide repeat domain 7A
TUSC2 tumor suppressor candidate 2
TXNIP thioredoxin interacting protein
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats
UIMC1 ubiquitin interaction motif containing 1
UNG uracil-DNA glycosylase
USP44 ubiquitin specific peptidase 44
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
WIF1 WNT inhibitory factor 1
WRN Werner syndrome, RecQ helicase-like
WWOX WW domain containing oxidoreductase
XPA xeroderma pigmentosum, complementation group A
XPC xeroderma pigmentosum, complementation group C
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZEB1 zinc finger E-box binding homeobox 1
ZFHX3 zinc finger homeobox 3