increased thymus tumor incidence Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater than the expected number of neoplams in the thymus occurring in a specific population in a given time period (Mammalian Phenotype Ontology, MP_0010365)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0010365
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Genes

50 gene mutations causing the increased thymus tumor incidence phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ATAD5 ATPase family, AAA domain containing 5
ATM ATM serine/threonine kinase
BMF Bcl2 modifying factor
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CHD2 chromodomain helicase DNA binding protein 2
E2F1 E2F transcription factor 1
EGR1 early growth response 1
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
H2AFX H2A histone family, member X
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IFNG interferon, gamma
IKZF1 IKAROS family zinc finger 1 (Ikaros)
KRAS Kirsten rat sarcoma viral oncogene homolog
LIG4 ligase IV, DNA, ATP-dependent
MCM2 minichromosome maintenance complex component 2
MCM4 minichromosome maintenance complex component 4
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MGMT O-6-methylguanine-DNA methyltransferase
MLH1 mutL homolog 1
MSH2 mutS homolog 2
MTF1 metal-regulatory transcription factor 1
NBN nibrin
NDRG1 N-myc downstream regulated 1
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
PRDX1 peroxiredoxin 1
PRF1 perforin 1 (pore forming protein)
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTEN phosphatase and tensin homolog
RAD50 RAD50 homolog (S. cerevisiae)
RC3H1 ring finger and CCCH-type domains 1
RFWD2 ring finger and WD repeat domain 2, E3 ubiquitin protein ligase
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
RUNX1 runt-related transcription factor 1
SKIL SKI-like proto-oncogene
SPI1 Spi-1 proto-oncogene
SRPX sushi-repeat containing protein, X-linked
TCF3 transcription factor 3
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
TP53BP2 tumor protein p53 binding protein 2
TP73 tumor protein p73
UIMC1 ubiquitin interaction motif containing 1
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZEB1 zinc finger E-box binding homeobox 1