increased t follicular helper cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater number of the CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cells located in follicles of secondary lymph nodes that expresses high levels of BCL-6, ICOS and PD1 and stimulate follicular B cells to undergo class-switching and antibody production (Mammalian Phenotype Ontology, MP_0010186)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0010186
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Genes

5 gene mutations causing the increased t follicular helper cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
PNP purine nucleoside phosphorylase
RC3H1 ring finger and CCCH-type domains 1
SCARF1 scavenger receptor class F, member 1
TNIP1 TNFAIP3 interacting protein 1