increased trophoblast giant cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater than normal number of cells of the extraembryonic cell layer that contributes to the placenta (Mammalian Phenotype Ontology, MP_0009397)
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13 gene mutations causing the increased trophoblast giant cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
BMP5 bone morphogenetic protein 5
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like
FGFR2 fibroblast growth factor receptor 2
IL11RA interleukin 11 receptor, alpha
ITGB7 integrin, beta 7
KDM6A lysine (K)-specific demethylase 6A
NCOA6 nuclear receptor coactivator 6
NODAL nodal growth differentiation factor
PLAC1 placenta-specific 1
SOCS3 suppressor of cytokine signaling 3
SOX2 SRY (sex determining region Y)-box 2
TXNRD1 thioredoxin reductase 1
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae)