increased t cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater than normal T cell numbers (Mammalian Phenotype Ontology, MP_0005015)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005015
Similar Terms
Downloads & Tools

Genes

304 gene mutations causing the increased t cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACE angiotensin I converting enzyme
ACKR4 atypical chemokine receptor 4
ACSL3 acyl-CoA synthetase long-chain family member 3
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ADGRB1 adhesion G protein-coupled receptor B1
ADRM1 adhesion regulating molecule 1
AIRE autoimmune regulator
AKAP9 A kinase (PRKA) anchor protein 9
ANPEP alanyl (membrane) aminopeptidase
APOE apolipoprotein E
ARID4A AT rich interactive domain 4A (RBP1-like)
ARID5A AT rich interactive domain 5A (MRF1-like)
ARID5B AT rich interactive domain 5B (MRF1-like)
ARL4D ADP-ribosylation factor-like 4D
ASXL1 additional sex combs like transcriptional regulator 1
ATM ATM serine/threonine kinase
B2M beta-2-microglobulin
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BAX BCL2-associated X protein
BBC3 BCL2 binding component 3
BCL10 B-cell CLL/lymphoma 10
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCL2 B-cell CLL/lymphoma 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BHLHE40 basic helix-loop-helix family, member e40
BIRC3 baculoviral IAP repeat containing 3
BLNK B-cell linker
BMF Bcl2 modifying factor
BTK Bruton agammaglobulinemia tyrosine kinase
C10ORF11 chromosome 10 open reading frame 11
C17ORF62 chromosome 17 open reading frame 62
CADM1 cell adhesion molecule 1
CARD11 caspase recruitment domain family, member 11
CBFB core-binding factor, beta subunit
CCL13 chemokine (C-C motif) ligand 13
CCNB2 cyclin B2
CCND3 cyclin D3
CCR2 chemokine (C-C motif) receptor 2
CCR4 chemokine (C-C motif) receptor 4
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR6 chemokine (C-C motif) receptor 6
CCR7 chemokine (C-C motif) receptor 7
CCR9 chemokine (C-C motif) receptor 9
CD19 CD19 molecule
CD247 CD247 molecule
CD274 CD274 molecule
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD4 CD4 molecule
CD40LG CD40 ligand
CD48 CD48 molecule
CD5 CD5 molecule
CD7 CD7 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD8A CD8a molecule
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CDK6 cyclin-dependent kinase 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
CENPJ centromere protein J
CHD2 chromodomain helicase DNA binding protein 2
CHD7 chromodomain helicase DNA binding protein 7
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CIITA class II, major histocompatibility complex, transactivator
CLEC4G C-type lectin domain family 4, member G
COL10A1 collagen, type X, alpha 1
CORO1A coronin, actin binding protein, 1A
CRTAM cytotoxic and regulatory T cell molecule
CSF1 colony stimulating factor 1 (macrophage)
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTSE cathepsin E
CTSV cathepsin V
CXCR2 chemokine (C-X-C motif) receptor 2
CYLD cylindromatosis (turban tumor syndrome)
DCK deoxycytidine kinase
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DGKA diacylglycerol kinase, alpha 80kDa
DGKZ diacylglycerol kinase, zeta
DIAPH1 diaphanous-related formin 1
DLL1 delta-like 1 (Drosophila)
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DUSP10 dual specificity phosphatase 10
DUSP4 dual specificity phosphatase 4
E2F1 E2F transcription factor 1
E2F2 E2F transcription factor 2
E2F4 E2F transcription factor 4, p107/p130-binding
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
ESR1 estrogen receptor 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FAM83G family with sequence similarity 83, member G
FARSA phenylalanyl-tRNA synthetase, alpha subunit
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FBXO7 F-box protein 7
FCMR Fc fragment of IgM receptor
FFAR2 free fatty acid receptor 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXN1 forkhead box N1
FOXP2 forkhead box P2
FOXP3 forkhead box P3
GADD45A growth arrest and DNA-damage-inducible, alpha
GALR2 galanin receptor 2
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GPR15 G protein-coupled receptor 15
GRAP GRB2-related adaptor protein
GRAP2 GRB2-related adaptor protein 2
HAVCR1 hepatitis A virus cellular receptor 1
HELLS helicase, lymphoid-specific
HLA-A major histocompatibility complex, class I, A
HLA-DOA major histocompatibility complex, class II, DO alpha
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGN5 high mobility group nucleosome binding domain 5
HP1BP3 heterochromatin protein 1, binding protein 3
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFNG interferon, gamma
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL10 interleukin 10
IL13RA1 interleukin 13 receptor, alpha 1
IL15RA interleukin 15 receptor, alpha
IL17A interleukin 17A
IL17F interleukin 17F
IL17RA interleukin 17 receptor A
IL2 interleukin 2
IL20RB interleukin 20 receptor beta
IL25 interleukin 25
IL2RA interleukin 2 receptor, alpha
IL2RB interleukin 2 receptor, beta
IL6ST interleukin 6 signal transducer
IL7R interleukin 7 receptor
IL9R interleukin 9 receptor
IRF1 interferon regulatory factor 1
IRF2 interferon regulatory factor 2
ITGAD integrin, alpha D
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITK IL2-inducible T-cell kinase
ITPKB inositol-trisphosphate 3-kinase B
JAK1 Janus kinase 1
JAK3 Janus kinase 3
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12
KLF13 Kruppel-like factor 13
KRAS Kirsten rat sarcoma viral oncogene homolog
LAG3 lymphocyte-activation gene 3
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LAT linker for activation of T cells
LAT2 linker for activation of T cells family, member 2
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LECT2 leukocyte cell-derived chemotaxin 2
LGALS9B lectin, galactoside-binding, soluble, 9B
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
LYN LYN proto-oncogene, Src family tyrosine kinase
MAML1 mastermind-like 1 (Drosophila)
MAN2A1 mannosidase, alpha, class 2A, member 1
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5
MAPK14 mitogen-activated protein kinase 14
MIR155 microRNA 155
MIR181D microRNA 181d
MMP19 matrix metallopeptidase 19
MMP9 matrix metallopeptidase 9
MPG N-methylpurine-DNA glycosylase
MPZL2 myelin protein zero-like 2
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYSM1 Myb-like, SWIRM and MPN domains 1
NCKAP1L NCK-associated protein 1-like
NCOA3 nuclear receptor coactivator 3
NDFIP1 Nedd4 family interacting protein 1
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFIL3 nuclear factor, interleukin 3 regulated
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NLRP3 NLR family, pyrin domain containing 3
NOD2 nucleotide-binding oligomerization domain containing 2
NOS2 nitric oxide synthase 2, inducible
NPY1R neuropeptide Y receptor Y1
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1
PAX1 paired box 1
PAX5 paired box 5
PDCD1 programmed cell death 1
PDCD1LG2 programmed cell death 1 ligand 2
PEX3 peroxisomal biogenesis factor 3
PI16 peptidase inhibitor 16
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PITX3 paired-like homeodomain 3
PKNOX1 PBX/knotted 1 homeobox 1
PLA2G2D phospholipase A2, group IID
PNP purine nucleoside phosphorylase
POLB polymerase (DNA directed), beta
PPIA peptidylprolyl isomerase A (cyclophilin A)
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP5C protein phosphatase 5, catalytic subunit
PRF1 perforin 1 (pore forming protein)
PRKCH protein kinase C, eta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRMT3 protein arginine methyltransferase 3
PTCRA pre T-cell antigen receptor alpha
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPRC protein tyrosine phosphatase, receptor type, C
PTTG1 pituitary tumor-transforming 1
RAG1 recombination activating gene 1
RAG2 recombination activating gene 2
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RASSF5 Ras association (RalGDS/AF-6) domain family member 5
RC3H1 ring finger and CCCH-type domains 1
REG3G regenerating islet-derived 3 gamma
RGS3 regulator of G-protein signaling 3
RHOH ras homolog family member H
RNASE10 ribonuclease, RNase A family, 10 (non-active)
RNF168 ring finger protein 168, E3 ubiquitin protein ligase
RORC RAR-related orphan receptor C
RRAS related RAS viral (r-ras) oncogene homolog
RUNX1 runt-related transcription factor 1
RUVBL2 RuvB-like AAA ATPase 2
S1PR1 sphingosine-1-phosphate receptor 1
S1PR2 sphingosine-1-phosphate receptor 2
SCARF1 scavenger receptor class F, member 1
SETD1A SET domain containing 1A
SETD5 SET domain containing 5
SETDB1 SET domain, bifurcated 1
SGMS1 sphingomyelin synthase 1
SGPL1 sphingosine-1-phosphate lyase 1
SH2D1A SH2 domain containing 1A
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin
SIRT2 sirtuin 2
SIT1 signaling threshold regulating transmembrane adaptor 1
SLC39A3 solute carrier family 39 (zinc transporter), member 3
SMC3 structural maintenance of chromosomes 3
SMS spermine synthase
SOCS1 suppressor of cytokine signaling 1
SPI1 Spi-1 proto-oncogene
SPNS2 spinster homolog 2 (Drosophila)
SPTA1 spectrin, alpha, erythrocytic 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STK17B serine/threonine kinase 17b
STK4 serine/threonine kinase 4
SYK spleen tyrosine kinase
SYTL1 synaptotagmin-like 1
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TBATA thymus, brain and testes associated
TBK1 TANK-binding kinase 1
TBX21 T-box 21
TCF12 transcription factor 12
TCF3 transcription factor 3
TCF4 transcription factor 4
TESPA1 thymocyte expressed, positive selection associated 1
TET2 tet methylcytosine dioxygenase 2
TGFB1 transforming growth factor, beta 1
THBS1 thrombospondin 1
THEMIS thymocyte selection associated
TIMMDC1 translocase of inner mitochondrial membrane domain containing 1
TLR2 toll-like receptor 2
TMEM127 transmembrane protein 127
TMEM98 transmembrane protein 98
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP8L2 tumor necrosis factor, alpha-induced protein 8-like 2
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TNIP1 TNFAIP3 interacting protein 1
TOM1L2 target of myb1-like 2 (chicken)
TP53BP1 tumor protein p53 binding protein 1
TPP2 tripeptidyl peptidase II
TRIB2 tribbles pseudokinase 2
TWSG1 twisted gastrulation BMP signaling modulator 1
TXNIP thioredoxin interacting protein
UBE2B ubiquitin-conjugating enzyme E2B
UNC13D unc-13 homolog D (C. elegans)
UNC93B1 unc-93 homolog B1 (C. elegans)
USP42 ubiquitin specific peptidase 42
VAV1 vav 1 guanine nucleotide exchange factor
VCAM1 vascular cell adhesion molecule 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WDR37 WD repeat domain 37
WDTC1 WD and tetratricopeptide repeats 1
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZBTB7B zinc finger and BTB domain containing 7B
ZC3H12A zinc finger CCCH-type containing 12A
ZC3H12D zinc finger CCCH-type containing 12D
ZEB1 zinc finger E-box binding homeobox 1
ZNF175 zinc finger protein 175
ZP1 zona pellucida glycoprotein 1 (sperm receptor)